Pediatric Neurology
Volume 12, Issue 2 , Pages 139-145 , February 1995

Thyrotropin-releasing hormone in treatment of intractable epilepsy: Neurochemical analysis of CSF monoamine metabolites

  • Yoshihiro Takeuchi, MD

      Affiliations

    • Corresponding Author InformationCommunication should be addressed to: Dr. Takeuchi; Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku; Kyoto 602, Japan.
    • Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan
    • ,
  • Masashi Tominaga, MD

      Affiliations

    • Department of Pediatrics, Kyoto Municipal Hospital, Japan
    • ,
  • Nobuto Mitsufuji, MD

      Affiliations

    • Department of Pediatrics, Kyoto First Red Cross Hospital, Kyoto, Japan
    • ,
  • Ichiro Yamazoe, MD

      Affiliations

    • Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan
    • ,
  • Syouji Kawase, MD

      Affiliations

    • Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan
    • ,
  • Akira Nishimura, MD

      Affiliations

    • Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan
    • ,
  • Satoshi Matsuo, MD

      Affiliations

    • Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan
    • ,
  • Tadashi Sawada, MD

      Affiliations

    • Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan

Received 19 September 1994 ,Accepted 12 December 1994.

References 

  1. Matsuishi T, Yano E, Inagawa K, et al.  A pilot study on the anticonvulsive effects of a thyrotropin-releasing hormone analog in intractable epilepsy. Brain Dev. 1983;5:421–428
  2. Matsumoto A, Kumagai T, Takeuchi T, Miyazaki S, Watanabe K. Clinical effects of thyrotropin-releasing hormone for severe epilepsy in childhood: A comparative study with ACTH therapy. Epilepsia. 1987;28:49–55
  3. Matsumoto A, Kumagai T, Takeuchi T, Miyazaki S, Watanabe K. Factors influencing the effectiveness of thyrotropin-releasing hormone therapy for severe epilepsy in childhood: Significance of serum prolactin levels. Epilepsia. 1989;30:45–49
  4. Takeuchi Y, Fujiwara K, Ishimura K, et al.  Efficacy of thyrotropin-releasing hormone in the treatment of cerebellar ataxia. Pediatr Neurol. 1989;5:107–110
  5. Takeuchi Y, Miyanomae Y, Komatsu H, et al.  Efficacy of thyrotropin-releasing hormone in the treatment of spinal muscular atrophy. J Child Neurol. 1994;9:287–289
  6. Agarwal RA, Rastogi RB, Singhal RL. Enhancement of locomotor activity and catecholamine and 5-hydroxytryptamine metabolism by thyrotropin-releasing hormone. Neuroendocrinology. 1977;23:236–247
  7. Kerwin RW, Pycock CJ. Thyrotropin-releasing hormone stimulates release of [3H]dopamine from slices of rat nucleus accumbens in vitro. Br J Pharmacol. 1979;67:323–325
  8. Kubek MJ, Knoblach SM, Sharif NA, Burt DR, Buterbaugh GG, Fuson KS. Thyrotropin-releasing hormone gene expression and receptors are differentially modified in limbic foci by seizures. Ann Neurol. 1993;33:70–76
  9. Morimoto K, Goddard GV. Effects of thyrotropin-releasing hormone on evoked responses and long-term potentiation in the dentate gyrus of rat. Exp Neurol. 1985;90:401–410
  10. Rastogi RB, Singhal RL, Lapierre YD. Effects of MK-771, a novel TRH analogue, on brain dopaminergic and serotonergic systems. Eur J Pharmacol. 1981;73:307–312
  11. Sato M, Morimoto K, Wada JA. Antiepileptic effects of thyrotropin-releasing hormone and its new derivatives, DN-1417, examined in feline amygdaloid kindling preparation. Epilepsia. 1984;25:537–544
  12. Sharp T, Bennett GW, Marsden CA. Thyrotropin-releasing hormone analogues increase dopamine release from slices of rat brain. J Neurochem. 1982;39:1763–1766
  13. Yamashita K, Mori A, Otsuki S. Changes in brain thyrotropin-releasing hormone (TRH) of seizure-prone E1 mice. Exp Neurol. 1990;108:71–75
  14. Matson WR, Langlais PJ, Volicer L, Gamache PH, Bird E, Mark KA. n-Electrode three-dimensional liquid chromatography with electrochemical detection for the determination of neurotransmitters. Clin Chem. 1984;30:1158–1161
  15. Takeuchi Y, Komatsu H, Matsuo S, et al.  Monoamine metabolites in the cerebrospinal fluid in infantile spinal muscular atrophy. Neuroreport. 1994;5:898–900

☆ This study was supported in part by grants from the Mother and Child Health Foundation, and the Ministry of Education, Science and Culture, Japan.

PII: 0887-8994(94)00149-V

Pediatric Neurology
Volume 12, Issue 2 , Pages 139-145 , February 1995

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