Pediatric Neurology
Volume 25, Issue 1 , Pages 59-61 , July 2001

Late-Onset GM2 gangliosidosis presenting as burning dysesthesias

  • Gabriel C.S Chow, MB

      Affiliations

    • Division of Neurology; University of Toronto and The Hospital for Sick Children; Toronto, Ontario, Canada
    • ,
  • Joe T.R Clarke, MD, PhD

      Affiliations

    • Department of Paediatrics; University of Toronto and Division of Clinical Medical Genetics; The Hospital for Sick Children; Toronto, Ontario, Canada
    • ,
  • Brenda L Banwell, MD

      Affiliations

    • Department of Pediatrics (Neurology); University of Toronto and The Hospital for Sick Children; Toronto, Ontario, Canada
    • Corresponding Author InformationCommunications should be addressed to: Dr. Banwell; Division of Neurology; Hospital for Sick Children; 555 University Avenue; Toronto, Ontario M5G 1X8 Canada

Received 28 December 2000 ,Accepted 5 March 2001.

References 

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  2. Kaback MM. Tay-Sachs disease. Prog Clin Biol Res. 1977;18:197–212
  3. Gravel RA, Clarke JTR, Kaback MM, Mahuran D, Sandhoff K, Suzuki K. The GM2 gangliosidoses. In:  Scriver CR,  Beaudit AL,  Sly WS,  Valle D,  Suzuki K editor. The metabolic and molecular basis of inherited disease. New York: McGraw-Hill Inc; 1995;p. 2839–2879
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  5. Streifler JY, Gornish M, Hadar H, Gadoth N. Brain imaging in late-onset GM2 gangliosidosis. Neurology. 1993;43:2055–2058
  6. Schnorf H, Gitzelmann R, Bosshard NU, Spycher M, Waespe W. Early and severe sensory loss in three adult siblings with hexosaminidase A and B deficiency (Sandhoff disease). J Neurol Neurosurg Psychiatry. 1995;59:520–523
  7. Salman M, Clarke J, Midroni G, Waxman M. Peripheral and autonomic system involvement in chronic GM2 gangliosidosis. J Inherit Metab Dis. 2001;24:65–71
  8. Jamal GA, Hansen S, Weir A.I.Ballantyne JP. The neurophysiologic investigation of small fiber neuropathy. 1987;10:537–45.
  9. Dolman CL, MacLeod PM, Chang E. Fine structure of cutaneous nerves in ganglioside storage disease. J Neurol Neurosurg Psychiatry. 1977;40:588–594
  10. Theriault M, Dort J, Sutherland G, Zochodne DW. A prospective quantitative study of sensory deficits after whole sural nerve biopsies in diabetic and non diabetic patients (Surgical approach and the role of collateral sprouting). Neurology. 1998;50:480–484
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  12. Backonja M, Beydoun A, Edwards KR. Gabapentin monotherapy for the treatment of painful neuropathy (A multicenter, double-blind, placebo-controlled trial in patients with diabetes mellitus). JAMA. 1998;280:1831–1836
  13. Abdi S, Lee DH, Chung JM. The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain. Anesth Analg. 1998;87:1360–1366
  14. Palmeri S, Mangano L, Battisti C. Imipramine induced lipodosis and dexamethasone effect (Morphological and biochemical study in normal and chronic GM2 gangiosidosis fibroblasts). J Neurol Sci. 1992;215–221
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PII: S0887-8994(01)00280-6

Pediatric Neurology
Volume 25, Issue 1 , Pages 59-61 , July 2001

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