Pediatric Neurology
Volume 25, Issue 1 , Pages 63-66 , July 2001

Congenital insensitivity to pain with anhidrosis

  • László Sztriha, MD, PhD

      Affiliations

    • Department of Pediatrics; Faculty of Medicine and Health Sciences; United Arab Emirates University; Al Ain, United Arab Emirates
    • Corresponding Author InformationCommunications should be addressed to: Dr. Sztriha; Department of Pediatrics; FMHS; UAE University; P.O.Box: 17666; Al Ain, United Arab Emirates
    • ,
  • Gilles G Lestringant, MD

      Affiliations

    • Department of Internal Medicine; Tawam Hospital; Al Ain, United Arab Emirates
    • ,
  • Jozef Hertecant, MD

      Affiliations

    • Department of Pediatrics; Tawam Hospital; Al Ain, United Arab Emirates
    • ,
  • Philippe M Frossard, MD

      Affiliations

    • Department of Pathology; Faculty of Medicine and Health Sciences; United Arab Emirates University; Al Ain, United Arab Emirates
    • ,
  • Isabelle Masouyé, MD

      Affiliations

    • Department of Dermatology; Hopital Cantonal Universitaire; Geneva, Switzerland

Received 27 November 2000 ,Accepted 28 February 2001.

References 

  1. Ismail EAR, Al-Shammari N, Anim JT, Moosa A. Congenital insensitivity to pain with anhidrosis (Lack of eccrine sweat gland innervation confirmed). J Child Neurol. 1998;13:243–246
  2. Itoh Y, Yagishita S, Nakajima S, Nakano T. Congenital insensitivity to pain with anhidrosis (Morphological and morphometrical studies on the skin and peripheral nerves). Neuropediatrics. 1986;17:103–110
  3. Rosemberg S, Marie SKN, Kliemann S. Congenital insensitivity to pain with anhidrosis (hereditary sensory and autonomic neuropathy type IV). Pediatr Neurol. 1994;11:50–56
  4. Toscano E, della Casa R, Mardy S, et al.  Multisystem involvement in congenital insensitivity to pain with anhidrosis (CIPA), a nerve growth factor receptor (Trk A)-related disorder. Neuropediatrics. 2000;31:39–41
  5. Swanson AG, Buchan GC, Alvord EC. Anatomic changes in congenital insensitivity to pain. Arch Neurol. 1965;12:12–18
  6. Snider WD. Functions of the neurotrophins during nervous system development (What the knockouts are teaching us). Cell. 1994;77:627–638
  7. Mardy S, Miura Y, Endo F, et al.  Congenital insensitivity to pain with anhidrosis (Novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor). Am J Hum Genet. 1999;64:1570–1579
  8. Langer J, Goebel HH, Veit S. Eccrine sweat glands are not innervated in hereditary sensory neuropathy type IV. Acta Neuropathol. 1981;54:199–202
  9. Kahn HJ, Baumal R, Marks A. The value of immunohistochemical studies using antibody to S100 protein in dermatopathology. Int J Dermatol. 1984;23:38–44
  10. Martin-Zanca D, Barbacid M, Parada LF. Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes Dev. 1990;4:683–694
  11. Miozzo M, Pierotti MA, Sozzi G, et al.  Human TRK proto-oncogene maps to chromosome 1q32-q41. Oncogene. 1990;5:1411–1414
  12. Indo Y, Mardy S, Tsuruta M, Karim MA, Matsuda I. Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor. Jpn J Hum Genet. 1997;42:343–351
  13. Greco A, Villa R, Fusetti L, Orlandi R, Pierotti MA. The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor. J Cell Physiol. 2000;182:127–133
  14. Levi-Montalcini R, Skaper SD, Toso RD, Petrelli L, Leon A. Nerve growth factor (from neurotrophin to neurokine). Trends Neurosci. 1996;19:514–520
  15. Grills BL, Schuijers JA. Immunohistochemical localization of nerve growth factor in fractured and unfractured rat bone. Acta Orthop Scand. 1998;69:415–419

PII: S0887-8994(01)00278-8

Pediatric Neurology
Volume 25, Issue 1 , Pages 63-66 , July 2001

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