Pediatric Neurology
Volume 32, Issue 5 , Pages 352-354 , May 2005

Pediatric Meningosarcoma: Clinical Evolution and Genetic Instability

  • Reyes López de Mesa, MD

      Affiliations

    • Laboratory and Department of Pediatrics, University Clinic and University of Navarra, Pamplona, Spain.
    • ,
  • Luis Sierrasesúmaga, MD, PhD

      Affiliations

    • Laboratory and Department of Pediatrics, University Clinic and University of Navarra, Pamplona, Spain.
    • ,
  • Adela López de Cerain, PhD

      Affiliations

    • Laboratory of Toxicology, University Clinic and University of Navarra, Pamplona, Spain.
    • ,
  • María José Calasanz, PhD

      Affiliations

    • Department of Genetics, University Clinic and University of Navarra, Pamplona, Spain.
    • ,
  • Ana Patiño-García, PhD

      Affiliations

    • Laboratory and Department of Pediatrics, University Clinic and University of Navarra, Pamplona, Spain.
    • Corresponding Author InformationCommunications should be addressed to: Dr. Patiño-García; Laboratory of Pediatrics; “Los Castaños” Building; University of Navarra; E31080 Pamplona, Spain.

Received 2 September 2004 ,Accepted 29 November 2004.

References 

  1. Haddad GF , Al-Mefty O . Meningeal sarcomas . In:  Kaye AH ,  Laws ER editor. Brain tumors (An encyclopedic approach) . Toronto: Churchill Livingstone; 2001;p. 713–724
  2. Paulus W , Scheithauer BW . Mesenchymal, non-meningothelial tumours . In:  Kleihues P ,  Cavenee WK editor. Pathology and genetics of tumours of the nervous system . Lyon: IARC Press; 2000;p. 185–189
  3. Weber RG , Boström J , Wolter M , et al.   Analysis of genomic alterations in benign, atypical and anaplastic meningiomas (Toward a genetic model of meningioma progression) . Proc Natl Acad Sci USA . 1997;94:14719–14724
  4. Lamszus K , Kluwe L , Matschke J , Meissner H , Laas R , Westphal M . Allelic losses at 1p, 9q, 10q, 14q and 22q in the progression of aggressive meningiomas and undifferentiated meningeal sarcomas . Cancer Genet Cytogenet . 1999;110:103–110
  5. Lopez de Mesa R , Lopez de Cerain Salsamendi A , Ariznabarreta LS , Calasanz Abinzano MJ , Patino-Garcia A . Measurement and analysis of the chemotherapy-induced genetic instability in pediatric cancer patients . Mutagenesis . 2002;17:171–175
  6. Mitelman F . ISCN. An international system for human cytogenetic nomenclature . Basel: S. Karger; 1995;
  7. Simon M , Kokkino AJ , Warnick RE , Tew JM , von Demling A , Menon AG . Role of genomic instability in meningioma progression . Genes Chromosom Cancer . 1996;16:265–269
  8. Aguiar PH , Agner C , Simm R , Freitas AB , Tsanaclis AM , Plese P . p53 Protein expression in meningiomas—a clinicopathologic study of 55 patients . Neurosurg Rev . 2002;25:252–257
  9. Verheijen FM , Sprong M , Kloosterman JM , Blaauw G , Thijssen JH , Blankenstein MA . TP53 mutations in human meningiomas . Int J Biol Markers . 2002;17:42–48
  10. Kamei Y , Watanabe M , Nakayama T , Kanamaru K , Waga S , Shiraishi T . Prognostic significance of p53 and p21WAF1/CIP1 immunoreactivity and tumor micronecrosis for recurrence of meningiomas . J Neurooncol . 2000;46:205–213
  11. Pai SA , Cheung MC , Romsdahl MM , Multani AS , Pathak S . Can genetic instability be studied at the single chromosome level in cancer cells? Evidence from human melanoma cells . Cancer Genet Cytogenet . 1999;109:51–57

PII: S0887-8994(04)00566-1

doi: 10.1016/j.pediatrneurol.2004.11.010

Pediatric Neurology
Volume 32, Issue 5 , Pages 352-354 , May 2005

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