Poland-Möbius syndrome and cocaine abuse: A relook at vascular etiology

Puvabanditsin, Surasak; Garrow, Eugene; Augustin, Gerda; Titapiwatanakul, Ruetima; Kuniyoshi, Katherine M.

doi:10.1016/j.pediatrneurol.2004.11.011

« Previous Next »Pediatric Neurology
Volume 32, Issue 4 , Pages 285-287, April 2005

Poland-Möbius syndrome and cocaine abuse: A relook at vascular etiology

Surasak Puvabanditsin, MD
- Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Newark, New Jersey
- Department of Pediatrics, Jersey City Medical Center, Jersey City, New Jersey
- Communications should be addressed to: Dr. Puvabanditsin; Department of Pediatrics; Jersey City Medical Center; 355 Grand Street; Jersey City, NJ 07302
Eugene Garrow, MD
- Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, New Jersey
Gerda Augustin, MD
- Department of Pediatrics, Jersey City Medical Center, Jersey City, New Jersey
Ruetima Titapiwatanakul, MD
- Department of Pediatrics, Jersey City Medical Center, Jersey City, New Jersey
Katherine M. Kuniyoshi, MD
- Department of Pediatrics, Jersey City Medical Center, Jersey City, New Jersey

Received 17 August 2004; accepted 8 November 2004. published online 07 March 2005.

This report presents a severe case of Poland-Möbius syndrome with central apnea at birth, ventilator-dependent, and with brainstem calcifications. The newborn had unilateral defect of the right pectoralis muscle, breast, and limb. He manifested bilateral paralysis of the cranial nerves resulting in shallow respiration, apnea, and dysphagia. He finally required tracheostomy and gastrostomy. Maternal history revealed multiple uses of cocaine during the first 3 months of pregnancy. The patient supports the Poland-Möbius combination and the possibility of vascular disruption sequence.