Pediatric Neurology
Volume 28, Issue 5 , Pages 396-399 , May 2003

Influenza B acute necrotizing encephalopathy: a case report and literature review

  • Mona Sazgar, BSc, MD

      Affiliations

    • Department of Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada
    • Division of Neurology, University of Alberta Hospital, Edmonton, Alberta, Canada
    • ,
  • Joan L Robinson, MD

      Affiliations

    • Department of Pediatrics, University of Alberta Hospital, Edmonton, Alberta, Canada
    • Division of Pediatric Neurology, University of Alberta Hospital, Edmonton, Alberta, Canada
    • ,
  • Alicia K.J Chan, MD

      Affiliations

    • Division of Pediatric Neurology, University of Alberta Hospital, Edmonton, Alberta, Canada
    • Department of Medical Genetics; University of Alberta Hospital, Edmonton, Alberta, Canada
    • ,
  • D.Barry Sinclair, MD

      Affiliations

    • Department of Pediatrics, University of Alberta Hospital, Edmonton, Alberta, Canada
    • Division of Pediatric Neurology, University of Alberta Hospital, Edmonton, Alberta, Canada
    • Corresponding Author InformationCommunications should be addressed to:Dr. Sinclair; Division of Pediatric Neurology, Department of Pediatrics, University of Alberta Hospital; 2C3 Walter C Mackenzie Health Sciences Centre; 8440 112 Street; Edmonton AB;Canada T6G 2B7.

Received 27 August 2002 ,Accepted 10 December 2002.

References 

  1. Mizuguchi M, Abe J, Mikkaichi K, et al.  Acute necrotizing encephalopathy of childhood (A new syndrome presenting with multifocal, symmetric brain lesions). J Neurol Neurosurg Psychiatry. 1995;58:555–561
  2. Mizuguchi M. Acute necrotizing encephalopathy of childhood (A novel form of acute encephalopathy prevalent in Japan and Taiwan). Brain Dev. 1997;19:81–92
  3. Protheroe SM, Mellor DH. Imaging in influenza A encephalitis. Arch Dis Child. 1991;66:702–705
  4. Campistol J, Gassio R, Pineda M, Fernandez-Alvarez E. Acute necrotizing encephalopathy of childhood (infantile bilateral thalamic necrosis) (Two non-Japanese cases). Dev Med Child Neurol. 1998;40:771–774
  5. Charney EB, Orecchio EJ, Zimmerman RA, Berman PH. Computerized tomography in infantile encephalitis. Am J Dis Child. 1979;133:803–805
  6. Ravid S, Topper L, Eviatar L. Acute necrotizing encephalopathy presenting as a basal ganglia syndrome. J Child Neurol. 2001;16:461–462
  7. Matsushita E, Takita K, Shimada A. Suspected acute encephalopathy with symmetrical abnormal signal areas in the basal ganglia, thalamus, midbrain and pons diagnosed by magnetic resonance imaging. Acta Paediatr Japan. 1997;39:454–458
  8. Shinjoh M, Bamba M, Jozaki K, Takahashi E, Koniuma G, Sugaya N. Influenza A associated encephalopathy with bilateral thalamic necrosis in Japan. Clin Infect Dis. 2000;31:611–613
  9. McCullers JA, Facchini S, Chesney PJ, Webster RG. Influenza B virus encephalitis. Clin Infect Dis. 1999;28:898–900
  10. Sugaya N, Yoshikawa T, Miura M, Ishizuka T, Kawakami C, Asano Y. Influenza encephalopathy associated with infection with human herpesvirus 6 and/or human herpesvirus 7. Clin Infect Dis. 2002;34:461–466
  11. Tran TD, Kubota M, Takeshita K, Yanagisawa M, Sakakihara Y. Varicella associated acute necrotizing encephalopathy with a good prognosis. Brain Dev. 2001;23:54–57
  12. Sugaya N. Influenza-associated encephalopathy in Japan (Pathogenesis and treatment). Pediatr Int. 2000;42:215–218
  13. Aiba H, Mochizuki M, Kimura M, Hojo H. Predictive value of serum interleukin-6 level in influenza virus-associated encephalopathy. Neurology. 2001;57:295–299
  14. Munkata M, Kato R, Yokoyama H, et al.  Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy. Brain Dev. 2000;22:373–377
  15. Yokota S, Imagawa T, Miyamae T, et al.  Hypothetical pathophysiology of acute encephalopathy and encephalitis related to influenza virus infection and hypothermia therapy. Pediatr Int. 2000;42:197–203
  16. Wang HS, Huang SC. Acute necrotizing encephalopathy of childhood. Chang Gung Med J. 2001;24:1–10

PII: S0887-8994(03)00008-0

doi: 10.1016/S0887-8994(03)00008-0

Pediatric Neurology
Volume 28, Issue 5 , Pages 396-399 , May 2003

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