Pediatric Neurology
Volume 33, Issue 4 , Pages 255-258 , October 2005

Soluble Adhesion Molecules in Acute Disseminated Encephalomyelitis

  • Davide Martino, MD

      Affiliations

    • Department of Neuroinflammation, Institute of Neurology, University College London, U.K.
    • Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • Corresponding Author InformationCommunications should be addressed to: Dr. Martino; Department of Neurological and Psychiatric Sciences; University of Bari; Piazza Giulio Cesare; 11 70124 Bari, Italy.
    • ,
  • Joceline A. Branson, MRCPCH

      Affiliations

    • Neurosciences Unit, Great Ormond Street Hospital NHS Trust and Institute of Child Health, University College London, U.K
    • ,
  • Andrew J. Church, PhD

      Affiliations

    • Department of Neuroinflammation, Institute of Neurology, University College London, U.K.
    • ,
  • Paul M. Candler, BSc

      Affiliations

    • Department of Neuroinflammation, Institute of Neurology, University College London, U.K.
    • ,
  • Paolo Livrea, MD

      Affiliations

    • Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    • ,
  • Gavin Giovannoni, PhD

      Affiliations

    • Department of Neuroinflammation, Institute of Neurology, University College London, U.K.
    • ,
  • Russell C. Dale, MRCPCH

      Affiliations

    • Department of Neuroinflammation, Institute of Neurology, University College London, U.K.
    • Neurosciences Unit, Great Ormond Street Hospital NHS Trust and Institute of Child Health, University College London, U.K

Received 6 January 2005 ,Accepted 2 May 2005.

References 

  1. Dale RC , de Sousa C , Chong WK , Cox TC , Harding B , Neville BG . Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children . Brain . 2000;123:2407–2422
  2. Hartung HP , Archelos JJ , Zielasek J , et al.   Circulating adhesion molecules and inflammatory mediators in demyelination (A review) . Neurology . 1995;45(Suppl. 6):S22–S32
  3. Lee SJ , Benveniste EN . Adhesion molecule expression and regulation on cells of the central nervous system . J Neuroimmunol . 1999;98:77–88
  4. Hartung HP , Michels M , Reiners K , Seeldrayers P , Archelos JJ , Toyka KV . Soluble ICAM-1 serum levels in multiple sclerosis and viral encephalitis . Neurology . 1993;43:2331–2335
  5. Rieckmann P , Martin S , Weichselbraun I , et al.   Serial analysis of circulating adhesion molecules and TNF receptor in serum from patients with multiple sclerosis (cICAM-1 is an indicator for relapse) . Neurology . 1994;44:2367–2372
  6. Pohl-Koppe A , Burchett SK , Thiele EA , Hafler DA . Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis . J Neuroimmunol . 1998;91:19–27
  7. Jorens PG , VanderBorght A , Ceulemans B , et al.   Encephalomyelitis-associated antimyelin autoreactivity induced by streptococcal exotoxins . Neurology . 2000;54:1433–1441
  8. Sibson NR , Blamire AM , Bernades-Silva M , et al.   MRI detection of early endothelial activation in brain inflammation . Magn Reson Med . 2004;51:248–252
  9. Giovannoni G , Thorpe JW , Kidd D , et al.   Soluble E-selectin in multiple sclerosis (Raised concentrations in patients with primary progressive disease) . J Neurol Neurosurg Psychiatry . 1996;60:20–26
  10. Bochner BS , Klunk DA , Sterbinsky SA , Coffman RL , Schleimer RP . IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells . J Immunol . 1995;154:799–803
  11. Oh JW , Van Wagoner NJ , Rose-John S , Benveniste EN . Role of IL-6 and the soluble IL-6 receptor in inhibition of VCAM-1 gene expression . J Immunol . 1998;161:4992–4999
  12. Dale RC , Morovat A . Interleukin-6 and oligoclonal IgG synthesis in children with acute disseminated encephalomyelitis . Neuropediatrics . 2003;34:141–145

PII: S0887-8994(05)00259-6

doi: 10.1016/j.pediatrneurol.2005.05.006

Pediatric Neurology
Volume 33, Issue 4 , Pages 255-258 , October 2005

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