Pediatric Neurology
Volume 25, Issue 4 , Pages 304-308 , October 2001

Hypermagnesemia does not increase brain intracellular magnesium in newborn swine

  • Jerry B Gee II, MD

      Affiliations

    • Texas Women’s Hospital, Houston, Texas, USA
    • ,
  • Ronald J.T Corbett, MD

      Affiliations

    • Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Department of Radiology University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    • ,
  • Jeffrey M Perlman, MD

      Affiliations

    • Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    • ,
  • Abbot R Laptook, MD

      Affiliations

    • Corresponding Author InformationCommunications should be addressed to: Dr. Laptook; Department of Pediatrics; University of Texas Southwestern Medical Center at Dallas; 5323 Harry Hines Boulevard; Dallas, TX 75390-9063
    • Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

Received 4 December 2000 ,Accepted 16 May 2001.

References 

  1. Altura BM, Altura BT, Gebrewold A, Ising H, Günther T. Magnesium deficiency and hypertension (Correlation between magnesium deficient diets and microcirculatory changes in situ). Science. 1984;223:1315–1317
  2. Altura BM, Gebrewold A, Altura BT, Gupta RK. Role of brain [Mg+2]i in alcohol-induced hemorrhagic stroke in a rat model (A 31P-NMR in vivo study). Alcohol. 1995;12:131–136
  3. Altura BM, Gupta RK. Cocaine induces intracellular free Mg deficits, ischemia and stroke as observed by in vivo 31P-NMR of the brain. Biochem Biophys Acta. 1992;1111:271–273
  4. Vink R, Heath DL, McIntosh TK. Acute and prolonged alterations in brain free magnesium following fluid percussion-induced brain trauma in rats. J Neurochem. 1996;66:2477–2483
  5. Vink R, McIntosh TK, Demediuk P, Weiner MW, Faden AI. Decline in intracellular free Mg+2 is associated with irreversible tissue injury after brain trauma. Biol Chem. 1988;263:757–761
  6. Nelson KB, Grether JK. Can magnesium sulfate reduce the risk of cerebral palsy in very low birth weight infants?. Pediatrics. 1995;95:263–269
  7. Schendel DE, Berg CJ, Yeargin-Allsopp M, Boyle CA, Decoufle P. Prenatal magnesium sulfate exposure and the risk for cerebral palsy or mental retardation among very low birth weight children aged 3 to 5 years. JAMA. 1996;276:1805–1810
  8. Gee JB, Corbett RJT, Perlman JM, Garcia D, Laptook AR. Age dependent differences in the relationship between plasma and brain extracellular fluid concentrations of magnesium after MgSO4 infusions in miniswine. Pediatr Res. 1999;46:281–286
  9. Corbett RJT, Laptook AR, Garcia D, Ruley JI. Energy reserves and utilization rates in developing brain measured in vivo by 31P and 31H nuclear magnetic resonance spectroscopy. J Cereb Blood Flow Metab. 1993;13:235–246
  10. Corbett RJT, Gee J, Laptook AR. Calculation of intracellular cerebral [Mg+2] during hypoxic ischemia by in vivo 31P NMR. Neuroreport. 1996;8:287–291
  11. Corbett RJT, Laptook AR, Nunnally RL. The use of the chemical shift of the phosphomonoester P-31 magnetic resonance peak for the determination of intracellular pH in the brains of neonates. Neurology. 1987;37:1771–1779
  12. McDonald JW, Silverstein FS, Johnston MV. Magnesium reduces N-methyl-D-aspartate (NMDA) mediated brain injury in perinatal rats. Neurosci Lett. 1990;109:234–238
  13. Melchior JB. The role of metal ions in the pyruvic kinase reaction. Biochem. 1965;4:1515–1525
  14. Altura BM, Altura BT, Carella A, Gebrewold A, Murakawa ST, Nishio A. Mg+2-Ca+2 interaction in contractility of vascular smooth muscle (Mg+2 versus organic calcium channel blockers on myogenic tone and agonist-induced responsiveness of blood vessels). Can J Physiol Pharmacol. 1987;65:729–745
  15. Chiesi M, Inesi G. Mg+2 and Mn+2 modulation of Ca+2 transport and ATPase activity in sarcoplasmic reticulum vesicles. Arch Biochem Biophys. 1981;208:586–592
  16. Standley CA, Cotton DB. Brain ionized magnesium and calcium levels during magnesium supplementation and deficiency in female Long-Evans Rats. Obstet Gynecol. 1996;88:184–188
  17. Heath DL, Vink R. Neuroprotective effects of MgSO4 and MgCl2 in closed head injury (A comparative phosphorus NMR study). J Neurotrauma. 1998;15:183–189
  18. Brooks KJ, Bachelard HS. Changes in intracellular free magnesium during hypoglycemia and hypoxia in cerebral tissue as calculated from 31P nuclear magnetic resonance spectra. J Neurochem. 1989;53:331–334
  19. Helpern JA, Linde V, Welch KMA, et al.  Acute elevation and recovery of intracellular [Mg+2] following human focal cerebral ischemia. Neurology. 1993;43:1577–1581
  20. Rajdev S, Reynolds IJ. Calcium influx but not pH or ATP level mediates glutamate-induced changes in intracellular magnesium in cortical neurons. J Neurophysiol. 1995;74:942–949

PII: S0887-8994(01)00317-4

Pediatric Neurology
Volume 25, Issue 4 , Pages 304-308 , October 2001

Article Tools

* Image Usage & Resolution