Pediatric Neurology
Volume 32, Issue 5 , Pages 295-299 , May 2005

Rasmussen’s Syndrome: Progressive Autoimmune Multi-Focal Encephalopathy

  • John M. Freeman, MD

      Affiliations

    • Corresponding Author InformationCommunications should be addressed to: Dr. Freeman; Johns Hopkins Medical Institutions; Meyer 2-147, Johns Hopkins Hospital; Baltimore, MD 21287-7247.

Received 2 September 2004 ,Accepted 13 December 2004.

References 

  1. Rasmussen T , Olszewski J , Lloyd-Smith D . Focal seizures due to chronic localized encephalitis . Neurology . 1958;8:435–445
  2. Rasmussen T . Further observations on the syndrome of chronic encephalitis and epilepsy . Appl Neurophysiol . 1978;41:1–12
  3. Piatt JH , Hwang PA , Armstrong DC , et al.   Chronic focal encephalitis (Rasmussen syndrome) (Six cases) . Epilepsia . 1988;29:268–279
  4. Rasmussen T . Hemispherectomy for seizures revisited . Canad J Neurol Sci . 1983;10;:71–78
  5. Freeman JM , Vining EPG , Carson BS , Brandt J . Hemispherectomy in children (The Hopkins experience, 1968–1988, a preliminary report) . J Epilepsy . 1990;108(13):169–176
  6. Oguni H , Anderman F , Rasmussen T . The natural history of the syndrome of chronic encephalitis and epilepsy . In:  Anderman F editors. Chronic encephalitis and epilepsy (Rasmussen’s syndrome) . Boston: Butterworth-Heinemann; 1991;
  7. Andrews PI , Dichter MA , Berkovic SF , Newton MR , McNamara JO . Plasmaphoresis in Rasmussen’s encephalitis . Neurology . 2001;57:S37–S41
  8. Granata T , Fusco L , Gobbi G , et al.   Experience with immunomodulatory treatments in Rasmussen’s encephalitis . Neurology . 2003;61(12):1807–1810
  9. Vining EPG , Freeman JM , Brandt J , Carson BS , Uematsu S . Progressive unilateral encephalopathy of childhood (Rasmussen’s syndrome) (A reappraisal) . Epilepsia . 1993;34(4):639–650
  10. Vining EPG , Freeman JM , Pillas DJ , et al.   Why would your remove half a brain? The outcome of 58 children after hemispherectomy . Pediatrics . 1997;100:163–171
  11. Jonas R , Nguyen S , Hu B , et al.   Cerebral hemispherectomy (Hospital course, seizure, developmental, language, and motor outcomes) . Neurology . 2004;62(10):1712–1721
  12. Mantegazza R , Bernasconi P , Baggi F , et al.   Antibodies against GluR3 peptides are not specific for Rasmussen’s encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures . J Neuroimmunol . 2002;131(1–2):179–185
  13. Carson BS , Javedan SP , Freeman JM , et al.   Hemispherectomy (A hemi-decortication approach and review of 52 cases) . J. Neurosurg . 1996;84:903–911
  14. Schramm J , Kral T , Clusmann H . Transsylvian keyhole functional hemispherectomy . Neurosurgery . 2001;49:891–900
  15. Duchowney M . Hemispherectomy for epilepsy . Neurology . 2004;62:1664–1665
  16. Pulsifer MB , Brandt J , Salorio CF , Vining EPG , Carson BS , Freeman JM . The cognitive outcome of hemispherectomy in 71 children . Epilepsia . 2004;45(3):243–254
  17. Kossoff EH , Vining EPG , Pillas DJ , et al.   Hemispherectomy for intractable uni-hemispheric epilepsy (Etiology vs. outcome) . Neurology . 2003;61:887–890
  18. Kossoff EH , Vining EPG , Pysik PL , et al.   The postoperative course and management of 106 hemi-decortications . Ped Neurosurg . 2002;37:298–303
  19. Oppenheimer DR , Griffith HB . Persistent intracranial bleeding as a complication of hemispherectomy . J Neurol Neurosurg Psychiatry . 1966;29:229–240
  20. Boatman D , Freeman JM , Vining EPG , et al.   Language recovery after left hemispherectomy in children with late onset seizures . Ann Neurol . 1999;46:579–586
  21. Stark RE , Bleile K , Brandt J , Freeman JM , Vining EPG . Speech-language outcomes of hemispherectomy in children and young adults . Brain and Language . 1995;51:406–421
  22. Boatman D , Vining EPG , Freeman JM , Carson B . Auditory processing studied prospectively in two hemispherectomy patients . J Child Neurol . 2003;3:228–232
  23. Robitaille Y . Neuropathologic aspects of chronic encephalitis . In:  Anderman F editors. Chronic encephalitis and epilepsy (Rasmussen’s syndrome) . Boston: Butterworth-Heinemann; 1991;p. 79–110
  24. Pardo CA , Vining EPG , Guo L , Skolansky R , Carson BS , Freeman JM . The pathology of Rasmussen syndrome (Stages of cortical involvement and neuropathological studies in 45 hemispherectomies) . Epilepsia . 2004;45(5):516–526
  25. Bien CG , Bauer J , Deckworth TL , et al.   Destruction of neurons by cytotoxic T cells (A new pathogenic mechanism in Rasmussen’s encephalitis) . Ann Neurol . 2002;51:311–318
  26. Drachman DB , Jones RJ , Brodsky RA . Treatment of refractory myasthenia (“Rebooting” with high-dose cyclophosphamide) . Ann Neurol . 2003;53(1):29–34

PII: S0887-8994(05)00026-3

doi: 10.1016/j.pediatrneurol.2004.12.002

Pediatric Neurology
Volume 32, Issue 5 , Pages 295-299 , May 2005