Pediatric Neurology
Volume 28, Issue 4 , Pages 300-303 , April 2003

Rapid infusion of sodium valproate in acutely ill children

  • Angela K Birnbaum, PhD

      Affiliations

    • Experimental & Clinical Pharmacology, Epilepsy Research and Education Program, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA
    • Corresponding Author InformationCommunications should be addressed to: Dr. Birnbaum; University of Minnesota; Experimental & Clinical Pharmacology; College of Pharmacy; 7-170 WDH; 308 Harvard St. S.E.; Minneapolis, MN 55455, USA.
    • ,
  • Robert L Kriel, MD

      Affiliations

    • Experimental & Clinical Pharmacology, Epilepsy Research and Education Program, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA
    • Departments of Pediatrics and Neurology, Hennepin County Medical Center, Minneapolis, Minnesota, USA
    • Gillette Children’s Specialty Healthcare, St. Paul, Minnesota, USA
    • ,
  • Shani K Norberg, MD

      Affiliations

    • Gillette Children’s Specialty Healthcare, St. Paul, Minnesota, USA
    • ,
  • Beverly S Wical, MD

      Affiliations

    • Gillette Children’s Specialty Healthcare, St. Paul, Minnesota, USA
    • ,
  • Duy N Le, PharmD

      Affiliations

    • Experimental & Clinical Pharmacology, Epilepsy Research and Education Program, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Ilo E Leppik, MD

      Affiliations

    • Experimental & Clinical Pharmacology, Epilepsy Research and Education Program, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA
    • MINCEP® Epilepsy Care, St. Louis Park, Minnesota, USAPreliminary data was presented in the form of an abstract/poster at the annual American Epilepsy Society in December 1999.
    • ,
  • James C Cloyd, PharmD

      Affiliations

    • Experimental & Clinical Pharmacology, Epilepsy Research and Education Program, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA

Received 15 August 2002 ,Accepted 25 November 2002.

References 

  1. Hovinga CA, Chicella MF, Rose DF, Eades SK, Dalton JT, Phelps SJ. Use of intravenous valproate in three pediatric patients with nonconvulsive or convulsive status epilepticus. Ann Pharmacother. 1999;33:579–584
  2. Uberall MA, Trollmann R, Wunsiedler U, Wenzel D. Intravenous valproate in pediatric epilepsy patients with refractory status epilepticus. Neurology. 2000;54:2188–2189
  3. Limdi NA, Faught E. The safety of rapid valproic acid infusion. Epilepsia. 2000;41:1342–1345
  4. Venkataraman V, Wheless JW. Safety of rapid intravenous infusion of valproate loading doses in epilepsy patients. Epilepsy Res. 1999;35:147–153
  5. Cloyd JC, Dutta S, Cao G, Walch JK, Collins SD, Granneman RG. The Depacon Study Group. Valproate unbound fraction and distribution volume following rapid infusions in patients with epilepsy. Epilepsy Res 2003;53:19-27
  6. Giroud M, Gras D, Escousse A, Dumas R, Venaud G. Use of injectable valproic acid in status epipepticus (A pilot study). Drug Investi. 1993;5:154–159
  7. Moore AJ, Bell BA, Berry JD. Intravenous sodium valproate in neurosurgery: repeat dose pharmacokinetic study and safety assessment in neurosurgical patients. In: Chadwick D, ed. Fourth international symposium on sodium valproate and epilepsy. Royal Society of Medicine Services Limited; London 1989, pg 204-207
  8. Jolley ME. Fluorescence polarization immunoassay for determination of therapeutic drug levels in human plasma. J Anal Toxicol. 1981;5:236–240
  9. Jolley ME, Stroupe SD, Schwenzer KS, et al.  Fluorescence polarization immunoassay III. An automated system for therapeutic drug determination. Clin Chem. 1981;27:1575–1579
  10. Bauer LA, Davis R, Wilensky A, Raisys V, Levy RH. Valproic acid clearance (Unbound fraction and diurnal variation in young and elderly adults). Clin Pharmacol Ther. 1985;37:697–700
  11. Riva R, Albani F, Franzoni E, Perucca E, Santucci M, Baruzzi A. Valproic acid free fraction in epileptic children under chronic monotherapy. Ther Drug Monit. 1983;5:197–200
  12. Lenn NJ, Robertson M. Clinical utility of unbound antiepileptic drug blood levels in the management of epilepsy. Neurology. 1992;42:988–990
  13. Svensson CK, Woodruff MN, Baxter JG, Lalka D. Free drug concentration monitoring in clinical practice. Rationale and current status. Clin Pharmacokinet. 1986;11:450–469

PII: S0887-8994(03)00019-5

doi: 10.1016/S0887-8994(03)00019-5

Pediatric Neurology
Volume 28, Issue 4 , Pages 300-303 , April 2003

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