Pediatric Neurology
Volume 31, Issue 5 , Pages 367-370 , November 2004

Hypersomnia and low cerebrospinal fluid hypocretin levels in acute disseminated encephalomyelitis

  • Sosuke Yoshikawa, MD

      Affiliations

    • Department of Pediatrics, Osaka Medical College, Osaka, Japan
    • ,
  • Shuhei Suzuki, MD, PhD

      Affiliations

    • Department of Pediatrics, Osaka Medical College, Osaka, Japan
    • Corresponding Author InformationCommunications should be addressed to:Dr. Suzuki; Department of Pediatrics; Osaka Medical College; 2-7 Daigaku-machi, Takatsuki; Osaka 569-8686, Japan
    • ,
  • Takashi Kanbayashi, MD, PhD

      Affiliations

    • Department of Neuropsychiatry, Akita University School of Medicine, Akita, Japan
    • ,
  • Seiji Nishino, MD, PhD

      Affiliations

    • Center for Narcolepsy, Stanford University, California
    • ,
  • Hiroshi Tamai, MD, PhD

      Affiliations

    • Department of Pediatrics, Osaka Medical College, Osaka, Japan

Received 18 February 2004 ,Accepted 27 May 2004.

References 

  1. Willie JT , Chemelli RM , Sinton CM , Yanagisawa M . To eat or to sleep? . Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci . 2001;24:429–458
  2. Peyron C , Faraco J , Rogers W , et al.  A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains . Nat Med . 2000;6:991–997
  3. Nishino S , Ripley B , Nevsimalova S , et al.  Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy . Ann Neurol . 2001;50:381–388
  4. Arii J , Kanbayashi T , Tanabe Y , Ono J , Nishino S , Kohno Y . A hypersomnolent girl with decreased CSF hypocretin level after removal of a hypothalamic tumor . Neurology . 2001;56:1775–1776
  5. Melberg A , Ripley B , Lin L , Hetta J , Mignot E , Nishino S . Hypocretin deficiency in familial symptomatic narcolepsy . Ann Neurol . 2001;49:136–137
  6. Scammell TE , Nishino S , Mignot E , Saper CB . Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke . Neurology . 2001;56:1751–1753
  7. Kubota H , Kanbayashi T , Tanabe Y , Takanashi J , Kohno Y . A case of acute disseminated encephalomyelitis presenting hypersomnia with decreased hypocretin level in cerebrospinal fluid . J Child Neurol . 2002;17:537–539
  8. von Economo C . Encephalitis lethargica: Its sequelae and treatment . London: Oxford University Press; 1931;
  9. Kanbayashi T , Goto A , Hishikawa Y , et al.  Hypersomnia due to acute disseminated encephalomyelitis in a 5-year-old girl . Sleep Medicine . 2001;2:347–350

PII: S0887-8994(04)00348-0

doi: 10.1016/j.pediatrneurol.2004.05.014

Pediatric Neurology
Volume 31, Issue 5 , Pages 367-370 , November 2004

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