Pediatric Neurology
Volume 29, Issue 4 , Pages 278-283 , October 2003

Nucleated red blood cell counts: not associated with brain injury or outcome

  • Shannon E.G Hamrick, MD

      Affiliations

    • Departments of Pediatrics, San Francisco, California, USA
    • Corresponding Author InformationCommunications should be addressed to: Dr. Partridge; Clinical Professor of Pediatrics; San Francisco General Hospital; Mail Stop 6E; 1001 Potrero Avenue; San Francisco, CA 94110, USA.
  • ,
  • Steven P Miller, MD

      Affiliations

    • Neurology, San Francisco, California, USA
  • ,
  • Nancy R Newton, MS, RN

      Affiliations

    • Departments of Pediatrics, San Francisco, California, USA
  • ,
  • Julian T Parer, MD, PhD

      Affiliations

    • Obstetrics/Gynecology, San Francisco, California, USA
  • ,
  • Donna M Ferriero, MD

      Affiliations

    • Departments of Pediatrics, San Francisco, California, USA
    • Neurology, San Francisco, California, USA
  • ,
  • A.James Barkovich, MD

      Affiliations

    • Departments of Pediatrics, San Francisco, California, USA
    • Neurology, San Francisco, California, USA
    • Radiology, University of California, San Francisco, San Francisco, California., USA
  • ,
  • J.Colin Partridge, MD

      Affiliations

    • Departments of Pediatrics, San Francisco, California, USA

Received 18 November 2002 ,Accepted 29 April 2003.

References 

  1. Low JA. Intrapartum fetal asphyxia (Definition, diagnosis, and classification). Am J Obstet Gynecol. 1997;176:957–959
  2. Volpe JJ. Hypoxic-Ischemic encephalopathy. In: Volpe JJ, ed. Neurology of the newborn, 4th ed. Philadelphia: WB Saunders, 2001:217-394
  3. Vannucci R, Perlman J. Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics. 1997;100:1004–1014
  4. Hill A, Volpe JJ. Perinatal asphyxia (Clinical aspects). Clin Perinatol. 1989;16:435–457
  5. Nagdyman N, Komen W, Ko H, Muller C, Obladen M. Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia. Pediatr Res. 2001;49(4):502–506
  6. Blennow M, Savman K, Ilves P, Thoresen M, Rosengren L. Brain-specific proteins in the cerebrospinal fluid of severely asphyxiated newborn infants. Acta Paediatr. 2001;90(10):1171–1175
  7. Thornberg E, Thiringer K, Hagberg H, Kjellmer I. Neuron specific enolase in asphyxiated newborns (Association with encephalopathy and cerebral function monitor trace). Arch Dis Child Fetal Neonatal Ed. 1995;72:F39–F42
  8. Hollander DI, Wright L, Nagey DA, Wright JN, Pupkin MJ, Koch T. Indicators of perinatal asphyxia. Am J Obstet Gynecol. 1987;157:839–843
  9. Hagberg H, Thornberg E, Blennow M. Excitatory amino acids in the cerebrospinal fluid of asphyxiated infants (Relationship to hypoxic-ischemic encephalopathy). Acta Paediatr. 1993;82:925–929
  10. Savman K, Blennow M, Gustafson K, Tarkowski E, Hagberg H. Cytokine response in cerebrospinal fluid after birth asphyxia. Pediatr Res. 1998;43:746–751
  11. Nangia S, Saili A, Dutta AK, Batra S, Ray GN. Free oxygen radicals—predictors of neonatal outcome following perinatal asphyxia. Indian J Pediatr. 1998;65(3):419–427
  12. Korst LM, Phelan JP, Ahn MO, Martin GI. Nucleated red blood cells (An update on the marker for fetal asphyxia). Am J Obstet Gynecol. 1996;175:843–846
  13. Phelan JP, Ahn MY, Korst LM, Martin GI. Nucleated red blood cells (A marker for fetal asphyxia?). Am J Obstet Gynecol. 1995;173:1380–1384
  14. Buonocore G, Perrone S, Gioia D, et al.  Nucleated red blood cell count at birth as an index of perinatal brain damage. Am J Obstet Gynecol. 1999;181:1500–1505
  15. Miller SP, Newton N, Ferriero DM, et al.  Predictors of 30-month outcome following perinatal depression (Role of proton MRS and socio-economic factors). Pediatr Res. 2002;52(1):71–77
  16. Barkovich AJ, Westmark KD, Bedi HS, Partridge JC, Ferriero DM, Vigneron DB. Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia (Preliminary report). Am J Neuroradiol. 2001;22(9):1786–1794
  17. Barkovich AJ, Baranski K, Vigneron D, et al.  Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. Am J Neuroradiol. 1999;20:1399–1405
  18. Hermansen MC. Nucleated red blood cells in the fetus and newborn. Arch Dis Child Fetal Neonatal Ed. 2001;84:F211–F215
  19. Richardson DK, Phibbs CS, Gray JE, McCormick MC, Workman-Daniels K, Goldmann DA. Birth weight and illness severity (Independent predictors of neonatal mortality). Pediatrics. 1993;91:969–975
  20. Newton NR, Miller SP, Ferriero DM, Kaufman SA, Barkovich AJ, Partridge JC. SNAP-PE as a predictor of neurodevelopmental outcome at 1 and 2.5 years of age following perinatal depression. Pediatr Res. 2001;49(4):310A
  21. Bayley N. The Bayley scales of infant development II. New York: New York Psychological Corporation; 1993;
  22. Hajnal BL, Sahebkar-Moghaddam F, Barnwell AJ, Barkovich AJ, Ferriero DM. Early prediction of neurologic outcome after perinatal depression. Pediatr Neurol. 1999;21:788–793
  23. Green DW, Mimouni F. Nucleated erythrocytes in healthy infants and in infants of diabetic mothers. J Pediatr. 1990;116:129–131
  24. Widness JA, Teramo KA, Clemons GK, et al.  Temporal response of immunoreactive erythropoietin to acute hypoxemia in fetal sheep. Pediatr Res. 1986;20(1):15–19
  25. Eckardt K, Boutellier U, Kurtz A, Schopin M, Koller EA, Bauer C. Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. J Appl Physiol. 1989;66:1785–1788
  26. Richardson DK, Gray JE, McCormick MC, Workman K, Goldmann DA. Score for neonatal acute physiology (A physiology severity index for neonatal intensive care). Pediatrics. 1993;91:617–623
  27. Huang C, Wang S, Chang Y, Lin K, Wu P. Measurement of urinary lactate (Creatinine ratio for the early identification of newborn infants at risk for hypoxic-ischemic encephalopathy). N Engl J Med. 1999;341:328–335
  28. Naeye RL, Localio AR. Determining the time before birth when ischemia and hypoxemia initiated cerebral palsy. Obstet Gynecol. 1995;86:713–719

PII: S0887-8994(03)00266-2

doi: 10.1016/S0887-8994(03)00266-2

Pediatric Neurology
Volume 29, Issue 4 , Pages 278-283 , October 2003