Pediatric Neurology
Volume 28, Issue 2 , Pages 151-155 , February 2003

Transient nonketotic hyperglycinemia: two case reports and literature review

  • Didem Aliefendioğlu, MD

      Affiliations

    • Social Security Children’s Hospital, Neonatology Unit, Ankara, Turkey
    • Corresponding Author InformationCommunications should be addressed to: Dr. Aliefendioğlu; Çiğdem Mahallesi Park Sitesi 46/15; 06530 Balgat Ankara, Turkey.
    • ,
  • A.yşe Tana Aslan, MD

      Affiliations

    • Social Security Children’s Hospital, Neonatology Unit, Ankara, Turkey
    • ,
  • Turgay Coşkun, MD

      Affiliations

    • Department of Pediatrics, Metabolism and Nutrition Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey
    • ,
  • Ali Dursun, MD

      Affiliations

    • Department of Pediatrics, Metabolism and Nutrition Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey
    • ,
  • Fatma Nur Çakmak, MD

      Affiliations

    • Department of Pediatrics, Metabolism and Nutrition Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey
    • ,
  • Mehmet Kesimer, PhD

      Affiliations

    • Department of Pediatrics, Metabolism and Nutrition Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey

Received 13 May 2002 ,Accepted 21 August 2002.

References 

  1. Tada K. Nonketotic hyperglycinemia (Clinical and metabolic aspects). Enzyme. 1987;38:27–35
  2. Lu FL, Wang P-J, Hwu WL, Tsou Yau K-I, Wang T-R. Neonatal type of nonketotic hyperglycinemia (Case report). Pediatr Neurol. 1999;20:295–300
  3. Hayasaka K, Tada K, Fueki N, Nakamura Y, Nyhan WL, Schmidt K. Non-ketotic hyperglycinemia (Analyses of glycine system in typical and atypical cases). J Pediatr. 1987;110:873–877
  4. Tada K, Hayasaka K. Nonketotic hyperglycinemia (Clinical and biochemical aspects). Eur J Pediatr. 1987;146:221–227
  5. Tada K, Kure S, Takayanagi M, Kume A, Nrisawa K. Nonketotic hyperglycinemia (A life threatening disorder in the neonate). Early Human Development. 1992;29:75–81
  6. Volpe JJ. Bilirubin and brain injury. In: Neurology of the newborn, 2nd ed. Philadelphia: WB Saunders, 1987:386-408
  7. DiMauro S, Nicolson JF, Hays AP, et al.  Benign infantile mitochondrial myopathy due to reversible cytochrome c oxydase deficiency. Ann Neurol. 1983;14:226–234
  8. Maeda T, Inutsuka M, Goto K, Izumi T. Transient nonketotic hyperglycinemia in an asphyxiated patient with pyridoxine-dependent seizures. Pediatr Neurol. 2000;22:225–227
  9. Luder AS, Davidson A, Goodman SI, Greene CL. Transient nonketotic hyperglycinemia in neonates. J Pediatr. 1989;114:1013–1015
  10. Schiffmann R, Kaye EM, Willis JK, Africk D, Ampola M. Transient neonatal hyperglycinemia. Ann Neurol. 1989;25:201–203
  11. Eyskens FJM, Van Doorn JWD, Marien P. Neurologic sequelae in transient nonketotic hyperglycinemia of the neonate. J Pediatr. 1992;121:620–621
  12. Zammarchi E, Donati MA, Ciani F. Transient neonatal nonketotic hyperglycinemia of the neonate (A 13 year follow-up). Neuropediatrics. 1995;26:328
  13. Hayasaka S, Setogawa T, Hara S, Ishizawa S, Hayasaka K, Tada K. Nystagmus and subnormal electroretinographic response in nonketotic hyperglycinemia. Graefe’s Arch Clin Exp Ophthalmol. 1987;225:277–278
  14. Gerner EW, Hughes SM. Floppy eyelid with hyperglycinemia. Am J Opthalmol. 1984;98:614–616
  15. Paciuc M, Mier ME. A woman with the floppy eyelid syndrome. Am J Opthalmol. 1982;93:255–256
  16. Schiffmann R, Boneh A, Ergaz Z, Glick B. Nonketotic hyperglycinemia presenting with pinpoint pupils and hyperammonemia. Israel J Med Sci. 1992;28:91–93
  17. Plum F, Posner JB. The pathologic physiology of signs and symptoms of coma: The diagnosis of stupor and coma, 3rd ed. Philadelphia: Davis Company, 1980

PII: S0887-8994(02)00501-5

doi: 10.1016/S0887-8994(02)00501-5

Pediatric Neurology
Volume 28, Issue 2 , Pages 151-155 , February 2003

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