Pediatric Neurology
Volume 25, Issue 3 , Pages 208-212 , September 2001

Efficacy of the ketogenic diet in focal versus generalized seizures

  • Bernhard V Maydell, MD

      Affiliations

    • Department of Neurology; The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
  • ,
  • Elaine Wyllie, MD

      Affiliations

    • Department of Neurology; The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    • Corresponding Author InformationCommunications should be addressed to: Dr. Wyllie; Head, Section of Pediatric Epilepsy; The Cleveland Clinic Foundation; Department of Neurology; Desk S 51; 9500 Euclid Avenue; Cleveland, OH 44195
  • ,
  • Nadia Akhtar, MD

      Affiliations

    • Department of Neurology; The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
  • ,
  • Prakash Kotagal, MD

      Affiliations

    • Department of Neurology; The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
  • ,
  • Kathy Powaski, RN

      Affiliations

    • Department of Neurology; The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
  • ,
  • Karen Cook, MEd, RD

      Affiliations

    • Department of Neurology; The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
  • ,
  • Arie Weinstock, MD

      Affiliations

    • Department of Neurology; The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
  • ,
  • A.David Rothner, MD

      Affiliations

    • Department of Neurology; The Cleveland Clinic Foundation, Cleveland, OH 44195, USA

Received 17 January 2001 ,Accepted 2 May 2001.

References 

  1. Geyelin HR. Fasting as a method for treating epilepsy. Med Rec. 1921;99:1037–1039
  2. Wilder RM. The effects of ketonemia on the course of epilepsy. Mayo Clin Proc. 1921;2:307–308
  3. Schwartzkroin PA. Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet. Epilepsy Res. 1999;37:171–180
  4. Schwartz RM, Eaton J, Bower BD, Aynnsley-Green A. Ketogenic diets in the treatment of epilepsy (Short-term clinical effects). Dev Med Child Neurol. 1989;31:145–151
  5. Kinsman SL, Vining EPG, Quaskey SA, Mellits D, Freeman JM. Efficacy of the ketogenic diet for intractable seizure disorders (Review of 58 cases). Epilepsia. 1992;33:1132–1136
  6. Prasad AN, Stafstrom CF, Holmes GL. Alternative epilepsy therapies (the ketogenic diet, immunoglobulins, and steroids). Epilepsia. 1996;37(Suppl 1):S81–S95
  7. Swink TD, Vining EPG, Freeman JM. The ketogenic diet 1997. Adv Pediatr. 1997;44:297–329
  8. Nordli DR, De Vivo DC. The ketogenic diet revisited (Back to the future). Epilepsia. 1997;38:743–749
  9. Vining EPG. Clinical efficacy of the ketogenic diet. Epilepsy Res. 1999;7:181–190
  10. Nigro MA, Ventimiglia J, Selcen D, Beierwaltes P. Seizure frequency, behavioral, and performance effects on the ketogenic diet. Ann Neurol. 1995;38:549–550
  11. Pulsifer MB, Gordon JM, Brandt J, Vining EP, Freeman JM. Effects of ketogenic diet on development and behavior (Preliminary report of a prospective study). Dev Med Child Neurol. 2001;43:301–306
  12. Freeman JM, Vining EPG, Pillas DJ, Pyzik PL, Casey JC, Kelly MT. The efficacy of the ketogenic diet-1998; a prospective evaluation of intervention in 150 children. Pediatrics. 1998;102:1358–1363
  13. Vining EPG, Freeman JM, Ballaban-Gil K, et al.  A multicenter study of the efficacy of the ketogenic diet. Arch Neurol. 1998;55:1433–1437
  14. Hassan AM, Keene DL, Whiting SE, Jacob PJ, Champagne JR, Humphreys P. Ketogenic diet in the treatment of refractory epilepsy in childhood. Pediatr Neurol. 1999;21:548–552
  15. Freeman JM, Kelly MT, Freeman JB. The epilepsy diet treatment: An introduction to the ketogenic diet. New York: Demos, 1994:133–51.
  16. Schachter SC, Saper CB. Vagus nerve stimulation. Epilepsia. 1998;39:677–686
  17. Livingston S, Pauli LL, Pruce I. Ketogenic diet in the treatment of childhood epilepsy. Dev Med Child Neurol. 1977;19:833–834
  18. Sirven J, Whedon B, Caplan D, et al.  The ketogenic diet for intractable epilepsy in adults (preliminary results). Epilepsia. 1999;40:1721–1726
  19. Janaki S, Rashid MK, Galati MS, Jayaram SR, Baruah JK, Saxena VK. A clinical electroencephalographic correlation of seizures on a ketogenic diet. Indian J Med Res. 1976;64:1057–1063
  20. Huttenlocher PR. Ketonemia and seizures (Metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy). Pediatr Res. 1976;10:536–540
  21. Sills MA, Forsythe WI, Haidukewych D, MacDonald A, Robinson M. The medium-chain triglyceride diet and intractable epilepsy. Arch Dis Child. 1986;61:116–117
  22. Berqvist AG, Chee CM, Lutcha LM, Brooks-Kayal AR. Treatment of acquired epileptic aphasia with the ketogenic diet. J Child Neurol. 1999;14:696–701
  23. Nordli DR, Koenigsberger D, Carroll J, De Vivo DC. Successful treatment of infants with the ketogenic diet. Ann Neurol. 1995;38:523
  24. Herzberg GZ, Fivush BA, Kinsman SL, Gearhardt JP. Urolithiasis associated with the ketogenic diet. J Peds. 1990;117:743–745
  25. Chez MG, Buchanon C, Kessler J, Demski P, Wagner E. Carnitine deficiency in patients starting the ketogenic diet. Neurology. 1997;48:A110
  26. Ballaban-Gil K, Callahan C, O’Dell C, Pappo M, Moshe S, Shinnar S. Complications of the ketogenic diet. Epilepsia. 1998;39:744–748
  27. Thompson JA, Van Orman CB, Peterson P. Ketogenic diet (Long-term efficacy and patient tolerance in children with intractable pediatric epilepsy). (Abstract) Ann Neurol. 1999;46:532

PII: S0887-8994(01)00310-1

Pediatric Neurology
Volume 25, Issue 3 , Pages 208-212 , September 2001