Pediatric Neurology
Volume 33, Issue 3 , Pages 179-183 , September 2005

Dopamine Transporter in Attention-Deficit Hyperactivity Disorder Normalizes After Cessation of Methylphenidate

  • Frans J.M. Feron, MD

      Affiliations

    • Youth Health Care Division of the Regional Public Health Institute Maastricht, Maastricht, The Netherlands
    • Corresponding Author InformationCommunications should be addressed to: Dr. Feron; Youth Health Care Division of the Regional Public Health Institute Maastricht; PO Box 3973; 6202 NZ Maastricht; The Netherlands.
  • ,
  • Jos G.M. Hendriksen, PhD

      Affiliations

    • Department of Child Neurology, University Hospital Maastricht, Maastricht, The Netherlands
    • Department of Psychiatry and Neuropsychology, University Hospital Maastricht, Maastricht, The Netherlands
  • ,
  • Marinus J.P.G. van Kroonenburgh, MD, PhD

      Affiliations

    • Department of Nuclear Medicine, University Hospital Maastricht, Maastricht, The Netherlands
  • ,
  • Ciska Blom-Coenjaerts

      Affiliations

    • Department of Nuclear Medicine, University Hospital Maastricht, Maastricht, The Netherlands
  • ,
  • Alfons G.H. Kessels, MD

      Affiliations

    • Department of Clinical Epidemiology and Medical Technology Assessment, University Hospital Maastricht, Maastricht, The Netherlands
  • ,
  • Jelle Jolles, PhD

      Affiliations

    • Department of Psychiatry and Neuropsychology, University Hospital Maastricht, Maastricht, The Netherlands
  • ,
  • Wim E.J. Weber, MD, PhD

      Affiliations

    • Department of Neurology, University Hospital Maastricht, Maastricht, The Netherlands
  • ,
  • Johan S.H. Vles, MD, PhD

      Affiliations

    • Department of Child Neurology, University Hospital Maastricht, Maastricht, The Netherlands
    • Department of Neurology, University Hospital Maastricht, Maastricht, The Netherlands

Received 30 December 2004 ,Accepted 18 April 2005.

References 

  1. National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up . Changes in effectiveness and growth after the end of treatment . Pediatrics . 2004;113:762–769
  2. Conners CK . Forty years of methylphenidate treatment in Attention-Deficit/Hyperactivity Disorder . J Atten Disord . 2002;6(Suppl. 1):S17–S30
  3. Jensen P . Longer term effects of stimulant treatments for Attention-Deficit/Hyperactivity Disorder . J Atten Disord . 2002;6(Suppl. 1):S45–S56
  4. Volkow ND , Fowler JS , Wang G , Ding Y , Gatley SJ . Mechanism of action of methylphenidate (Insights from PET imaging studies) . J Atten Disord . 2002;6(Suppl. 1):S31–S43
  5. Moderators and mediators of treatment response for children with attention-deficit/hyperactivity disorder . The Multimodal Treatment Study of children with Attention-deficit/hyperactivity disorder . Arch Gen Psychiatry . 1999;56:1088–1096
  6. Seeman P , Madras BK . Anti-hyperactivity medication (Methylphenidate and amphetamine) . Mol Psychiatry . 1998;3:386–396
  7. Biederman J , Spencer T . Methylphenidate in treatment of adults with Attention-Deficit/Hyperactivity Disorder . J Atten Disord . 2002;6(Suppl. 1):S101–S107
  8. Yuan J , McCann U , Ricaurte G . Methylphenidate and brain dopamine neurotoxicity . Brain Res . 1997;767:172–175
  9. Dresel S , Krause J , Krause KH , et al.   Attention deficit hyperactivity disorder (Binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment) . Eur J Nucl Med . 2000;27:1518–1524
  10. Cheon KA , Ryu YH , Kim YK , Namkoong K , Kim CH , Lee JD . Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder . Eur J Nucl Med Mol Imaging . 2003;30:306–311
  11. Vles JS , Feron FJ , Hendriksen JG , Jolles J , van Kroonenburgh MJ , Weber WE . Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD) . Neuropediatrics . 2003;34:77–80
  12. Kaufman AS , Kaufman NL . Kaufman Assessment Battery for Children. Interpretive manual . Circle Pines, Minnesota: American Guide Service; 1983;
  13. Hendriksen JGM , Feron FJM , Njiokiktjien C , Vles JSH . Het effect van clonidine en methylfenidaat bij kinderen met een aandachtstekortstoornis hyperactiviteit . Tijdschr Kindergeneeskunde . 2000;98:94–99
  14. American Academy of Pediatrics . Clinical practice guideline (Diagnosis and evaluation of the child with attention-deficit/hyperactivity disorder) . Pediatrics . 2000;105:1158–1170
  15. Diagnostic and statistical manual of mental disorders . 4th ed. Washington, DC: American Psychiatric Association; 1994; (DSM-IV)
  16. Goldman LS , Genel M , Bezman RJ , Slanetz PJ  Council on Scientific Affairs, American Medical Association . Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents . JAMA . 1998;279:1100–1107
  17. Achenbach TM . Manual for Child Behavior Checklist/4–18 and 1991 Profile . Burlington: University of Vermont Department of Psychiatry; 1991;
  18. Verhulst FC , Koot JM , van der Ende J . Handleiding voor de CBCL (Child Behaviour Checklist) . Rotterdam, Netherlands: Afd. Kinder- en Jeugdpsychiatrie, Erasmus University Medical Centre; 1996;
  19. Hurks PPM , Hendriksen JGM , Feron FJM , Jolles J , Vles JSH . Information processing in ADHD children with or without learning disabilities . In: The influence of environment, behaviour, and attention deficits on cognitive development in school-aged children . Maastricht: Maastricht University; 2003;p. 143–162 Neuropsych Publishers
  20. Vos PG . Bourdon-Vos test (Handleiding (3de herziene uitgave)–Manual for the Bourdon-Vos test) . Lisse, Netherlands: Swets en Zeitlinger; 1998;
  21. Beery KE . The Beery-Buktenica Developmental Test of Visual-Motor Integration (VMI) . Parsippany, NJ: Modern Curriculum Press; 1997;
  22. Lobaugh NJ , Caldwell CB , Black SE , Leibovitch FS , Swartz RH . Three brain SPECT region-of-interest templates in elderly people (Normative values, hemispheric asymmetries, and a comparison of single- and multihead cameras) . J Nucl Med . 2000;41:45–56
  23. Ferron J . Reconsidering the use of the general linear model with single-case data . Behav Res Methods Instrum Comput . 2002;34:324–331
  24. Gadow KD , Sverd J , Sprafkin J , Nolan EE , Grossman S . Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder . Arch Gen Psychiatry . 1999;56:330–336
  25. Stiebel V , Kemp K . Long-term methylphenidate use in the medically ill patient with organic mood syndrome . Psychosomatics . 1990;31:454–456
  26. Volkow ND , Insel TR . What are the long-term effects of methylphenidate treatment? . Biol Psychiatry . 2003;54:1307–1309
  27. Weiss G , Kruger E , Danielson U , Elman M . Long-term methylphenidate treatment of hyperkinetic children . Psychopharmacol Bull . 1974;10:34–35
  28. Weiss G , Kruger E , Danielson U , Elman M . Effect of long-term treatment of hyperactive children with methylphenidate . Can Med Assoc J . 1975;112:159–165
  29. Kuczenski R , Segal DS . Exposure of adolescent rats to oral methylphenidate (Preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine) . J Neurosci . 2002;22:7264–7271
  30. Greenhill L , Beyer DH , Finkleson J , et al.   Guidelines and algorithms for the use of methylphenidate in children with Attention-Deficit/Hyperactivity Disorder . J Atten Disord . 2002;6(Suppl. 1):S89–S100
  31. Volkow ND , Ding YS , Fowler JS , Wang GJ , Logan J , Gatley SJ , et al.   Dopamine transporters decrease with age . J Nucl Med . 1996;37:554–559
  32. Dougherty DD , Bonab AA , Spencer TJ , Rauch SL , Madras BK , Fischman AJ . Dopamine transporter density in patients with attention deficit hyperactivity disorder . Lancet . 1999;354(9196):2132–2133
  33. Krause KH , Dresel SH , Krause J , Kung HF , Tatsch K . Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder (Effects of methylphenidate as measured by single photon emission computed tomography) . Neurosci Lett . 2000;285:107–110
  34. Gainetdinov RR , Wetsel WC , Jones SR , Levin ED , Jaber M , Caron MG . Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity . Science . 1999;283(5400):397–401
  35. Sarkis EH . “Model” behavior . Science . 2000;287(5461):2160–2162
  36. Meyer P , Bohnen NI , Minoshima S , et al.   Striatal presynaptic monoaminergic vesicles are not increased in Tourette’s syndrome . Neurology . 1999;53:371–374
  37. Amen DG , Carmichael BD . High-resolution brain SPECT imaging in ADHD . Ann Clin Psychiatry . 1997;9:81–86
  38. O’Tuama LA , Treves ST . Brain single-photon emission computed tomography for behavior disorders in children . Semin Nucl Med . 1993;23:255–264

PII: S0887-8994(05)00233-X

doi: 10.1016/j.pediatrneurol.2005.04.008

Pediatric Neurology
Volume 33, Issue 3 , Pages 179-183 , September 2005