Pediatric Neurology
Volume 25, Issue 4 , Pages 304-308, October 2001

Hypermagnesemia does not increase brain intracellular magnesium in newborn swine

  • Jerry B Gee II, MD

      Affiliations

    • Texas Women’s Hospital, Houston, Texas, USA
    • ,
  • Ronald J.T Corbett, MD

      Affiliations

    • Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    • ,
  • Jeffrey M Perlman, MD

      Affiliations

    • Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    • ,
  • Abbot R Laptook, MD

      Affiliations

    • Corresponding Author InformationCommunications should be addressed to: Dr. Laptook; Department of Pediatrics; University of Texas Southwestern Medical Center at Dallas; 5323 Harry Hines Boulevard; Dallas, TX 75390-9063
    • Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

Received 4 December 2000; accepted 16 May 2001.

Abstract 

Phosphorus-31 magnetic resonance spectroscopy was used in 2-day (n = 4) and 40-day (n = 4) miniswine to determine whether plasma hypermagnesemia alters brain intracellular magnesium concentration and if the plasma-brain intracellular magnesium relationship changes with age. At control, brain intracellular magnesium concentration was similar in the 2-day (0.24 ± 0.04 mM) and 40-day groups (0.21 ± 0.01 mM). Intravenous infusions of magnesium sulfate (MgSO4, 60 minute) raised plasma magnesium concentration to 4-6 mM in both groups. During and for 3 hours after MgSO4 infusions, there were no changes in brain intracellular magnesium concentration in either group and no correlation between plasma and brain intracellular magnesium (r = 0.11 and 0.08 for 2- and 40-day groups, respectively). Brain intracellular magnesium concentration appears to be tightly regulated.

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PII: S0887-8994(01)00317-4

Pediatric Neurology
Volume 25, Issue 4 , Pages 304-308, October 2001

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