Pediatric Neurology
Volume 26, Issue 3 , Pages 222-224 , March 2002

Oral high-dose phenobarbital therapy for early infantile epileptic encephalopathy

  • Hiroshi Ozawa, MD

      Affiliations

    • Corresponding Author InformationCommunications should be addressed to: Dr. Ozawa; Department of Pediatrics; Tokyo Metropolitan Hachioji Children’s Hospital; 4-33-13, Daimachi, Hachioji; Tokyo 193-0931, Japan
    • Department of Pediatrics; Tokyo Metropolitan Hachioji Children’s Hospital; Hachioji; Tokyo, Japan
    • ,
  • Yuko Kawada, MD

      Affiliations

    • Department of Pediatrics; Tokyo Metropolitan Hachioji Children’s Hospital; Hachioji; Tokyo, Japan
    • ,
  • Seiji Noma, MD

      Affiliations

    • Department of Pediatrics; Tokyo Metropolitan Hachioji Children’s Hospital; Hachioji; Tokyo, Japan
    • ,
  • Kenji Sugai, MD

      Affiliations

    • Department of Child Neurology; National Center Hospital for Mental, Nervous and Muscular Disorders; National Center of Neurology and Psychiatry; Kodaira, Tokyo, Japan

Received 27 February 2001 ,Accepted 24 August 2001.

References 

  1. Ohtahara S, Ishida T, Oka E, Yamatogi Y, Inoue H. On the specific age-dependent epileptic syndrome. The early-infantile epileptic encephalopathy with suppression burst. No To Hattatsu (Tokyo). 1976;8:271–279
  2. Ohtahara S. Clinico-electrical delineation of epileptic encephalopathies in childhood. Asian Med J. 1978;21:499–509
  3. Ohtahara S, Ohtsuka Y, Yamatogi Y, Oka E, Inoue E. Early-infantile epileptic encephalopathy with suppression-bursts. In:  Roger J,  Bureau M,  Dravet CH,  Dreifuss FE,  Perret A,  Wolf P editor. Epileptic syndromes in infancy, childhood, and adolescence. 2nd ed.. London: John Libbey; 1992;p. 25–34
  4. Pedespan JM, Loiseau H, Vital A, Marchal C, Fontan D, Rougier A. Surgical treatment of an early epileptic encephalopathy with suppression-bursts and focal cortical dysplasia. Epilepsia. 1995;36:37–40
  5. Komaki H, Sugai K, Sasaki M, et al.  Surgical treatment of a case of early infantile epileptic encephalopathy with suppression-bursts associated with focal cortical dysplasia. Epilepsia. 1999;40:365–369
  6. Takusa Y, Ito M, Kobayashi A, Sejima H, Kishi K, Shiraishi H. Effect of the ketogenic diet for West syndrome into which early infantile epileptic encephalopathy with suppression-burst was evoked. No to Hattatsu (Tokyo). 1995;27:383–387
  7. Yoshikawa H, Ikeda S, Watanabe T. Liposteroid therapy in a case of early infantile epileptic encephalopathy with suppression-burst. No to Hattatsu (Tokyo). 1998;30:551–554
  8. Crawford TO, Mitchell WG, Fishman LS, Snodgrass SR. Very-high-dose phenobarbital for refractory status epilepticus in children. Neurology. 1988;38:1035–1040
  9. Gilman JT, Gal P, Duchowny MS, Weaver RL, Ransom JL. Rapid sequential phenobarbital treatment of neonatal seizures. Pediatrics. 1989;83:674–678
  10. Hall RT, Hall FK, Daily DK. High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia (A randomized, prospective study with three-year follow-up). J Pediatr. 1998;132:345–348
  11. Nilsson L. The influence of barbiturate anaesthesia upon the energy state and upon acid-base parameters of the brain in arterial hypotension and in asphyxia. Acta Neurol Scand. 1971;47:233–253

PII: S0887-8994(01)00365-4

Pediatric Neurology
Volume 26, Issue 3 , Pages 222-224 , March 2002

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