Pediatric Neurology
Volume 29, Issue 3 , Pages 218-221, September 2003

Neuroprotective effects of early antiretrovirals in vertical HIV infection

  • Silvia Sánchez-Ramón, MD

      Affiliations

    • Unit of Neuroimmunology, Laboratory of Immuno-Molecular Biology, Madrid, Spain
    • ,
  • Salvador Resino, PhD

      Affiliations

    • Unit of Neuroimmunology, Laboratory of Immuno-Molecular Biology, Madrid, Spain
    • ,
  • José M Bellón Cano, MsC

      Affiliations

    • Unit of Neuroimmunology, Laboratory of Immuno-Molecular Biology, Madrid, Spain
    • ,
  • José T Ramos, MD

      Affiliations

    • Department of Paediatrics, and Hospital Doce de Octubre, Madrid, Spain
    • ,
  • Dolores Gurbindo, MD

      Affiliations

    • Unit of Immunopaediatrics, Hospital General Universitario Gregorio Marañón, Madrid, Spain
    • ,
  • Angeles Muñoz-Fernández, PhD, MD

      Affiliations

    • Unit of Neuroimmunology, Laboratory of Immuno-Molecular Biology, Madrid, Spain
    • Corresponding Author InformationCommunications should be addressed to: Dr. Muñoz-Fernández; Laboratory of Immuno-Molecular Biology; Hospital General Universitario “Gregorio Marañón”; C/Doctor Esquerdo 46, 28007; Madrid, Spain.

Received 17 October 2002; accepted 3 March 2003.

Abstract 

We performed a retrospective study of a series of 58 of 189 vertically HIV-1 infected children who went on to develop progressive HIV-1-associated encephalopathy to assess real-life effects of early antiretroviral therapy on neurologic outcome. Our findings clearly indicate that antiretroviral therapy before the onset of neurologic symptoms delayed presentation of progressive HIV-1-associated encephalopathy, with an additional beneficial effect on survival.

Keywords:  CNS, HIV-1-related encephalopathy, development, pediatric AIDS, survival, viral load

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PII: S0887-8994(03)00210-8

doi:10.1016/S0887-8994(03)00210-8

Pediatric Neurology
Volume 29, Issue 3 , Pages 218-221, September 2003

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