Pediatric Neurology
Volume 28, Issue 1 , Pages 20-23 , January 2003

Serotonin-related tryptophan in children with insulin-dependent diabetes

  • Rocı́o Herrera, MD

      Affiliations

    • Laboratory of Neurochemistry, XXI Century, National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico
    • ,
  • Gabriel Manjarrez, PhD

      Affiliations

    • Laboratory of Neurochemistry, XXI Century, National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico
    • Corresponding Author InformationCommunications should be addressed to: Dr. Manjarrez; Laboratory of Neurochemistry; Specialties Hospital; XXI Century; National Medical Center; Mexican Institute of Social Security; Av. Cuauhtémoc 330; Col. Doctores; CP 06720, Mexico City, Mexico.
    • ,
  • Elisa Nishimura, MD

      Affiliations

    • Service of Endocrinology, Pediatric Hospital; XXI Century, National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico
    • ,
  • Jorge Hernandez, PhD

      Affiliations

    • Laboratory of Neurontogeny, Department of Physiology, Biophysics and Neurosciences, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, México; and the Facultad de Medicina, Universidad Autónoma de Querétaro, Queretaro City, Queretaro, México, Mexico.

Received 11 October 2001 ,Accepted 12 June 2002.

References 

  1. Jacobs BL, Azmitia EC. Structure and function of the brain serotonin system. Physiol Rev. 1992;72:165–229
  2. Olson L, Boreus LO, Seiger A. Histochemical demonstration and mapping of 5-hydroxytryptamine and catecholamine-containing neuron systems in the human fetal brain. Z Anat Entwicklungsgesch. 1973;139:259–282
  3. Takahashi H, Nakashima S, Ohama E, Takeda S, Ikuta F. Distribution of serotonin-containing cell bodies in the brainstem of the human fetus determined with immunohistochemistry using antiserotonin serum. Brain Dev. 1986;8:355–365
  4. Andrade R. Regulation of membrane excitability in the central nervous system by serotonin receptor subtypes. Ann NY Acad Sci. 1998;861:190–203
  5. Choi DS, Kellerman O, Richard S, et al.  Mouse 5HT2B receptor-mediated serotonin trophic functions. Ann NY Acad Sci. 1998;861:67–78
  6. Lavdas AA, Blue ME, Lincoln J, Parnavelas JG. Serotonin promotes the differentiation of glutamate neurons in organotypic slice cultures of the developing cerebral cortex. J Neurosci. 1997;17:7872–7880
  7. Rörig B, Sutor B. Serotonin regulates gap junction coupling in the developing rat somatosensory cortex. Eur J Neurosci. 1996;8:1685–1695
  8. Jouvet M. Sleep and serotonin (An unfinished story). Neuropsychopharmacology. 1999;21:24S–27S
  9. Shor-Posner G, Grinker AJ, Marinescu C, Brown O, Leibowitz FS. Hypothalamic serotonin in the control of meal patterns and macronutrient selection. Brain Res Bull. 1986;17:663–671
  10. Mann JJ. Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology. 1999;21:99S–105S
  11. Blier P, De Montigny C. Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders. Neuropsychopharmacology. 1999;21:91S–98S
  12. Abi-Dargham A, Laruelle M, Aghajanian GK. The role of serotonin in the pathophysiology and treatment of schizophrenia. J Neuropsy Clin Neurosci. 1997;9:1–17
  13. Meltzer HY. The role of serotonin in antipsychotic drug action. Neuropsychopharmacology. 1999;21:106S–115S
  14. McMenamy RH, Oncley JL. The specific binding of L-tryptophan to serum albumin. J Biol Chem. 1975;233:1436–1447
  15. Boadle-Biber MC. Regulation of serotonin synthesis. Prog Biophys Mol Biol. 1993;60:1–15
  16. Yuwiler A, Oldendorf WH, Geller E, Braun L. Effects of albumin binding and amino acid competition on tryptophan uptake into brain. J Neurochem. 1977;28:1015–1023
  17. Pardridge WM. Tryptophan transport through the blood-brain barrier (In vivo measurement of free and albumin-bound amino acid). Life Sci. 1979;25:1519–1528
  18. Oldendorf WH. Brain uptake of radiolabeled amino acids, amines and hexoses after arterial injection. Am J Physiol. 1971;221:1629–1639
  19. Crandall EA, Gillis MA, Fernstrom JD. Reduction in brain serotonin synthesis rate in streptozotocin-diabetic rats. Endocrinology. 1981;109:310–312
  20. Molina HA. Efecto de la diabetes tipo l sobre el metabolismo de la serotonina en ratas. Tesis de licenciatura en nutrición y ciencias en los alimentos. México D F Universidad Iberoamericana 1996:29–36
  21. Trulson ME, Jacoby JH, Mackenzie RG. Streptozotocin-induced diabetes reduces brain serotonin synthesis in rats. J Neurochem. 1986;46:1068–1072
  22. Lackovic Z, Salkovic M. Streptozotocin and alloxan produce alterations in rat brain monoamines independently of pancreatic beta cells destruction. Life Sci. 1990;46:49–54
  23. Yang YF, Lin MT. Brain serotonin depletion attenuates diabetogenic effects of streptozotocin. Am J Physiol. 1995;268:E839–844
  24. Manjarrez GG, Herrera MJR, Molina HA, Bueno SS, González RM, Hernández RJ. Alteraciones de la neurotransmisión serotoninérgica cerebral inducida por diabetes mellitus tipo 1. Rev Invest Clin. 1999;51:293–302
  25. Manjarrez GG, Herrera MJR, Bueno SS, González RM, Hernández -RJ. Cambios en la biosı́ntesis de serotonina cerebral en ratas con diabetes mellitus inducida por estreptozotocina. Efecto del tratamiento con insulina. Rev Invest Clin. 2000;52:509–516
  26. Hernandez RJ, Manjarrez GG, Chagoya G. Newborn humans and rats malnourished in utero (Free plasma L-tryptophan, neutral amino acid and brain serotonin synthesis). Brain Res. 1989;488:1–13
  27. Manjarrez GG, Contreras JL, Chagoya G, Hernandez -RJ. Free tryptophan as an indicator of brain serotonin synthesis in infants. Pediatr Neurol. 1998;18:57–62
  28. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus . Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2000;23(Suppl 1):S4–S19
  29. Peat MA, Gibb JW. High-performance liquid chromatography determination of indoleamines, dopamine, and norepinephrine in rat brain with fluorometric detection. Anal Biochem. 1983;128:275–280
  30. Doumas BT, Watson WA, Biggs HG. Albumin standards the measurement of serum albumin with bromocresol green. Clin Chem Acta. 1971;31:87–96
  31. Falholt KB, Lund B, Falholt W. An easy colorimetric micromethod for routine determination of free fatty acids in plasma. Clin Chem Acta. 1973;46:105–111
  32. Bentley R. Glucose oxidase in the enzymes. In:  Boyer PD editors. The enzymes. 7:New York: Academic Press; 1963;p. 567–586
  33. Cole RA, Soeldner JS, Dunn PJ. A rapid method for the determination of glycosylated hemoglobin using high-pressure liquid chromatography. Metabolism. 1978;27:289–301
  34. Einarsson S, Josefsson B, Lagerkvist S. Determination of amino acids with 9-fluronylmethylcholoroformate and reversed-phase high-performance liquid chromatography. J Chromatogr. 1983;282:609–618
  35. Garber ZM. In: Las caracterı́sticas de interacción y de unión del triptofano con la albúmina plasmática en ratas normales y con desnutrición ontogénica. Tesis de licenciatura en nutrición y ciencias en los alimentos. México City: Universidad Iberoamericana; 1993;p. 65–81
  36. Fernstrom JD, Faller DV, Shabshelowitz H. Acute reduction of brain serotonin and 5-HIAA following food consumption (correlation with the ratio of serum tryptophan to the sum of competing neutral amino acids). J Neural Transm. 1975;36:113–121
  37. Glanville NT, Anderson GH. The effect of insulin deficiency, dietary protein intake, and plasma amino acid concentrations on brain amino acid levels in rats. Can J Physiol Pharmacol. 1985;63:487–494
  38. McCall AL, Millington W, Wurtman RI. Metabolic fuel and amino acid transport into the brain experimental diabetes mellitus. Proc Natl Acad Sci USA. 1982;79:5406–5410
  39. Smith SA, Pogson CHI. The metabolism of L-tryptophan by liver cells prepared from adrenalectomized and streptozotocin-diabetic rats. Biochem J. 1981;200:605–609
  40. Sadler E, Weiner M, Buterbaugh GG. Effect of streptozotocin-induced diabetes on tryptophan oxygenase activity and brain tryptophan levels in rats. Res Commun Chem Pathol Pharmacol. 1983;42:37–50
  41. Badawy AAB. The functions and regulation of tryptophan pyrrolase. Life Sci. 1977;21:755–768
  42. Popkin MK, Callies AL, Lentz RD, Colon EA, Sutherland DE. Prevalence of major depression, simple phobia and other psychiatric disorders in patients with long-standing type 1 diabetes mellitus. Arch Gen Psychiatry. 1988;45:64–68
  43. Massol J, Martin P, Puech AJ. Antidepressant effects of tricyclic antidepressants and selective serotonin-uptake blockers in diabetic rats. Diabetes. 1989;38:1161–1164

PII: S0887-8994(02)00462-9

doi: 10.1016/S0887-8994(02)00462-9

Pediatric Neurology
Volume 28, Issue 1 , Pages 20-23 , January 2003

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