Pediatric Meningosarcoma: Clinical Evolution and Genetic Instability

de Mesa, Reyes López; Sierrasesúmaga, Luis; de Cerain, Adela López; Calasanz, María José; Patiño-García, Ana

doi:10.1016/j.pediatrneurol.2004.11.010

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Volume 32, Issue 5 , Pages 352-354, May 2005

Pediatric Meningosarcoma: Clinical Evolution and Genetic Instability

Reyes López de Mesa, MD
- Laboratory and Department of Pediatrics, University Clinic and University of Navarra, Pamplona, Spain.
Luis Sierrasesúmaga, MD, PhD
- Laboratory and Department of Pediatrics, University Clinic and University of Navarra, Pamplona, Spain.
Adela López de Cerain, PhD
- Laboratory of Toxicology, University Clinic and University of Navarra, Pamplona, Spain.
María José Calasanz, PhD
- Department of Genetics, University Clinic and University of Navarra, Pamplona, Spain.
Ana Patiño-García, PhD
- Laboratory and Department of Pediatrics, University Clinic and University of Navarra, Pamplona, Spain.
- Communications should be addressed to: Dr. Patiño-García; Laboratory of Pediatrics; “Los Castaños” Building; University of Navarra; E31080 Pamplona, Spain.

Received 2 September 2004; accepted 29 November 2004. published online 22 March 2005.

This report presents a female diagnosed with a frontoparietal interhemispheric meningosarcoma who, parallel to the clinical worsening, revealed an increase in the genetic instability (in bleomycin cultures) and the complexity of the karyotypes, with the acquisition of a clonal deletion of 17p13 (the locus for the TP53 tumor suppressor gene). The genetic findings of this patient suggest that the increased genetic instability could contribute to tumor progression as well as to treatment resistance, possibly in the background of the clonal deletion of TP53.