Pediatric Neurology
Volume 28, Issue 3 , Pages 184-189 , March 2003

Oligohydrosis and fever in pediatric patients treated with zonisamide

  • James F. Knudsen, PhD, MD

      Affiliations

    • Center for Drug Evaluation and Research, Division of Neuropharmacological Drug Products, Rockville, Maryland, USA
    • Corresponding Author InformationCommunications should be addressed to: Dr. Knudsen; Food and Drug Administration; Center for Drug Evaluation and Research; Division of Neuropharmacological Drug Products; 5600 Fishers Lane, HFD-120; Rockville, MD, USA20857
    • ,
  • Lopa R. Thambi, PharmD

      Affiliations

    • Center for Drug Evaluation and Research, Division of Neuropharmacological Drug Products, Rockville, Maryland, USA
    • ,
  • Leonard P. Kapcala, MD

      Affiliations

    • Center for Drug Evaluation and Research, Office of Drug Safety, Food and Drug Administration, Rockville, Maryland, USA
    • ,
  • Judith A. Racoosin, MD, MPH

      Affiliations

    • Center for Drug Evaluation and Research, Division of Neuropharmacological Drug Products, Rockville, Maryland, USA

Received 6 June 2002 ,Accepted 21 August 2002.

References 

  1. Masereel B, Rolin S, Abbate F, Scozzafava Asupuran CT. Carbonic anhydrase inhibitors (anticonvulsant sulfonamides incorporating valproyl and lipophilic moieties). J Med Chem. 2002;45:312–320
  2. Nakatsuji K, Matsuno N, Nakamura N, Fujitani B, Ito T, Kadokawa T. General pharmacology of the novel antiepileptic compound zonisamide. Arzneim Forsch. 1987;37:1131–1136
  3. Maren TH. Carbonic anhydrase (Chemistry, physiology and inhibition). Physiol Rev. 1967;47:595–781
  4. Swenson ER. Respiratory and renal roles of carbonic anhydrase in gas exchange and acid-base regulation. In:  Chegwidden WR,  Carter ND,  Edwards TH editor. The carbonic anhydrase new horizons. Basal: Birkhäuser Verlag; 2000;p. 281–341
  5. Okumura A, Hayakawa F, Kuno K, Watanabe K. Oligohydrosis caused by zonisamide. No To Hattatsu. 1996;28:44–47
  6. Shimizu Y, Togo A, Eto M, et al.  Oligohydrosis induced by zonisamide, clinical features of 7 cases and skin histology. J Japan Ped Society. 1996;100:350–351
  7. Hosada N, Miura T, Takanashi S, Shirai H, Sunaoshi W, Takei K, Clinical experience of dyshidrosis induced by zonisamide. Kanagawa Seishin Igaku Kaishi. 1996;46:121
  8. Hosada N, Miura H, Shirai H, Sunaoshi W, Takei K. Dyshidrosis by zonisamide. Japanese J Ped. 1996;49(11):2445–2449
  9. Brinker A, Beitz J. Use of a spontaneous adverse drug events database for identification of unanticipated drug benefits. Clin Pharmacol Ther. 2002;71:99–102
  10. Rodriguez EM, Staffa JA, Graham DJ. The role of databases in drug postmarketing surveillance. Pharmacoepidemiol Drug Saf. 2001;10:407–410
  11. Arcas J, Ferrer T, Roche M, Bermejo-Martinez A, Lopez-Martin V. Hypohidrosis related to the administration of topiramate to children. Epilepsia. 2001;42:1363–1365
  12. Walsh P. Product information (zonisamide). In: Physicians’ Desk Reference. Montvale, NJ: Medical Economics Co; 2002:1307–11
  13. LaGrenade L, Graham D, Nourjah P. Underreporting of hemorrhagic stroke associated with phenylpropanolamine. Letter to the Editor, JAMA. 2001;286:3081
  14. Tanaka K, Matsuoka O, Hattori H, Hattori K. Seto T, Murata R (Dyshidrosis caused by zonisamide). The Osaka Journal of Epilepsy Research. 1997;8:31–34
  15. McJilton J, ReToledo J, DeCerce J, Huda S, Abubakr A, Ramsay R. Cotherapy of lamotrigine/zonisamide results in significant elevation of zonisamide levels. Epilepsia. 1996;37(suppl 5):173
  16. Rudolf A, Hoffman J, Rudolf C, eds. Rudolph’s Pediatrics 20th ed. Stamford, CT: Appleton and Lange, 1996:1321–2
  17. Fujita Y, Okubo O, Noguchi Y, et al.  A study of zonisamide-induced hidropoietic disorder. No To Hattatsu. 1995;27(suppl):S187
  18. Otani K, Yanagihara K, Imai K. Zonisamide and oligohydrosis. No To Hattatsu. 1995;27(Suppl):S127
  19. Okumura A, Ishihara N, Kato T, Hayakawa F, Kuno K, Watanabe K. Predictive value of acetylcholine stimulation testing for oligohydrosis caused by zonisamide. Pediatr Neurol. 2000;23:59–61
  20. Ono M, Inagaki Y, Ono M, Ueki H. Localization of carbonic anhydrase I and II in the normal human skin. J Dermatol Sci. 1996;12:201–206
  21. Dahlborn K, Jansson A, Nyman S, Morgan K, Holm L, Ridderstrale Y. Sweat production and localization of carbonic anhydrase in the equine sweat gland during exercise. Equine Vet J. 1999;30:398–403
  22. Sato K, Kang W, Sato F. Eccrine sweat glands. In:  Goldsmith LA editors. Physiology, Biochemistry and Molecular Biology of the Skin. 2nd edition. New York: Oxford University Press; 1991;p. 741–761

PII: S0887-8994(02)00511-8

doi: 10.1016/S0887-8994(02)00511-8

Pediatric Neurology
Volume 28, Issue 3 , Pages 184-189 , March 2003

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