Pediatric Neurology
Volume 25, Issue 3 , Pages 221-226 , September 2001

Characteristic neuropathology and plasticity in periventricular leukomalacia

  • Yumi Okoshi, MD

      Affiliations

    • Department of Pediatric Neurology, National Center for Mental, Nervous and Muscular Disorders, Tokyo, Japan
    • ,
  • Masayuki Itoh, MD

      Affiliations

    • National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    • ,
  • Sachio Takashima, MD

      Affiliations

    • National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    • Corresponding Author InformationCommunications should be addressed to: Dr. Takashima; National Institute of Neuroscience; National Center of Neurology and Psychiatry; 4-1-1 Ogawahigashi, Kodaira; Tokyo 187-8551, Japan

Received 3 January 2001 ,Accepted 2 May 2001.

References 

  1. Deguchi K, Oguchi K, Matsuura N, Armstrong D, Takashima S. Periventricular leukomalacia (Relation to gestational age and axonal injury). Pediatr Neurol. 1999;20:370–374
  2. Inage K, Itoh M, Takashima S. Correlation between cerebrovascular maturity and periventricular leukomalacia. Pediatr Neurol. 2000;22:204–208
  3. Deguchi K, Oguchi K, Takashima S. Characteristic neuropathology of leukomalacia in extremely low birth weight infants. Pediatr Neurol. 1997;16:296–300
  4. Iida K, Takashima S, Takeuchi Y. Etiology and distribution of neonatal leukomalacia. Pediatr Neurol. 1992;8:205–209
  5. Iida K, Takashima S, Takeuchi Y, Ohno T, Ueda K. Neuropathologic study of newborns with prenatal-onset leukomalacia. Pediatr Neurol. 1993;9:45–48
  6. Armstrong D, Norman MB. Periventricular leukomalacia in neonates. Arch Dis Child. 1974;49:367–375
  7. Cioni G, Fazzi B, Coluccini M, Bartalena L, Boldrini A, Hof van Duin J. Cerebral visual impairment in preterm infants with periventricular leukomalacia. Pediatr Neurol. 1997;17:331–338
  8. Nieuwenhuys R, Voogd J, Huijzen Chr. The human central nervous system. Berlin: Springer-Verlag, 1988:365–75.
  9. Iai M, Takashima S. Thalamocortical development of parvalmin neurons in normal and periventricular leukomalacia brains. Neuropediatricus. 1999;30:14–18
  10. Lendahl U, Zimmerman LB, McKay RDG. CNS stem cells express a new class of intermediate filament protein. Cell. 1990;60:585–595
  11. Frederiksen K, McKay RDG. Proliferation and differentiation of rat neuroepithelial precursor cells in vivo. J Neurosci. 1988;8:1144–1151
  12. Duggal N, Schmidt-Kastner R, Hakim AM. Nestin expression in reactive astrocytes following focal cerebral ischemia in rats. Brain Res. 1997;768:1–9
  13. Clarke SR, Shetty AK, Bradley JL, Turner DA. Reactive astrocytes express the embryonic intermediate neurofilament nestin. Neuroreport. 1994;5:1885–1888

PII: S0887-8994(01)00309-5

Pediatric Neurology
Volume 25, Issue 3 , Pages 221-226 , September 2001

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