Pediatric Neurology
Volume 25, Issue 1 , Pages 59-61, July 2001

Late-Onset GM2 gangliosidosis presenting as burning dysesthesias

  • Gabriel C.S Chow, MB

      Affiliations

    • Division of Neurology; University of Toronto and The Hospital for Sick Children; Toronto, Ontario, Canada
    • ,
  • Joe T.R Clarke, MD, PhD

      Affiliations

    • Department of Paediatrics; University of Toronto and Division of Clinical Medical Genetics; The Hospital for Sick Children; Toronto, Ontario, Canada
    • ,
  • Brenda L Banwell, MD

      Affiliations

    • Department of Pediatrics (Neurology); University of Toronto and The Hospital for Sick Children; Toronto, Ontario, Canada
    • Corresponding Author InformationCommunications should be addressed to: Dr. Banwell; Division of Neurology; Hospital for Sick Children; 555 University Avenue; Toronto, Ontario M5G 1X8 Canada

Received 28 December 2000; accepted 5 March 2001.

Abstract 

Two brothers with a painful neuropathy as a component of late-onset GM2 gangliosidosis of the Sandhoff type are presented. A dramatic response of the severe dysesthesias to amitriptyline and gabapentin is described. Symptomatic sensory neuropathy may be a component of late-onset GM2 gangliosidosis.

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PII: S0887-8994(01)00280-6

Pediatric Neurology
Volume 25, Issue 1 , Pages 59-61, July 2001

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