Pediatric Neurology
Volume 26, Issue 3 , Pages 219-221, March 2002

Hematogenous brain metastasis in children

  • Richard G Curless, MD

      Affiliations

    • Corresponding Author InformationCommunications should be addressed to: Dr. Curless; Department of Neurology (M-712); University of Miami School of Medicine; P.O. Box 016960; Miami, FL 33101 USA
    • Department of Neurology; University of Miami School of Medicine; Miami, Florida, USA
    • ,
  • Stuart R Toledano, MD

      Affiliations

    • Department of Pediatrics; University of Miami School of Medicine; Miami, Florida, USA
    • ,
  • John Ragheb, MD

      Affiliations

    • Department of Neurosurgery; University of Miami School of Medicine; Miami, Florida, USA
    • ,
  • William W Cleveland, MD

      Affiliations

    • Department of Pediatrics; University of Miami School of Medicine; Miami, Florida, USA
    • ,
  • Steven Falcone, MD

      Affiliations

    • Department of Radiology; University of Miami School of Medicine; Miami, Florida, USA

Received 22 May 2001; accepted 4 September 2001.

Abstract 

Hematogenous brain metastases are uncommon in childhood. Three patients and a literature review that includes centers reporting up to 36 years of experience are presented in this study. The total of 2,040 patients includes our three examples of one neuroblastoma, one hepatoblastoma, and one adrenal carcinoma. Cerebral hematogenous metastases were reported in 4.4% of 429 patients with neuroblastoma, 1.9% of 574 rhabdomyosarcoma patients, 6.5% of 386 patients with osteosarcoma, 3.3% of 487 Ewing sarcoma patients, 3.6% of 44 melanoma patients, 13.5% of 37 patients with germ cell tumors, and 1.3% of the 78 patients with Wilms tumor. Five miscellaneous patients included three with a hepatoblastoma and one each with adrenal carcinoma and nephroma. All of the large series reports have been published in oncology journals.

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PII: S0887-8994(01)00363-0

Pediatric Neurology
Volume 26, Issue 3 , Pages 219-221, March 2002

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