Pediatric Neurology
Volume 30, Issue 3 , Pages 219-221, March 2004

A lethal association of congenital apnea with brainstem tegmental necrosis

  • Martin P Moya, MD

      Affiliations

    • Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    • ,
  • G.Robert Delong, MD

      Affiliations

    • Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    • Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA
    • ,
  • Daniel Barboriak, MD

      Affiliations

    • Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA
    • ,
  • Thomas J Cummings, MD

      Affiliations

    • Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA
    • Corresponding Author InformationCommunications should be addressed to:Dr. Moya; Duke University Medical Center; Department of Pathology, Box 3936; Durham, NC 27710, USA.

Received 15 April 2003; accepted 24 July 2003.

Abstract 

We present a female with premature birth, polyhydramnios, congenital apnea, cranial nerve palsies, orofacial and limb anomalies. Neuroimaging revealed calcifications along the vental margin of the caudal fourth ventricle. Neuropathologic findings at postmortem examination were consistent with brainstem tegmental necrosis and olivary hypoplasia, a rare lethal entity that should be considered in the differential diagnosis of congenital apnea.

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PII: S0887-8994(03)00445-4

doi:10.1016/j.pediatrneurol.2003.07.007

Pediatric Neurology
Volume 30, Issue 3 , Pages 219-221, March 2004

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