Pediatric Neurology
Volume 31, Issue 5 , Pages 374-377 , November 2004

Paralytic ileus in MELAS with phenotypic features of MNGIE

  • Tung-Ming Chang, MD

      Affiliations

    • Department of Pediatric Neurology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    • ,
  • Ching-Shiang Chi, MD

      Affiliations

    • Department of Pediatric Neurology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    • Corresponding Author InformationCommunications should be addressed to:Dr. Chi; Department of Pediatrics; Taichung Veterans General Hospital; No. 160, Sec 3, Chung-Kang Rd.; Taichung 407, Taiwan
    • ,
  • Chi-Ren Tsai, MSc

      Affiliations

    • Department of Pediatric Neurology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    • ,
  • Hsiu-Fen Lee, MD

      Affiliations

    • Department of Pediatric Neurology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    • ,
  • Mu-Chun Li, MD

      Affiliations

    • Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC

Received 3 November 2003 ,Accepted 21 May 2004.

References 

  1. Hirano M , Pavlakis SG . Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS): Current concepts . J Child Neurol . 1994;9:4–13
  2. Hirano M , Silvestri G , Blake DM , et al.  Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): Clinical, biochemical, and genetic features of an autosomal recessive mitochondrial disorder . Neurology . 1994;44:721–727
  3. Nishino I , Spinazzola A , Hirano M . MNGIE: From nuclear DNA to mitochondrial DNA . Neuromuscul Disord . 2001;11:7–10
  4. Yamamoto M , Sato T , Anno M , Ujike H , Takemoto M . Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes with recurrent abdominal symptoms and coenzyme Q10 administration . J Neurol Neurosurg Psychiatry . 1987;50:1475–1481
  5. Mori O , Yamazaki M , Ohaki Y , et al.  Mitochondrial encephalomyopathy with lactic acidosis and stroke like episodes (MELAS) with prominent degeneration of the intestinal wall and cactus-like cerebellar pathology . Acta Neuropathol (Berl) . 2000;100:712–717
  6. Hiel JA , Verrips A , Keyser A , et al.  Ileus in mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes . Neth J Med . 1998;53:27–31
  7. Shimotake T , Furukawa T , Inoue K , Iwai N , Takeuchi Y . Familial occurrence of intestinal obstruction in children with the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) . J Pediatr Surg . 1998;33:1837–1839
  8. Kuroiwa T , Kuwata T , Nakayama T , et al.  Mitochondrial encephalomyopathy showing prominent microvacuolation and necrosis of intestinal smooth muscle cells: A case diagnosed by rectal biopsy . Acta Neuropathol (Berl) . 1998;96:86–90
  9. Nishino I , Spinazzola A , Papadimitriou A , et al.  Mitochondrial neurogastrointestinal encephalomyopathy: An autosomal recessive disorder due to thymidine phosphorylase mutations . Ann Neurol . 2000;47: 792-80
  10. Vissing J , Ran K , Danielsen E , et al.  Multiple mtDNA deletions with features of MNGIE . Neurology . 2002;59:926–929
  11. Perez-Atayde AR , Fox V , Teitelbaum JE , et al.  Mitochondrial neurogastrointestinal encephalomyopathy: Diagnosis by rectal biopsy . Am J Surg Pathol . 1998;22:1141–1147
  12. van den Ouweland JM , Lemkes HH , Trembath RC , et al.  Maternally inherited diabetes and deafness is a distinct subtype of diabetes and associates with a single point mutation in the mitochondrial tRNA(Leu(UUR)) gene . Diabetes . 1994;43:746–751
  13. Schuffler MD , Deitch EA . Chronic idiopathic intestinal pseudo-obstruction: A surgical approach . Ann Surg . 1980;192:752–761

PII: S0887-8994(04)00287-5

doi: 10.1016/j.pediatrneurol.2004.05.009

Pediatric Neurology
Volume 31, Issue 5 , Pages 374-377 , November 2004

Article Tools

* Image Usage & Resolution