Pediatric Neurology
Volume 30, Issue 1 , Pages 39-41 , January 2004

Brainstem calcification in Möbius syndrome

  • Joseph M Dooley, MB, BCh

      Affiliations

    • Department of Pediatrics, Division of Pediatric Neurology, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada
    • Corresponding Author InformationCommunications should be addressed to: Dr. Dooley; Division of Pediatric Neurology; IWK Health Centre; 5850/5980 University Avenue; Halifax, NS B3J 3G9; Canada.
    • ,
  • Wendy A Stewart, MD, PhD

      Affiliations

    • Department of Pediatrics, Division of Pediatric Neurology, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada
    • ,
  • James D Hayden, MB, BCh

      Affiliations

    • Department of Pediatrics, Division of Pediatric Neurology, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada
    • ,
  • Arawn Therrien, MD

      Affiliations

    • Department of Pediatrics, Division of Pediatric Neurology, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada

Received 27 February 2003 ,Accepted 10 May 2003.

References 

  1. von Graefe A. In: von Graefe A, Saemisch T, eds. Handbuch der gerammten Augenheilkunde. Vol. 6. Leipzig: W Engelmann, 1880
  2. Möbius PJ. Über angeborene doppelseitige Abducens-Facialis-Lähmung. Munchener Med Wochenschr. 1888;35:91–94
  3. Möbius PJ. Über infantilen Kernschwund. Munch Med Wochenschr. 1892;39:17–21 41-3, 55-8
  4. Henderson JL. The congenital facial diplegia syndrome (Clinical features, pathology and etiology). A review of 61 cases. Brain. 1939;62:381–403
  5. Kumar D. Möbius syndrome. J Med Genet. 1990;27:122–126
  6. Elsahy NI. Moebius syndrome associated with the mother taking thalidomide during gestation. Case report. Plast Reconstr Surg. 1973;51:93–95
  7. Graham JM, Edwards MJ, Lipson AH, Webster WS, Edwards MJ. Gestational hyperthermia as a cause for Moebius syndrome. Teratology. 1988;37:461A
  8. Kankirawatana P, Tennison MB, D'Cruz O, Greenwood RS. Mobius syndrome in infant exposed to cocaine in utero. Pediatr Neurol. 1993;9:71–72
  9. Lipson AH, Webster WS, Brown-Woodman PDC, Osborn RA. Moebius syndrome (Animal model–human correlations and evidence for a brainstem vascular etiology). Teratology. 1989;40:339–350
  10. Lipson T, Webster W, Weaver DD. The Moebius syndrome (Aetiology, incidence of mental retardation, and genetics). J Med Genet. 1990;27:533–534
  11. Merz M, Wojtowicz S. Fetal damage as a cause of Moebius syndrome. Klin Oczna. 1966;36:623–627
  12. Pastuszak AL, Schuler L, Speck-Martins CE, et al.  Use of misoprostol during pregnancy and Mobius syndrome in infants. N Engl J Med. 1998;338:1881–1885
  13. Sherer DM, Spafford P. Prenatal sonographic evidence supporting an in utero developmental etiology of Möbius sequence. Am J Perinatol. 1994;11:157–159
  14. Shepard TH. Mobius syndrome after misoprostol (A possible teratogenic mechanism). [letter] Lancet. 1995;346:780
  15. Sudarshan A, Goldie WD. The spectrum of congenital facial diplegia (Moebius syndrome). Pediatr Neurol. 1985;1:180–184
  16. Superneau DW, Wertelecki W. Similarity of effects—experimental hyperthermia as a teratogen and maternal febrile illness associated with oromandibular and limb defects. Am J Med Genet. 1985;21:575–580
  17. Thakkar N, O'Neil W, Duvally J, Liu C, Ambler M. Moebius syndrome due to brain stem tegmental necrosis. Arch Neurol. 1977;34:124–126
  18. Towfighi J, Marks K, Palmer E, Vannucci R. Möbius syndrome (Neuropathologic observations). Acta Neuropathol (Berl). 1979;48:11–17
  19. Wilson ER, Mirra SS, Schwartz JF. Congenital diencephalic and brain stem damage (Neuropathologic study of three cases). Acta Neuropathol. 1982;57:70–74
  20. Richter RB. Congenital hypoplasia of the facial nucleus. J Neuropathol Exp Neurol. 1958;17:520
  21. Pedraza S, Gamez J, Rovira A, et al.  MRI findings in Mobius syndrome (Correlation with clinical features). Neurology. 2000;55:1058–1060
  22. Barrow JR, Capecchi MR. Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4. Development. 1996;122:3817–3828
  23. Beerbower J, Chakeres DW, Larsen PD, Kapila A. Radiographic findings in Moebius and Moebius-like syndromes. Am J Neurol Radiol. 1986;7:364–365
  24. Kuhn MJ, Clark HB, Morales A, Shekar PC. Group III Mobius syndrome (CT and MR findings). AJNR Am J Neuroradiol. 1990;11:903–904

PII: S0887-8994(03)00408-9

doi: 10.1016/S0887-8994(03)00408-9

Pediatric Neurology
Volume 30, Issue 1 , Pages 39-41 , January 2004

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