Pediatric Neurology
Volume 28, Issue 1 , Pages 16-19 , January 2003

Nitrazepam for the treatment oflennox-gastaut syndrome

  • Syed A Hosain, MD

      Affiliations

    • Weill Medical College of Cornell University, New York, New York, USA.
    • Corresponding Author InformationCommunications should be addressed to: Dr. Hosain; The Comprehensive Epilepsy Center; New York Presbyterian Hospital; 525 East Sixty-Eighth Street-K619; New York, NY 10021, USA.
    • ,
  • Novette S Green, BSN

      Affiliations

    • Weill Medical College of Cornell University, New York, New York, USA.
    • ,
  • Gail E Solomon, MD

      Affiliations

    • Weill Medical College of Cornell University, New York, New York, USA.
    • ,
  • Abe Chutorian, MD

      Affiliations

    • Weill Medical College of Cornell University, New York, New York, USA.

Received 19 February 2002 ,Accepted 4 June 2002.

References 

  1. Hauser WA, Hesdorffer DC. Seizures and the developmental disabilities. In:  Hauser WA,  Hesdorffer DC editor. Epilepsy (Frequency, causes and consequences). New York: Demos; 1990;p. 327–357
  2. Donat JF. The age-dependent epileptic encephalopathies. J Child Neurol. 1992;7:7–21
  3. Gastaut H, Roger J, Soulayrol R, et al.  Childhood epileptic encephalopathy with diffuse slow spike-waves. Epilepsia. 1966;7:139–179
  4. Blume WT, David RB, Gomez MR. Generalized sharp and slow wave complexes-associated clinical features and long-term follow-up. Brain. 1973;96:289–306
  5. Chevrie JJ, Aicardi J. Childhood epileptic encephalopathy with slow spike-wave. Epilepsia. 1972;13:259–271
  6. Yagub BA. Electroclinical seizures in Lennox-Gastaut syndrome. Epilepsia. 1993;34:120–127
  7. Markand ON. Slow spike-wave activity in EEG and associated clinical features. Neurology. 1977;27:746–757
  8. Dulac O, N’Guyen T. The Lennox-Gastaut syndrome. Epilepsia. 1993;34(Suppl 7):S7–17
  9. Swink TD, Vining EP, Freeman JM. The ketogenic diet. Adv Pediatr. 1997;44:297–329
  10. Morton LD, Pellock JM. Diagnosis and treatment of epilepsy in children and adolescent. Drugs. 1996;51:399–414
  11. Jan JE, Riegl JA, Crichton JU, Dunn HG. Nitrazepam in the treatment of epilepsy in childhood. Can Med Assoc J. 1971;104:571–575
  12. Liske E, Forster FM. Clinical study of a new benzodiazepine as an anticonvulsant agent. JN Drugs. 1963;3:241–244
  13. Browne TR, Penry JK. Benzodiazepines in the treatment of epilepsy (A review). Epilepsia. 1973;14:277–310
  14. Baruzzi A, Michelucci R, Tassinari FA. Benzodiazepines, nitrazepam. In:  Levy RH,  Dreifuss FE,  Mattson RH,  Meldrum BS,  Penry KK editor. Antiepileptic drugs. 3rd ed. New York: Raven Press; 1989;p. 785–804
  15. Murphy JV, Sawasky F, Marquardt KM, Harris DJ. Deaths in young children receiving nitrazepam. J Pediatr. 1987;111:145–147
  16. Rintahaka PJ, Nakegawa JA, Shewmom DA, Kyynnem P, Shields WD. Incidence of death in patients with intractable epilepsy, during nitrazepam treatment. Epilepsia. 1994;40:492–496
  17. Chamberlain MC. Nitrazepam for refractory infantile spasms and the Lennox-Gastaut syndrome. J Child Neurol. 1996;11:31–34
  18. Millichap JG, Ortiz WR. Nitrazepam in myoclonic epilepsies. Am J Dis Child. 1966;112:242–248
  19. Gibbs FA, Anderson EM. Treatment of hypsarrhythmia and infantile spasms with a Librium analogue. Neurology. 1965;15:1173–1176
  20. Dreifuss F, Farwell J, Holmes G, et al.  Infantile spasms. Comparative trial of nitrazepam and corticotrophin. Arch Neurol. 1986;43:1107–1110
  21. Motte J, Trevathan E, Arvidsson JFV, Barrera MN, Mullens EL, Manasco P. Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. N Engl J Med. 1997;337:1807–1812
  22. Culy CR, Goa KL. Lomotrigine. A review of its use in childhood epilepsy. Paediatr Drugs. 2000;2:299–330
  23. The Felbamate Study Group in Lennox-Gastaut syndrome . Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome). N Engl J Med. 1993;328:29–33
  24. Ritter FJ, Glauser TA, Sacheo RC, Wu Sc  YL Study Group . Topiramate as long-term therapy in Lennox-Gastaut syndrome. The YL Study Group (abstract S32.003). Neurology. 1998;50(Suppl 4):A312
  25. Bebin EM, Sofia RD, Dreifuss FE. Felbamate. In:  Levy RH,  Mattson RH,  Meldrum BS editor. Antiepileptic drugs. 4th ed. New York: Raven Press; 1995;p. 823–827
  26. French JA, Bourgeois BFD, Dreifuss FE, et al.  An open-label multicenter study of topiramate in patients with the Lennox-Gastaut syndrome (abstract). Neurology. 1995;45(Suppl 4):A250
  27. Glauser TA. Topiramate. Semin Pediatr Neurol. 1997;4:34–42
  28. Hosain S, Nikolov B, Harden C, Li M, Fraser R, Labar D. Vagus nerve stimulation treatment for Lennox-Gastaut syndrome. J Child Neurol. 2000;15:509–512

PII: S0887-8994(02)00461-7

doi: 10.1016/S0887-8994(02)00461-7

Pediatric Neurology
Volume 28, Issue 1 , Pages 16-19 , January 2003

Article Tools