Pediatric Neurology
Volume 28, Issue 1 , Pages 48-52 , January 2003

Reduction of seizures with low-dose clonazepam in children with epilepsy

  • Maria G Dahlin, MD, PhD

      Affiliations

    • Department of Pediatrics, Astrid Lindgren Children’s Hospital, Stockholm, Sweden
    • Corresponding Author InformationCommunications should be addressed to: Dr. Dahlin; Neuropediatric Department; Astrid Lindgren Children’s Hospital; Karolinska Hospital; SE-171 76 Stockholm, Sweden.
  • ,
  • Per E Åmark, MD, PhD

      Affiliations

    • Department of Pediatrics, Astrid Lindgren Children’s Hospital, Stockholm, Sweden
  • ,
  • Arne R Nergårdh, MD, PhD

      Affiliations

    • Department of Pediatrics, Astrid Lindgren Children’s Hospital, Stockholm, Sweden
    • Department of Clinical Pharmacology, Karolinska Hospital, Stockholm, Sweden

Received 2 April 2002 ,Accepted 27 June 2002.

References 

  1. Browne TR. Drug therapy. Clonazepam. N Engl J Med 1978:812–6
  2. Tassinari CA, Michelucci R, Riguzzi P, et al.  The use of diazepam and clonazepam in epilepsy. Epilepsia. 1998;39(Suppl 1):S7–14
  3. Ko DY, Rho JM, De Giorgio CM, Sato S. Benzodiazepines. In:  Engel J,  Pedley TA editor. Epilepsy (A comprehensive textbook). Philadelphia: Lippincott-Raven Publishers; 1998;p. 1475–1490
  4. Dreifuss FE, Penry JK, Rose SW, Kupferberg HJ, Dyken P, Sato S. Serum clonazepam concentrations in children with absence seizures. Neurology. 1975;25:255–258
  5. Nanda R, Keogh HD, Lambie D, Johnson RH, Melville ID, Morrice GD. The effects of clonazepam upon epilepsy control and plasma levels of other anticonvulsants. In:  Janz D editors. Epileptology (Proceedings of the Seventh International Symposium on Epilepsy). Stuttgart: Thieme; 1976;p. 145–151
  6. Mikkelsen B, Birket-Smith E, Brandt S, et al.  Clonazepam in the treatment of epilepsy (A controlled clinical trial in simple absences, bilateral massive myoclonus and atonic seizures). Arch Neurol. 1976;33:322–325
  7. Bensch J, Blennow G, Ferngren H, et al.  A double-blind study of clonazepam in the treatment of therapy-resistant epilepsy in children. Dev Med Child Neurol. 1977;19:335–342
  8. Mikkelsen B, Berggreen P, Joensen P, Kristensen O, Kohler O, Mikkelsen BO. Clonazepam (Rivotril) and carbamazepine (Tegretol) in psychomotor epilepsy (A randomized multicenter trial). Epilepsia. 1981;22:415–420
  9. Naito H, Wachi M, Nishida M. Clinical effects and plasma concentrations of long-term clonazepam monotherapy in previously untreated epileptics. Acta Neurol Scand. 1987;76:58–63
  10. Mc Namara JO. Drugs effective in the therapy of the epilepsies. In:  Hardman JG,  Limbird LE editor. Goodman & Gilman’s The pharmacological basis of therapeutics. New York: McGraw-Hill; 1996;p. 461–486
  11. Aicardi J. Medical treatment. In:  Aicardi J editors. Epilepsy in children. 2nd ed. New York: Raven Press; 1992;p. 402–428
  12. Dahlin M, Knutsson E, Amark P, Nergardh A. Reduction of epileptiform activity in response to low-dose clonazepam in children with epilepsy (a randomized, double-blind study). Epilepsia. 2000;41:308–315
  13. Commission on Classification and Terminology of the International League Against Epilepsy . Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia. 1981;22:489–501
  14. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389–99
  15. Rovei V, Sanjuan M. Simple and specific high performance liquid chromatographic method for the routine monitoring of clonazepam in plasma. Ther Drug Monit. 1980;2:283–287
  16. Boukhabza A, Lugnier AA, Kintz P, Mangin P, Chaumont AJ. Simple and sensitive method for monitoring clonazepam in human plasma and urine by high performance liquid chromatography. J Chromatogr. 1990;529:210–216
  17. Painter PC, Cope JY, Smith JL. Reference information for the clinical laboratory. In:  Burtis CA,  Ashwood ER editor. Tietz textbook of clinical chemistry. Philadelphia: WB Saunders Company; 1999;p. 1788–1846
  18. Eadie MJ. Neurological diseases. In:  Speight TM,  Holford NGH editor. Avery’s drug treatment. Auckland: Adis International; 1997;p. 1347–1394
  19. Haslem RHA. The nervous system. In:  Behrman RE,  Kliegman RM,  Jenson HB editor. Nelson textbook of pediatrics. Philadelphia: WB Saunders Company; 2000;p. 1793–1866
  20. Rey E, Tréluyer J, Pons G. Pharmacokinetic optimization of benzodiazepine therapy for acute seizures. Clin Pharmacokinet. 1999;36:409–424
  21. Greenblatt DJ, Miller LG, Shader RI. Clonazepam pharmacokinetics, brain uptake, and receptor interactions. J Clin Psychiatry. 1987;48(Suppl 10):4–9
  22. Montplaisir J, Laverdière M, Saint-Hilaire JM. Sleep and epilepsy. In:  Gotman J,  Ives JR,  Gloor P editor. Long-term monitoring in epilepsy (EEG Suppl. No. 37). Amsterdam: Elsevier Science Publishers; 1985;p. 215–239

PII: S0887-8994(02)00468-X

doi: 10.1016/S0887-8994(02)00468-X

Pediatric Neurology
Volume 28, Issue 1 , Pages 48-52 , January 2003