Pediatric Neurology
Volume 29, Issue 2 , Pages 160-163 , August 2003

A patient with epilepsia partialis continua with anti-glutamate receptor ε2 antibodies

  • Akira Kumakura, MD

      Affiliations

    • Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, Japan
    • ,
  • Tomoko Miyajima, MD

      Affiliations

    • Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, Japan
    • ,
  • Tatsuya Fujii, MD, PhD

      Affiliations

    • Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, Japan
    • ,
  • Yukitoshi Takahashi, MD, PhD

      Affiliations

    • National Epilepsy Center, Shizuoka MIND, 886 Urushiyama, Shizuoka 420-8688, Japan
    • ,
  • Masatoshi Ito, MD, PhD

      Affiliations

    • Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, Japan
    • Corresponding Author InformationCommunications should be addressed to: Dr. Ito; Department of Pediatrics; Shiga Medical Center for Children; 5-7-30 Moriyama; Moriyama, Shiga 524-0022, Japan.

Received 7 November 2002 ,Accepted 17 February 2003.

References 

  1. Rogers SW, Andrews PI, Gahring LC, et al.  Autoantibodies to glutamate receptor GluR3 in Rasmussen’s encephalitis. Science. 1994;265:648–651
  2. Andrews PI, Dichter MA, Berkovic SF, et al.  Plasmapheresis in Rasmussen’s encephalitis. Neurology. 1996;46:242–246
  3. Takahashi Y, Sakaguchi N, Kondo N, et al.  Early diagnosis and transient for intractable epileptic patients with auto-antibodies against glutamate receptor. Ann Rep Jap Epi Res Found. 1999;11:45–52 [in Japanese]
  4. Wiendl H, Bien CG, Bernasconi P, et al.  GluR3 antibodies (Prevalence in focal epilepsy but no specificity for Rasmussen’s encephalitis). Neurology. 2001;57:1511–1514
  5. Gossen M, Freundlieb S, Bender G, et al.  Transcriptional activation by tetracyclines in mammalian cells. Science. 1995;268:1766–1769
  6. Takahashi Y, Sakaguchi N, Kondo N, et al.  Auto-antibodies against glutamate receptor ε2 in patients with chronic progressive epilepsia partialis continua of childhood. Epilepsia. 2001;42(Suppl. 6):47–48
  7. Takahashi Y, Sakaguchi N, Kondo N, et al.  Epitope analysis of auto-antibodies against GluR ε2 in patients with chronic progressive epilepsia partialis continua of childhood. Epilepsia. 2002;43(Suppl. 9):74
  8. Mishima M. In: Molecular diversity, structure, and function of glutamate receptor channels (Handbook of experimental pharmacology). Berlin: Springer-Verlag; 2000;p. 392–414
  9. Mori H, Manabe T, Watanabe M, et al.  Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel. Neuron. 1998;21:571–580
  10. Sattler R, Tymianski M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol Neurobiol. 2001;24:107–129
  11. Bancaud J. Kojewnikow’s syndrome (epilepsia partialis continua) in children. In:  Roger J,  Bureau M,  Dravet CH,  Dreifuss FE,  Perret A,  Wolf P editor. Epileptic syndromes in infancy, childhood and adolescence. 2nd ed. London: John Libbey; 1992;p. 363–379
  12. Watson R, Lang B, Bermudez I, et al.  Autoantibodies in Rasmussen’s encephalitis. J Neuroimmunol. 2001;118:148
  13. Yang R, Puranam RS, Butler LS, et al.  Autoimmunity to munc-18 in Rasmussen’s encephalitis. Neuron. 2000;28:375–383

PII: S0887-8994(03)00151-6

doi: 10.1016/S0887-8994(03)00151-6

Pediatric Neurology
Volume 29, Issue 2 , Pages 160-163 , August 2003

Article Tools