Pediatric Neurology
Volume 34, Issue 1 , Pages 20-24 , January 2006

New Proteins Configure a Brain Drug Resistance Map in Tuberous Sclerosis

Presented at the TSC International Research Conference 2004, Cambridge, UK, September 16-18, 2004.

  • Alberto J. Lazarowski, PhD

      Affiliations

    • Clinical Biochemistry Department, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires (UBA)
    • Institute of Cell Biology and Neurobiology “Dr. E de Robertis”, Facultad de Medicina, Universidad de Buenos Aires (UBA)
    • Corresponding Author InformationCommunications should be addressed to: Dr. Lazarowski; Caseros 1944, #9B; (1152) Buenos Aires, Argentina
    • ,
  • Fabiana J. Lubieniecki, MD

      Affiliations

    • Laboratory of Neuropathology, Hospital Nacional de Pediatria “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
    • ,
  • Sandra A. Camarero, BS

      Affiliations

    • Laboratory of Neuropathology, Hospital Nacional de Pediatria “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
    • ,
  • Hugo H. Pomata, MD

      Affiliations

    • Neurosurgery Department, Hospital Nacional de Pediatria “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
    • ,
  • Marcelo A. Bartuluchi, MD

      Affiliations

    • Neurosurgery Department, Hospital Nacional de Pediatria “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
    • ,
  • Gustavo Sevlever, MD, PhD

      Affiliations

    • Laboratory of Neuropathology, Instituto de Investigaciones Neurologicas “Dr. Raul Carrea” FLENI, Buenos Aires, Argentina
    • ,
  • Ana Lía Taratuto, MD, PhD

      Affiliations

    • Laboratory of Neuropathology, Hospital Nacional de Pediatria “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
    • Laboratory of Neuropathology, Instituto de Investigaciones Neurologicas “Dr. Raul Carrea” FLENI, Buenos Aires, Argentina

Received 18 January 2005 ,Accepted 13 June 2005.

References 

  1. Avellino AM , Berger MS , Rostomily RC , Shaw CM , Ojemann GA . Surgical management and seizure outcome in patients with tuberous sclerosis . J Neurosurg . 1997;87:391–396
  2. Crino PB , Miyata H , Vinters HV . Neurodevelopmental disorders as a cause of seizures (Neuropathologic, genetic, and mechanistic considerations) . Brain Pathol . 2002;12:212–233
  3. Borst P , Elferink RO . Mammalian ABC transporters in health and disease . Annu Rev Biochem . 2002;71:537–592
  4. Lazarowski A , Lubieniecki F , Camarero S , et al.   Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy . Pediatr Neurol . 2004;30:102–106
  5. Lazarowski A , Sevlever G , Taratuto A , Massaro M , Rabinowicz A . Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy . Ped Neurol . 1999;21:731–734
  6. Sarkadi B , Ozvegy-Laczka C , Nemet K , Varadi A . ABCG2 a transporter for all seasons [Review] . FEBS Lett . 2004;567:116–120
  7. Scheffer GL , Schroeijers AB , Izquierdo MA , Wiemer EA , Scheper RJ . Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer . Curr Opin Oncol . 2000;12:550–556
  8. Sisodiya SM , Martinian L , Scheffer GL , et al.   Major vault protein, a marker of drug resistance, is upregulated in refractory epilepsy . Epilepsia . 2003;44:1388–1396
  9. Zhenbao Yu , Fotouhi-Ardakani N , Wu L , et al.   PTEN associates with the vault particles in HeLa cells . J Biol Chem . 2002;277:40247–40252
  10. van Vliet EA , Aronica E , Redeker S , Gorter JA . Expression and cellular distribution of major vault protein (A putative marker for pharmacoresistance in a rat model for temporal lobe epilepsy) . Epilepsia . 2004;45:1506–1516
  11. Sisodiya SM , Lin WR , Harding BN , Squier MV , Thom M . Drug resistance in epilepsy (Expression of drug resistance proteins in common cause of refractory epilepsy) . Brain . 2002;125:22–31
  12. Lazarowski A , Massaro M , Schteinschnaider A , Intruvini S , Sevlever G , Rabinowicz A . Neuronal MDR-1 gene expression and persistent low levels of anticonvulsants in a child with refractory epilepsy . Ther Drug Monit . 2004;26:44–46

PII: S0887-8994(05)00341-3

doi: 10.1016/j.pediatrneurol.2005.06.008

Pediatric Neurology
Volume 34, Issue 1 , Pages 20-24 , January 2006

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