Pediatric Neurology
Volume 28, Issue 1 , Pages 53-58 , January 2003

Effectiveness of creatine monohydrate in mitochondrial encephalomyopathies

  • Kiyomi Komura, MD

      Affiliations

    • Department of Pediatrics; Tokyo Women’s Medical University; Tokyo, Japan
    • Corresponding Author InformationCommunications should be addressed to: Dr. Komura; Department of Pediatrics; Tokyo Women’s Medical University; 8-1 Kawadacho; Shinjuku-ku; Tokyo 162-8666, Japan.
    • ,
  • Elke Hobbiebrunken, MD

      Affiliations

    • Abteilung Kinderheilkunde; Schwerpunkt Neuropädiatrie; Georg-August-Universität, Göttingen, Germany
    • ,
  • Ekkehard K.G Wilichowski, MD

      Affiliations

    • Abteilung Kinderheilkunde; Schwerpunkt Neuropädiatrie; Georg-August-Universität, Göttingen, Germany
    • ,
  • Folker A Hanefeld, MD

      Affiliations

    • Abteilung Kinderheilkunde; Schwerpunkt Neuropädiatrie; Georg-August-Universität, Göttingen, Germany

Received 2 April 2002 ,Accepted 27 June 2002.

References 

  1. Borchert A, Wilichowski E, Hanefeld F. Supplementation with creatine monohydrate in children with mitochondrial encephalomyopathies. Muscle Nerve. 1999;22:1299–1300
  2. Dubowitz V. The procedure of muscle biopsy. In:  Dubowitz V editors. Muscle biopsy: A practical approach. 2nd ed. London: Bailliere Tindall; 1985;p. 3–18
  3. Dubowitz V. Histological and histochemical stains and reactions. In:  Dubowitz V editors. Muscle biopsy: A practical approach. 2nd ed. London: Bailliere Tindall; 1985;p. 19–40
  4. Engelhardt M, Neumann G, Berbalk A, Reuter I. Creatine supplementation in endurance sports. Med Sci Sports Exerc. 1998;30:1123–1129
  5. Gordon A, Hultman E, Kaijser L, et al.  Creatine supplementation in chronic heart failure increases skeletal muscle creatine phosphate and muscle performance. Cardiovasc Res. 1995;30:413–418
  6. Hagenheldt L, von Dodeln U, Solders G, Kaijser L. Creatine treatment in MELAS (letter). Muscle Nerve. 1994;17:1236–1237
  7. Hobbiebrunken E, Wüstenfeld H, Modler H, Böhm R, Hanefeld F. Das Göttinger-Kinderfahrradergometer-Kraft und Ausdauer Messung bei gesunden und muskelkranken Kindern. Med Genetik. 1997;9:461
  8. Johns DR. Mitchondrial DNA and disease. N Engl J Med. 1995;333:638–644
  9. Persky AM, Brazeau GA. Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacol Rev. 2001;53:161–176
  10. Przyrembel H. Therapy of mitochondrial disorders. J Inher Metab Dis. 1987;10:129–146
  11. Stöckler S, Hanefeld F, Frahm J. Creatine replacement therapy in a guanidinoacetate methyltransferase deficiency, a novel inborn error of metabolism. Lancet. 1996;348:789–790
  12. Tarnopolsky MA, Parise G. Direct measurement of high-energy phosphate compounds in patients with neuromuscular disease. Muscle Nerve. 1999;22:1228–1233
  13. Tarnopolsky MA, Parshad A, Walzel B, Schlattner U, Wallimann T. Creatine transporter and mitochondrial creatine kinase protein content in myopathies. Muscle Nerve. 2001;24:682–688
  14. Tarnopolsky MA, Roy BD, Donald JR. A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve. 1997;20:1502–1509
  15. Vannas-Sulonen K, Sipila I, Vannas A, Simell O, Rapola J. Gyrate atrophy of the choroid and retina. A five-year follow-up of creatine supplementation. Ophthalmology. 1985;92:1719–1727
  16. Wallimann T, Wyss M, Brdiczka D, Nicolay K. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands (the ‘phosphocreatine circuit’ for cellular energy homeostasts). Biochem J. 1992;281:21–40
  17. Walsh B, Tonkonogi M, Soderlund K, Hultman E, Saks V, Sahlin K. The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle. J Physiol. 2001;15(537 Pt 3):971–978
  18. Williams MH, Branch JD. Creatine supplementation and exercise performance (An update). J Am Coll Nutr. 1998;17:216–234

PII: S0887-8994(02)00469-1

doi: 10.1016/S0887-8994(02)00469-1

Pediatric Neurology
Volume 28, Issue 1 , Pages 53-58 , January 2003

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