« Previous
Next »
Pediatric Neurology
Volume 25, Issue 2
, Pages 118-129
, August 2001
Iron and iron management proteins in neurobiology
References
- . Iron metabolism (A comprehensive review). Nutr Rev. 1996;54:295–317
- . Iron deficiency and educational deficiency. Nutr Rev. 1997;55:133–141
- . Iron in the brain. Nutr Rev. 1993;51:157–170
- . Abnormal brain monoamine metabolism in iron deficiency anemia. J Nutr Biochem. 1995;6:486–493
-
In:
Connor JR editors. Metals and oxidative damage in neurological disorders. New York: Plenum Press; 1997;
- . Iron in the brain (An important contributor in normal and diseased states). Neuroscientist. 2000;6:435–453
- . Mitochondrial dysfunction in neurodegenerative diseases. Biochim Biophys Acta. 1998;1366:211–223
- . Relationship of iron to oligodendrocytes and myelination. Glia. 1996;17:83–93
- . Effect of maternal iron deficiency on GABA shunt pathway of developing rat brain. Indian J Exp Biol. 1990;28:466–469
-
.
The role of oxidative processes and metal ions in aging and Alzheimer Disease.
In:
Connor JR editors. Metals and oxidative damage in neurological disorders. New York: Plenum Press; 1997;p. 237–276
- . Recent advances in the molecular pathogenesis of Friedreich ataxia. Hum Mol Genet. 2000;9:887–892
- . Huntingtin (an iron-regulated protein essential for normal nuclear and perinuclear organelles). Hum Mol Genet. 2000;9:2789–2797
- . A histochemical study of iron, transferrin, and ferritin in Alzheimer’s diseased brains. J Neurosci Res. 1992;31:75–83
- . Aluminum, iron and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide. J Neurochem. 1993;61:1171–1174
- . Translational regulation of the amyloid precursor protein mRNA by interleukin-1. J Biol Chem. 1999;274:6421–6431
- . Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J Neurochem. 1989;52:515–520
-
.
Pediatr Neurol. 2001;24:000–000
- . Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer’s disease. J Neurosci Res. 1992;31:327–335
- . MR evaluation of age-related increase of brain iron in young adult and older normal males. Magn Reson Imaging. 1997;15:29–35
- . A histochemical study of iron-positive cells in the developing rat brain. J Comp Neurol. 1995;355:111–123
- Normal deposition of brain iron in childhood and adolescence (MRI imaging at 1.5T). Radiology. 1989;172:381–385
-
.
Iron acquisition and expression of iron regulatory proteins in the developing brain (Manipulation by ethanol exposure, dietary deficiency and cellular dysfunction).
Dev Neurosci. 1994;6:233–247
- . Insight into the pathophysiology of restless legs syndrome. J Neurosci Res. 2000;62:623–628
- . Dopaminergic therapy in children with restless legs/periodic limb movements in sleep and ADHD. Dopaminergic Therapy Study Group. Pediatr Neurol. 2000;22:182–186
- . Iron, transferrin, and ferritin in the rat brain during development and aging. J Neurochem. 1994;63:709–716
- . Iron regulation in the developing brain (Effect of in utero ethanol exposure). J Neurochem. 1995;65:373–380
- . Brain iron (Persistent deficiency following short term iron deprivation the young rat). Br J Haematol. 1975;31:209–215
- . Brain iron in the rat (Extremely slow turnover in normal rats may explain the long lasting effects of early iron deficiency). J Nutr. 1977;107:1075–1081
- . Iron deficiency during development in the rat (Behavioral and physiological consequences). Pharmacol Biochem Behav. 1980;12:493–502
- . Long term effects of early iron deficiency on consummatory behavior in the rat. Pharmacol Biochem Behav. 1981;14:447–453
- . Variations in dietary iron alter brain iron metabolism in developing rats. J Nutr. 2000;130:254–263
- . Regional brain, iron, ferritin, and transferrin concentrations during iron deficiency and iron repletion in developing rats. J Nutr. 1997;127:2030–2038
- . Cellular Distribution of ferric iron, ferritin, transferrin and divalent metal transporter 1 (DMT1) in substantia nigra and basal ganglia of normal and β2-microglobulin deficient mouse brain. Cell Mol Biol. 2000;46:549–562
-
Nielsen JE, Jensen LN, Krabbe K. Hereditary hemochromatosis: a case of iron accumulation in the basal ganglia associated with a parkinsonian syndrome. J Neurol Neurosurg Psychiatry 1995;59:3 318–21.
- The basal ganglia in haemochromatosis. Neuroradiology. 2000;42:9–13
-
Connor JR, Milward EA, Moalem S, et al. Is hemochromatosis a risk factor for Alzheimer disease? J Alzheimer’s Dis (In press).
- . Noir de diaminobenzidine (une nouvelle methode histochemique de revelation du fer exogene). Histochemistry. 1966;66:239–244
- . Heavy metal intensification of DAB-based HRP reaction product. J Histochem Cytochem. 1981;29:775
- . Distribution of metal ions in the subcellular fractions of several rat brain areas. Life Sci. 1976;18:423–431
- . Topographical and cytological localization of iron in rat and monkey brain. Brain Res. 1981;215:317–322
- . Oligodendrocytes and myelin sheaths in normal, quaking and shiverer brains are enriched in iron. J Neurosci Res. 1991;29:413–419
- . Cellular management of iron in the brain. J Neurol Sci. 1995;134(Suppl):33–44
- Cellular distribution of iron in the brain of the Belgrade rat. Neuroscience. 1999;93:1189–1196
-
.
The development of transferrin and the transferrin receptor in relation to glial markers in the normal myelin deficient rat optic nerve.
Dev Brain Res. 1989;49:281–293
- . Pattern of myelination and distribution of neuroglial cells along the developing optic system of the rat and rabbit. J Comp Neurol. 1980;191:237–252
- . Inhibition of autoimmune neuropathological process by treatment with an iron chelating agent. J Exp Med. 1984;160:1532–1543
- . Cytokines, signal transduction, and inflammatory demyelination (review and hypothesis). Neurochem Res. 1998;23:277–289
- . Effects of TNF-α and IL-1β on iron metabolism by A459 cells and influence on cytotoxicity. Am J Physiol. 1999;277:L257–L263
- . Altered cellular distribution of iron in the CNS of myelin deficient rats. Neuroscience. 1990;34:265–271
- . Hypoxic/ischemic insult alters ferritin expression and myelination in neonatal rat brains. J Comp Neurol. 2001;431:382–396
- . Time dependent changes in iron levels and associated neuronal loss within the substantia nigra following lesions within the neostriatum/globus pallidus complex. Neuroscience. 1995;67:649–666
- . Siderotic cerebral macrophages in the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1992;116:509–516
- . Non-haem iron histochemistry of the normal and Alzheimer’s disease hippocampus. Neurodegeneration. 1994;3:267–275
- . Expression of the transferrin gene during development of non-hepatic tissues (High levels of transferrin mRNA in fetal muscle and adult brain). Biochem Biophys Res Commun. 1984;122:212–217
- . Expression of transferrin mRNA in the CNS of normal and jimpy mice. J Neurochem. 1991;57:318–322
- . Transferrin, Ferritin and Iron in selected brain regions of hypotransferrinemic mice. J Comp Neurol. 1995;355:67–80
- . Transferrin gene expression and secretion by rat brain cells in vitro. J Neurosci Res. 1990;18:299–304
- Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line. J Neurosci Res. 2000;61:388–395
- . The distribution of cerebral expression of the transferrin gene is species specific. J Biol Chem. 1991;266:1–8
-
.
High prealbumin and transferrin mRNA levels in the choroid plexus of rat brain.
Biochem Biophys Res Comm. 1985;127:890–895
- . Regional variation in the levels of transferrin in the central nervous system of normal and myelin-deficient rats. J Neurochem. 1987;49:1523–1529
-
.
Transferrin receptors in rat brain (Neuropeptide-like pattern and relationship to iron distribution).
Proc Natl Acad Sci USA. 1985;82:4553–4557
- . Characterization and distribution of transferrin receptors in the rat brain. J Neurochem. 1990;55:1972–1979
- Characterization and distribution of ferritin binding sites in the adult mouse brain. J Neurochem. 1999;72:868–874
- . Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains. J Neurol Sci. 1999;165:48–55
- . Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system. J Comp Neurol. 1996;375:675–692
- . Immunohistochemical analysis of transferrin receptor (regional and cellular distribution in the hypotransferrinemic (hpx) mouse brain). Brain Res. 1998;801:171–181
- . Histological analysis of selected brain regions of hypotransferrinemic mice. Brain Res. 1994;635:169–178
-
.
Rat transferrin gene expression (tissue-specific regulation by iron deficiency).
Proc Natl Acad Sci USA. 1986;83:3723–3727
- . Transferrin response in normal and iron deficient mice heterozygotic for hypotransferrinemia (effects on iron and manganese accumulation). BioMetals. 1998;11:265–276
-
Evidence that H- and L-chains have cooperative roles in the iron-uptake mechanism of human ferritin.
Biochem J. 1992;288:591–596
- . A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzeimer’s diseased brains. J Neurochem. 1995;65:717–724
- . Iron deficiency alters H and L ferritin subunits in rat brain. Cell Mol Biol. 2000;46:517–528
- . Isoforms of ferritin have a specific cellular distribution in the brain. J Neurosci Res. 1994;37:461–465
- . Messenger RNAs located in myelin sheath assembly sites. J Neurochem. 2000;75:1834–1844
- Iron metabolism and human ferritin heavy chain cDNA from adult brain with an elongated untranslated region (New findings and insights). Analyst. 1998;123:41–50
- . Cellular distribution of ferritin subunits in postnatal rat brain. J Comp Neurol. 1998;400:73–86
- . Differential expression of the heavy chain ferritin gene in non-adhered and adhered oligodendrocytes. J Neurosci Res. 1996;46:187–197
- . Regional distribution of iron, transferrin, ferritin and oxidatively modified proteins in young and aged Fischer 344 rat brains. Neuroscience. 1997;79:255–261
-
Hu J, Connor JR. Characterization and identification of the iron regulatory protein in the brain. J Neurochem 1996;1996:67:838–44.
- . Abnormal localization of iron regulatory protein in Alzheimer’s disease. Brain Res. 1998;788:232–236
- . Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer’s diseased brains. Cell Mol Biol (Noisy-Le-Grand). 2000;46:761–776
- . Iron uptake by mammalian cortical neurons. Ann Neurol. 1984;16:66–70
-
Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson’s disease.
Proc Natl Acad Sci USA. 1995;92:9603–9607
-
.
Transient expression of transferrin receptors and localization of iron in amoeboid microglia in postnatal rats.
J Anat. 1995;186:165–173
- . Transferrin receptor on endothelium of brain capillaries. Nature. 1984;312:162–163
- . Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res. 1987;18:299–304
-
.
Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells.
Am J Physiol. 1996;270:1149–1158
- . Iron and transferrin uptake by brain and cerebrospinal fluid in the rat. Brain Res. 1992;592:8–16
- . Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier. Brain Res Bull. 1988;21:881–885
-
.
Receptor-mediated endocytosis of transferrin at the blood-brain barrier.
J Cell Sci. 1993;104:521–532
- Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997;388:482–488
-
.
Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents.
Am J Physiol. 1996;270:826–832
- . Brain uptake of trace metals, zinc and manganese, in rats. Brain Res. 1994;640:341–344
- . Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain. J Neurol Sci. 1999;170:112–118
- . Effects of diet and development upon the uptake and distribution of cerebral iron. J Neurol Sci. 1995;134(Suppl):45–51
- Cerebral blood volume measured using near-infrared spectroscopy and radiolabels in the immature lamb brain. Pediatr Res. 1999;46:50–56
- . Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology. 2000;54:1698–1700
- . Ferritin, transferrin and iron concentrations in the cerebrospinal fluid of multiple sclerosis patients. Brain Res. 1999;821:511–515
- . Transcytosis of protein through the mammalian cerebral epithelium and endothelium. III. Receptor-mediated transcytosis through the blood-brain barrier of blood-borne transferrin and antibody against the transferrin receptor. Exp Neurol. 1996;142:47–65
- . Ferritin, transferrin, and iron in selected regions of the adult and aged rat brain. J Comp Neurol. 1993;338:97–113
- . Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system. J Comp Neurol. 1996;375:675–692
- . Kinetics and distribution of [59Fe-125I]transferrin injected into the ventricular system of the rat. Brain Res. 1998;790:115–128
- . Distribution of injected 59Fe and 54Mn in hypotransferrinemic mice. J Lab Clin Med. 1996;128:270–278
PII: S0887-8994(01)00303-4
© 2001 Elsevier Science Inc. All rights reserved.
« Previous
Next »
Pediatric Neurology
Volume 25, Issue 2
, Pages 118-129
, August 2001
