Pediatric Neurology
Volume 29, Issue 3 , Pages 218-221 , September 2003

Neuroprotective effects of early antiretrovirals in vertical HIV infection

  • Silvia Sánchez-Ramón, MD

      Affiliations

    • Unit of Neuroimmunology, Laboratory of Immuno-Molecular Biology, Madrid, Spain
    • ,
  • Salvador Resino, PhD

      Affiliations

    • Unit of Neuroimmunology, Laboratory of Immuno-Molecular Biology, Madrid, Spain
    • ,
  • José M Bellón Cano, MsC

      Affiliations

    • Unit of Neuroimmunology, Laboratory of Immuno-Molecular Biology, Madrid, Spain
    • ,
  • José T Ramos, MD

      Affiliations

    • Department of Paediatrics, and Hospital Doce de Octubre, Madrid, Spain
    • ,
  • Dolores Gurbindo, MD

      Affiliations

    • Unit of Immunopaediatrics, Hospital General Universitario Gregorio Marañón, Madrid, Spain
    • ,
  • Angeles Muñoz-Fernández, PhD, MD

      Affiliations

    • Unit of Neuroimmunology, Laboratory of Immuno-Molecular Biology, Madrid, Spain
    • Corresponding Author InformationCommunications should be addressed to: Dr. Muñoz-Fernández; Laboratory of Immuno-Molecular Biology; Hospital General Universitario “Gregorio Marañón”; C/Doctor Esquerdo 46, 28007; Madrid, Spain.

Received 17 October 2002 ,Accepted 3 March 2003.

References 

  1. Price RW, Yiannoutsos CT, Clifford DB, et al.  Neurological outcomes in late HIV infection (Adverse impact of neurological impairment on survival and protective effect of antiviral therapy). AIDS. 1999;13:1677–1685
  2. Cooper ER, Hanson C, Diaz C, et al.  Encephalopathy and progression of human immunodeficiency virus disease in a cohort of children with perinatally acquired human immunodeficiency virus infection. J Pediatr. 1998;132:808–812
  3. Lobato MN, Caldwell MB, Ng P, Oxtoby MJ. Encephalopathy in children with perinatally acquired human immunodeficiency virus infection. J Pediatr. 1995;126:710–715
  4. McArthur JC, Hoover DR, Bacellar H, et al.  Dementia in AIDS patients (Incidence and risk factors. Multicenter AIDS Cohort Study). Neurology. 1993;43:2245–2252
  5. Sacktor NC, Lyles RH, Skolasky RL, et al.  Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men. Multicenter AIDS Cohort Study (MACS). Neurology. 1999;52:1640–1647
  6. McKinney RE, Maha MA, Connor EM, et al.  A multicenter trial of oral zidovudine in children with advanced human immunodeficiency virus disease. N Engl J Med. 1991;324:1018–1025
  7. Raskino C, Pearson DA, Baker CJ, et al.  Neurologic, neurocognitive, and brain growth outcomes in human immunodeficiency virus-infected children receiving different nucleoside antiretroviral regimens. Pediatric AIDS Clinical Trials Group 152 Study Team. Pediatrics. 1999;104:e32
  8. Munoz-Fernandez MA, Obregon E, Navarro J, et al.  Relationship of virologic, immunologic, and clinical parameters in infants with vertically acquired human immunodeficiency virus type 1 infection. Pediatr Res. 1996;40:597–602
  9. Centers for Disease Control and Prevention . 1994 revised guidelines for the performance of CD4+ T-cell determinations in persons with human immunodeficiency virus (HIV) infections. MMWR Recomm Rep. 1994;43:1–21
  10. American Academy of Neurology AIDS Task Force . Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection. Report of a Working Group of the American Academy of Neurology AIDS Task Force. Neurology. 1991;41:778–785
  11. European Collaborative Study . HIV-infected pregnant women and vertical transmission in Europe since 1986. AIDS. 2001;15:761–770
  12. Tardieu M, Le Chenadec J, Persoz A, Meyer L, Blanche S, Mayaux MJ. HIV-1-related encephalopathy in infants compared with children and adults. French Pediatric HIV Infection Study and the SEROCO Group. Neurology. 2000;54:1089–1095
  13. Butler KM, Husson RN, Balis FM, et al.  Dideoxyinosine in children with symptomatic human immunodeficiency virus infection. N Engl J Med. 1991;324:137–144
  14. Pizzo PA, Eddy J, Falloon J, et al.  Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection. N Engl J Med. 1988;319:889–896
  15. Sánchez-Ramón S, Bellón JM, Resino S, et al.  Low CD8+ T-cells may trigger CNS spread of HIV-1-activated monocytes in HIV-1-associated progressive encephalopathy in children. Pediatrics. 2003;111:168–175

PII: S0887-8994(03)00210-8

doi: 10.1016/S0887-8994(03)00210-8

Pediatric Neurology
Volume 29, Issue 3 , Pages 218-221 , September 2003

Article Tools

* Image Usage & Resolution