Pediatric Neurology
Volume 29, Issue 2 , Pages 160-163, August 2003

A patient with epilepsia partialis continua with anti-glutamate receptor ε2 antibodies

  • Akira Kumakura, MD

      Affiliations

    • Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, Japan
    • ,
  • Tomoko Miyajima, MD

      Affiliations

    • Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, Japan
    • ,
  • Tatsuya Fujii, MD, PhD

      Affiliations

    • Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, Japan
    • ,
  • Yukitoshi Takahashi, MD, PhD

      Affiliations

    • National Epilepsy Center, Shizuoka MIND, 886 Urushiyama, Shizuoka 420-8688, Japan
    • ,
  • Masatoshi Ito, MD, PhD

      Affiliations

    • Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, Japan
    • Corresponding Author InformationCommunications should be addressed to: Dr. Ito; Department of Pediatrics; Shiga Medical Center for Children; 5-7-30 Moriyama; Moriyama, Shiga 524-0022, Japan.

Received 7 November 2002; accepted 17 February 2003.

Abstract 

This report concerns a 6-year-old female with epilepsia partialis continua. Autoantibodies against amino- and carboxyl-terminal regions of the N-methyl-d-aspartate receptor subunit glutamate receptor ε2 were detected in the serum and cerebrospinal fluid. The anti-glutamate receptor ε2 subunit antibodies have been demonstrated in the serum and cerebrospinal fluid in some patients with chronic progressive epilepsia partialis continua of childhood and those with Rasmussen’s encephalitis. The patient, however, did not develop any neurologic deterioration or intractable seizures. Therefore, anti-glutamate receptor ε2 subunit antibodies are not specific for chronic progressive epilepsia partialis continua of childhood and Rasmussen’s encephalitis.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0887-8994(03)00151-6

doi:10.1016/S0887-8994(03)00151-6

Pediatric Neurology
Volume 29, Issue 2 , Pages 160-163, August 2003

Article Tools