Pediatric Neurology
Volume 25, Issue 4 , Pages 340-343, October 2001

Possible induction of systemic lupus erythematosus by zonisamide

  • Kozo Mutoh, MD

      Affiliations

    • Corresponding Author InformationCommunications should be addressed to: Dr. Mutoh; Department of Pediatrics; Shimada Municipal Hospital; 1200-5 Noda; Shimada 427, Japan
    • Department of Pediatrics; Shimada Municipal Hospital; 1200-5 Noda; Shimada 427, Japan
    • ,
  • Yoshihiko Hidaka, MD

      Affiliations

    • Department of Pediatrics; Shimada Municipal Hospital; 1200-5 Noda; Shimada 427, Japan
    • ,
  • Yasuyuki Hirose, MD

      Affiliations

    • Department of Pediatrics; Shimada Municipal Hospital; 1200-5 Noda; Shimada 427, Japan
    • ,
  • Mitsuaki Kimura, MD

      Affiliations

    • Department of Allergy and Clinical Immunology; Shizuoka Children’s Hospital; Shizuoka, Japan

Received 21 February 2001; accepted 31 May 2001.

Abstract 

An epileptic male to whom zonisamide and ethosuximide had been administered exhibited fever, pericarditis, pleuritis, arthralgia, and elevated titers of antinuclear antibody and anti-DNA-antibody at 5 years, 11 months of age. It was suggested that zonisamide induced the systemic lupus erythematosus symptoms because the antinuclear antibody titers began to rise after zonisamide was administered, and clinical recovery and a decrease in the anti-DNA-antibody levels promptly followed the discontinuation of the drug. The positive lymphocyte transformation test results against zonisamide further supports the etiologic relationship of the male’s lupus and the drug. This first case of zonisamide-induced lupus should alert physicians to the possibility of this serious unwanted effect in patients receiving zonisamide.

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PII: S0887-8994(01)00325-3

Pediatric Neurology
Volume 25, Issue 4 , Pages 340-343, October 2001

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