Pediatric Neurology
Volume 25, Issue 1 , Pages 43-46 , July 2001

Thyroid hormones in epileptic children receiving carbamazepine and valproic acid

  • Alberto Verrotti, MD, PhD

      Affiliations

    • Department of Medicine; Section of Pediatrics; University of Chieti; Chieti, Italy
    • Corresponding Author InformationCommunications should be addressed to: Dr. Verrotti; Department of Medicine; Section of Pediatrics; University of Chieti-Ospedale Policlinico; Via dei Vestini 5; 66100 Chieti, Italy
    • ,
  • Fania Basciani, RD

      Affiliations

    • Department of Medicine; Section of Pediatrics; University of Chieti; Chieti, Italy
    • ,
  • Simonetta Morresi, MD

      Affiliations

    • Department of Medicine; Section of Pediatrics; University of Chieti; Chieti, Italy
    • ,
  • Guido Morgese, MD

      Affiliations

    • Department of Pediatrics; University of Siena; Siena, Italy
    • ,
  • Francesco Chiarelli, MD

      Affiliations

    • Department of Medicine; Section of Pediatrics; University of Chieti; Chieti, Italy

Received 6 December 2000 ,Accepted 5 March 2001.

References 

  1. Dodson WE. Medical treatment and pharmacology of antiepileptic drugs. In:  Pellock JM editors. The pediatric clinics of North America. Seizure disorders. Philadelphia: WB Saunders; 1989;p. 421–433
  2. Eadie MJ, Tyrer JH. Carbamazepine. In: Anticonvulsant therapy-pharmacological basis and practice, 3rd ed. Oxford: Churchill Livingstone, 1989:142–54.
  3. Pellock JM. Efficacy and adverse effects of antiepileptic drugs. In:  Pellock JM editors. The pediatric clinics of North America. Seizure disorders. Philadelphia: WB Saunders Company; 1989;p. 435–448
  4. de Silva M, McArdle B, McGowan M. Randomized comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed chilhood epilepsy. Lancet. 1996;347:709–713
  5. Heller AJ, Chestermen P, Elwes RDC. Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy (A randomized comparative monotherapy trial). J Neurol Neurosurg Psychiatry. 1995;58:44–50
  6. Isojarvi JIT, Pakarinen AJ, Yipalosaari PJ, MyllyIä VV. Serum hormones in male epileptic patients receiving anticonvulsant medication. Arch Neurol. 1990;47:670–676
  7. Murialdo G, Galimberti CA, Fonzi S, Manni R, Costelli P, Parodi C. Sex hormones, gonadotropins, and prolactin in male epileptic subjects in remission. Role of the epileptic syndrome and of antiepileptic treatment. Neuropsychobiology. 1994;30:29–36
  8. Toone BK, Edeh J, Fenwick P. Hormonal and behavioral changes in male epileptics. In:  Porter RJ,  Ward AA,  Mattson RH,  Dam M editor. Advances in epileptology. XVth Epilepsy International Symposium. New York: Raven Press; 1984;p. 283–289
  9. Toone BK, Wheeler M, Fenwick P. Sex hormone changes in male epileptics. Clin Endocrinol. 1980;12:391–395
  10. Isojärvi JI, Laatikainen TJ, Knip M, Pakarinen AJ, Juntunen KT, MyllyIä VV. Obesity and endocrine disorders in women taking valproate for epilepsy. Ann Neurol. 1996;39:579–584
  11. Fichsel H, Knöpfie G. Effects of anticonvulsant drugs on thyroid hormones in epileptic children. Epilepsia. 1978;19:323–336
  12. Liewendahl K, Majuri H, Helenius T. Thyroid function tests in patients on long-term treatment with variuos anriconvulsant drugs. Clin Endocrinol. 1978;8:185–191
  13. Haidukewych D, Rodin EA. Chronic antiepileptic drug therapy (Classification by medication regimen and incidence of decreases in serum thyroxine and free thyroxine index). Ther Drug Monit. 1987;9:392–398
  14. Liihdorf K, Christiansen P, Hansen JM, Lund M. The influence of phenytoin and carbarnazepine on endocrine function: Preliminary results. In:  Penry JK editors. Pediatric endocrinology. New York: Raven Press; 1977;p. 209–213
  15. Isojärvi JIT, Pakarinen AJ, MyllyIä VV. Thyroid function in epileptic patients treated with carbarnazepine. Arch Neurol. 1989;46:1175–1178
  16. Yeo PP, Bates D, Howe JG, et al.  Anticonvulsants and thyroid function. Br Med J. 1978;1:1581–1583
  17. Rootwelt K, Ganes T, Johannesen SI. Effect of carbamazepine, phenytoin and phenobarbital on serum levels of thyroid hormones and thyrotropin in humans. Scand Clin Lab Invest. 1978;38:731–736
  18. Bentsen KD, Gram L, Veje A. Serum thyroid hormones and blood folic acid during monotherapy with carbarnazepine or valproate. Acta Neurol Scand. 1983;67:235–241
  19. Connell JMC, Rapeport WG, Gordon S, Brodie MJ. Changes in circulating thyroid hormones during short-term hepatic enzyme induction with carbarnazepine. Eur J Clin Pharmacol. 1984;26:453–456
  20. Tanaka K, Kodama S, Yokoyama S, et al.  Thyroid function in children with long-term anticonvulsant treatment. Pediatr Neurosci. 1987;13:90–94
  21. Larkin JG, MacPhee GJA, Beastall GH, Brodie MJ. Thyroid hormone concentrations in epileptic patients. Eur J Clin Pharmacol. 1989;36:213–216
  22. De Luca F, Arrigo T, Pandullo E, Siracusano MF, Benvenga S, Trimarchi F. Changes in thyroid function tests induced by 2 months carbamazepine treatment in L-thyroxine-substituted hypothyroid children. Eur J Pediatr. 1986;145:77–79
  23. Roy-Byrne PP, Joffe RT, Uhde TW, Post RM. Carbamazepine and thyroid function in affectively ill patiets. Arch Gen Psychiatry. 1984;41:1150–1153
  24. Perucca E, Hedges A, Makki KA, Ruprah M, Wilson JF, Richens A. A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. Br J Clin Pharmacol. 1984;18:401–410
  25. Aanderud S, Myking OL, Strandjord RE. The influence of carbarnazepine on thyroid hormones and thyroxine binding globulin in hypothyroid patients substituted with thyroxine. Clin Endocrinol. 1981;15:247–252
  26. Kaplan MM. Subcellular alterations causing reduced hepatic thyroxine 5′ monodeiodinase activity in fasted rats. Endocrinology. 1979;104:58–64
  27. Eravci M, Pinna G, Meinhold H, Baumgartner A. Effects of pharmacological and nonpharmacological treatments on thyroid hormone metabolism and concentrations in rat brain. Endocrinology. 2000;141:1027–1040
  28. Blank DW, Joffe RT. Effect of carbamazepine on thyroid hormone measurement in vitro. Clin Chim Acta. 1984;143:173–176
  29. Dana-Haeri J, Oxley J, Richens A. Pituitary responsiveness to gonadotrophin-releasing and thyrotrophin-releasing hormones in epileptic patients receiving carbarnazepine or phenytoin. Clin Endocrinol. 1984;20:163–176
  30. Joffe RT, Gold PW, Uhde TW, Post RM. The effects of carbamazepine on the thyrotropin response to thyrotropin-releasing hormone. Psychiatry Res. 1984;12:161–166
  31. Eiris-Punal J, Del Rio-Garma M, Del Rio-Garma MC, Lojo-Rocamode S, Novo-Rodriguez I, Castro-Gago M. Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. Epilepsia. 1999;40:1761–1766

PII: S0887-8994(01)00279-X

Pediatric Neurology
Volume 25, Issue 1 , Pages 43-46 , July 2001

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