Pediatric Neurology
Volume 32, Issue 4 , Pages 241-247 , April 2005

Postneonatal epilepsy following amplitude-integrated EEG-detected neonatal seizures

  • Mona C. Toet, MD

      Affiliations

    • Department of Neonatology, University Medical Center Utrecht/Wilhelmina Children’s Hospital, Utrecht, The Netherlands
    • ,
  • Floris Groenendaal, MD, PhD

      Affiliations

    • Department of Neonatology, University Medical Center Utrecht/Wilhelmina Children’s Hospital, Utrecht, The Netherlands
    • ,
  • Damjan Osredkar, MD

      Affiliations

    • Department of Neonatology, University Medical Center Utrecht/Wilhelmina Children’s Hospital, Utrecht, The Netherlands
    • ,
  • Alexander C. van Huffelen, MD, PhD

      Affiliations

    • Department of Clinical Neurophysiology, University Medical Center Utrecht/Wilhelmina Children’s Hospital, Utrecht, The Netherlands
    • ,
  • Linda S. de Vries, MD, PhD

      Affiliations

    • Department of Neonatology, University Medical Center Utrecht/Wilhelmina Children’s Hospital, Utrecht, The Netherlands
    • Corresponding Author InformationCommunications should be addressed to: Dr. de Vries; Department of Neonatology, KE 04.123.1; University Medical Center Utrecht/Wilhelmina Children’s Hospital; PO Box 85090; 3508 AB Utrecht; The Netherlands

Received 4 August 2004 ,Accepted 8 November 2004.

References 

  1. Volpe JJ . In: Neurology of the newborn . 4th ed.. Philadelphia: W.B. Saunders; 2001;p. 172–207
  2. Boylan GB , Pressler RM , Rennie JM , et al.   Outcome of electroclinical, electrographic, and clinical seizures in the newborn infant . Dev Med Child Neur . 1999;41:819–825
  3. Scher MS , Alvin J , Gaus L , Minnigh B , Painter MJ . Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use . Pediatr Neurol . 2003;28:277–280
  4. Miller SP , Weiss J , Barnwell A , et al.   Seizure-associated brain injury in term newborns with perinatal asphyxia . Neurology . 2002;58:542–548
  5. McBride MC , Laroia N , Guillet R . Electrographic seizures in neonates correlate with poor neurodevelopmental outcome . Neurology . 2000;55:506–513
  6. Liu Z , Yang Y , Silveira DC , et al.   Consequences of recurrent seizures during early brain development . Neuroscience . 1999;92:1443–1454
  7. Holmes GL , Gairsa JL , Chevassus-au-Louis N , Ben-Ari Y . Consequences of neonatal seizures in the rat (Morphological behavioural effects) . Ann Neurol . 1998;44:845–857
  8. Holmes GL . Seizure-induced neuronal injury . Neurology . 2002;59:S3–S6
  9. Wirrell EC , Armstrong EA , Osman LD , Yager JY . Prolonged seizures exacerbate perinatal hypoxic-ischemic brain damage . Pediatr Res . 2001;50:445–454
  10. Bittigau P , Sifringer M , Genz K , et al.   Antiepileptic drugs and apoptosis in the developing brain . PNAS . 2002;99:15089–15094 (Ann NY Acad Sci 2003;993:103–4)
  11. Clancy RR , Legido A . Postnatal epilepsy after EEG-confirmed neonatal seizures . Epilepsia . 1991;32:69–76
  12. Brunquell PJ , Glennon CS , Dimario FJ , Lerer T , Eisenfeld L . Prediction of outcome based on clinical seizure type in newborn infants . J Pediatr . 2002;140:707–712
  13. Hellström-Westas L , Blennow G , Lindroth M , Rosén I , Svenningsen NW . Low risk of seizure recurrence after early withdrawal of anti-epileptic treatment in the neonatal period . Arch Dis Child . 1995;72:F97–F101
  14. Toet MC , van der Meij W , de Vries LS , van Huffelen AC . Comparison between simultaneously recorded amplitude integrated EEG (Cerebral Function Monitor) and standard EEG in neonates . Pediatrics . 2002;109:772–779
  15. Sarnat HB , Sarnat MS . Neonatal encephalopathy following fetal distress (A clinical and electroencephalographic study) . Arch Neurol . 1976;33:696–705
  16. Hellström-Westas L , Rosén I , Svenningsen NW . Silent seizures in sick infants in early life (Diagnosis by continuous cerebral function monitoring) . Acta Paediatr Scand . 1985;74:741–748
  17. Thornberg E , Thiringer K . Normal patterns of cerebral function monitor traces in term and preterm neonates . Acta Paediatr Scand . 1990;79:20–25
  18. Hellström-Westas L . Comparison between tape-recorded and amplitude-integrated EEG monitoring in sick newborn infants . Acta Paediatr Scand . 1992;81:812–819
  19. Bjerre I , Hellström-Westas L , Rosen I , Svenningsen NW . Monitoring of cerebral function after asphyxia in infancy . Arch Dis Child . 1983;58:997–1002
  20. Toet MC , Hellström-Westas L , Groenendaal F , Eken P , de Vries LS . Amplitude integrated EEG at 3 and 6 hours after birth in fullterm neonates with hypoxic ischemic encephalopathy . Arch Dis Child . 1999;81:F19–F23
  21. Hellström-Westas L , de Vries LS , Rosén I . An atlas of amplitude-integrated EEGs in the newborn . London: Parthenon Publishing Group; 2003; pp. 23–7, 51–65
  22. Griffiths R . The abilities of babies (A study in mental measurement) . Amersham: Association of Research in Infant and Child Development; 1976;
  23. Amiel-Tison C , Grenier A . Evaluation neurologique du nouveau-né et du nourisson . Paris: Masson; 1980;
  24. Touwen BLC . Examination of the child with minor neurological dysfunction. Clinics in Developmental Medicine No. 71 . London: SIMP/Heinemann; 1979;
  25. Piper MC , Darrah J . Motor assessment of the developing infant . Philadelphia: W.B. Saunders; 1994;
  26. Hagberg B , Hagberg G , Olow I . The changing panorama of cerebral palsy in Sweden. I. Analysis of general changes . Acta Paediatr Scand . 1975;64:187–192
  27. Screenan C , Bhargava R , Roberton CMT . Cerebral infarction in the term newborn (Clinical presentation and long-term outcome) . J Pediatr . 2000;136:351–355
  28. Menache CC , Bourgeois BFD , Volpe J . Prognostic value of neonatal discontinuous EEG . Pediatr Neurol . 2002;27:93–101
  29. Painter MJ , Sher MS , Stein AD , et al.   Phenobarbital compared with phenytoin for the treatment of neonatal seizures . N Engl J Med . 1999;341:485–489
  30. Mizrahi EM , Kellaway  . In: Diagnosis and management of neonatal seizures . Philadelphia-New York: Lippincott-Raven; 1998;p. 61–85
  31. Hellström-Westas L , Westgren U , Rosén I , Svenningsen NW . Lidocaine for treatment of severe seizures in newborn infants. I. Clinical effects and cerebral electrical activity monitoring . Acta Paediatr Scand . 1988;77:79–84
  32. Hellström-Westas L , Svenningsen NW , Westgren U , Rosén I , Lagerstrom PO . Lidocaine for treatment of severe seizures in newborn infants. II. Blood concentrations of lidocaine and metabolites during intravenous infusion . Acta Paediatr . 1992;81:35–39
  33. Sheth RD , Buckley DJ , Gutierrez AR , Gingold M , Bodensteiner JB , Penney S . Midazolam in the treatment of refractory neonatal seizures . Clin Neuropharmacol . 1996;19:165–170
  34. Jacqz-Aigrain E , Daoud P , Burtin P , Maherzi S , Beaufils F . Pharmacokinetics of midazolam during continuous infusion in critically ill neonates . Eur J Clin Pharmacol . 1992;42:329–332
  35. Boylan GB , Rennie JM , Chorley G , et al.   Second-line anticonvulsant treatment of neonatal seizures . Neurology . 2004;62:486–488
  36. Van Leuven K , Groenendaal F , Toet MC , et al.   Midazolam and amplitude-integrated EEG in asphyxiated full-term neonates . Acta Paediatr . 2004;93:1–7
  37. Connell J , Oozeer R , de Vries L , Dubowitz LM , Dubowitz V . Clinical and EEG response to anticonvulsants in neonatal seizures . Arch Dis Child . 1989;64:459–464
  38. Bye AM , Flanagan D . Spatial and temporal characteristics of neonatal seizures . Epilepsia . 1995;36:1009–1016
  39. Brenner R . Is it status? . Epilepsia . 2002;43(Suppl. 3):103–113
  40. Delorenzo RJ , Waterhous EJ , Towne AR , et al.   Persistent nonconvulsive status epilepticus after control of convulsive status epilepticus . Epilepsia . 1998;39:833–840
  41. Boylan GB , Panerai RB , Rennie JM , Evans DH , Rabe-Hesketh S , Binnie CD . Cerebral blood flow velocity during neonatal seizures . Arch Dis Child . 1999;80:F105–F110
  42. Younkin DP , Delivoria Papadopoulos M , Maris J , Donlon E , Clancy R , Chance B . Cerebral metabolic effects of neonatal seizures measured with in vivo 31P NMR spectroscopy . Ann Neurol . 1986;20:513–519
  43. Oliveira AJ , Nunes M , Haertel LM , Reis FM , da Costa JC . Duration of rhythmic EEG patterns in neonates (New evidence for clinical and prognostic significance of brief rhythmic discharges) . Clin Neurophysiol . 2000;111:1646–1653
  44. Rennie JM , Boylan GB . Neonatal seizures and their treatment . Curr Opin Neurol . 2003;16:177–181

PII: S0887-8994(04)00561-2

doi: 10.1016/j.pediatrneurol.2004.11.005

Pediatric Neurology
Volume 32, Issue 4 , Pages 241-247 , April 2005

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