Pediatric Neurology
Volume 36, Issue 2 , Pages 73-80 , February 2007

Hemorrhagic Stroke in Children

  • Lori C. Jordan, MD

      Affiliations

    • Corresponding Author InformationCommunications should be addressed to: Dr. Jordan; Johns Hopkins University School of Medicine; 200 N. Wolfe St.; Suite 2158; Baltimore, MD 21287.
  • ,
  • Argye E. Hillis, MD

Received 7 August 2006 ,Accepted 28 September 2006.

References 

  1. Lynch JK, Hirtz DG, DeVeber G, Nelson KB. Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke. Pediatrics. 2002;109:116–123
  2. National Center for Health Statistics. Deaths, percentage of total deaths, and death rates for the 10 leading causes of death in selected age groups, by race and sex: United States, 2002. 2005;Updated November; Available at: www.cdc.gov/nchs/data/nvsr/nvsr53/nvsr53_17.pdf. Accessed June 16, 2006.
  3. Heideman RL, Packer RJ, Albright LA, Freeman CR, Rorke LB. Tumors of the central nervous system. In:  Pizzo PA,  Paplack DG editor. Principles and practice of pediatric oncology. 3rd ed.. Philadelphia: Lippincott; 1997;p. 633–697
  4. Fullerton HJ, Wu YW, Zhao S, Johnston SC. Risk of stroke in children: Ethnic and gender disparities. Neurology. 2003;61:189–194
  5. Blom I, De Schryver EL, Kappelle LJ, Rinkel GJ, Jennekens-Schinkel A, Peters AC. Prognosis of haemorrhagic stroke in childhood: A long-term follow-up study. Dev Med Child Neurol. 2003;45:233–239
  6. Lynch JK, Han CJ. Pediatric stroke: What do we know and what do we need to know?. Semin Neurol. 2005;25:410–423
  7. Huang J, McGirt MJ, Gailloud P, Tamargo RJ. Intracranial aneurysms in the pediatric population: Case series and literature review. Surg Neurol. 2005;63:424–432
  8. Sanai N, Quinones-Hinojosa A, Gupta NM, et al. Pediatric intracranial aneurysms: Durability of treatment following microsurgical and endovascular management. J Neurosurg. 2006;104(2 Suppl):82–89
  9. Broderick J, Talbot GT, Prenger E, Leach A, Brott T. Stroke in children within a major metropolitan area: The surprising importance of intracerebral hemorrhage. J Child Neurol. 1993;8:250–255
  10. Pediatric Stroke Working Group. Stroke in childhood: Clinical guidelines for diagnosis, management and rehabilitation. 2004;Available at: http://www.rcplondon.ac.uk/pubs/books/childstroke/childstroke_guidelines.pdf. Accessed July 1, 2006.
  11. Monagle P, Chan A, Massicotte P, Chalmers E, Michelson AD. Antithrombotic therapy in children: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3 Suppl):645S–687S
  12. Giroud M, Lemesle M, Madinier G, Manceau E, Osseby GV, Dumas R. Stroke in children under 16 years of age: Clinical and etiological difference with adults. Acta Neurol Scand. 1997;96:401–406
  13. Foulkes MA, Wolf PA, Price TR, Mohr JP, Hier DB. The Stroke Data Bank: Design, methods, and baseline characteristics. Stroke. 1988;19:547–554
  14. Broderick JP, Adams HP, Barsan W, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke. 1999;30:905–915
  15. Al-Jarallah A, Al-Rifai MT, Riela AR, Roach ES. Nontraumatic brain hemorrhage in children: Etiology and presentation. J Child Neurol. 2000;15:284–289
  16. Meyer-Heim AD, Boltshauser E. Spontaneous intracranial haemorrhage in children: Aetiology, presentation and outcome. Brain Dev. 2003;25:416–421
  17. Sandberg DI, Lamberti-Pasculli M, Drake JM, Humphreys RP, Rutka JT. Spontaneous intraparenchymal hemorrhage in full-term neonates. Neurosurgery. 2001;48:1042–1048
  18. Duhem R, Vinchon M, Leblond P, Soto-Ares G, Dhellemmes P. Cavernous malformations after cerebral irradiation during childhood: Report of nine cases. Childs Nerv Syst. 2005;21:922–925
  19. Chung B, Wong V. Pediatric stroke among Hong Kong Chinese subjects. Pediatrics. 2004;114:e206–e212
  20. Weber AL. History of head and neck radiology: Past, present, and future. Radiology. 2001;218:15–24
  21. Lanthier S, Carmant L, David M, Larbrisseau A, de Veber G. Stroke in children: The coexistence of multiple risk factors predicts poor outcome. Neurology. 2000;54:371–378
  22. Livingston JH, Brown JK. Intracerebral haemorrhage after the neonatal period. Arch Dis Child. 1986;61:538–544
  23. Jarjour IT, Ahdab-Barmada M. Cerebrovascular lesions in infants and children dying after extracorporeal membrane oxygenation. Pediatr Neurol. 1994;10:13–19
  24. Strouse JJ, Hubert HL, Debaun MR, Jordan LC, Casella JF. Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids. Pediatrics. 2006;118:1916–1924
  25. Kyrnetskiy EE, Kun LE, Boop FA, Sanford RA, Khan RB. Types, causes, and outcome of intracranial hemorrhage in children with cancer. J Neurosurg. 2005;102(Suppl):31–35
  26. Lilleyman JS Paediatric Haematology Forum of the British Society for Haematology. Intracranial haemorrhage in idiopathic thrombocytopenic purpura. Arch Dis Child. 1994;71:251–253
  27. Butros LJ, Bussel JB. Intracranial hemorrhage in immune thrombocytopenic purpura: A retrospective analysis. J Pediatr Hematol Oncol. 2003;25:660–664
  28. Klinge J, Auberger K, Auerswald G, Brackmann HH, Mauz-Korholz C, Kreuz W. Prevalence and outcome of intracranial haemorrhage in haemophiliacs—a survey of the paediatric group of the German Society of Thrombosis and Haemostasis (GTH). Eur J Pediatr. 1999;158(Suppl 3):S162–S165
  29. Revel-Vilk S, Golomb MR, Achonu C, et al. Effect of intracranial bleeds on the health and quality of life of boys with hemophilia. J Pediatr. 2004;144:490–495
  30. Yoffe G, Buchanan GR. Intracranial hemorrhage in newborn and young infants with hemophilia. J Pediatr. 1988;113:333–336
  31. Martinowitz U, Heim M, Tadmor R, et al. Intracranial hemorrhage in patients with hemophilia. Neurosurgery. 1986;18:538–541
  32. Earley CJ, Kittner SJ, Feeser BR, et al. Stroke in children and sickle-cell disease: Baltimore-Washington Cooperative Young Stroke Study. Neurology. 1998;51:169–176
  33. Ohene-Frempong K, Weiner SJ, Sleeper LA, et al. Cerebrovascular accidents in sickle cell disease: Rates and risk factors. Blood. 1998;91:288–294
  34. Diggs LW, Brookoff D. Multiple cerebral aneurysms in patients with sickle cell disease. South Med J. 1993;86:377–379
  35. Dobson SR, Holden KR, Nietert PJ, et al. Moyamoya syndrome in childhood sickle cell disease: A predictive factor for recurrent cerebrovascular events. Blood. 2002;99:3144–3150
  36. Royal JE, Seeler RA. Hypertension, convulsions, and cerebral haemorrhage in sickle-cell anaemia patients after blood-transfusions. Lancet. 1978;2:1207
  37. Henderson JN, Noetzel MJ, McKinstry RC, White DA, Armstrong M, DeBaun MR. Reversible posterior leukoencephalopathy syndrome and silent cerebral infarcts are associated with severe acute chest syndrome in children with sickle cell disease. Blood. 2003;101:415–419
  38. Atweh GF, DeSimone J, Saunthararajah Y, et al. Hemoglobinopathies. Hematology Am Soc Hematol Educ Program. 2003;14–39
  39. Kidwell CS, Chalela JA, Saver JL, et al. Comparison of MRI and CT for detection of acute intracerebral hemorrhage. JAMA. 2004;292:1823–1830
  40. Liu AC, Segaren N, Cox TS, et al. Is there a role for magnetic resonance imaging in the evaluation of non-traumatic intraparenchymal haemorrhage in children?. Pediatr Radiol. 2006;36:940–946
  41. Lin CL, Loh JK, Kwan AL, Howng SL. Spontaneous intracerebral hemorrhage in children. Kaohsiung J Med Sci. 1999;15:146–151
  42. Burger IM, Murphy KJ, Jordan LC, Tamargo RJ, Gailloud P. Safety of cerebral digital subtraction angiography (DSA) in children: Complication rate analysis in 241 consecutive diagnostic angiograms. Stroke. 2006;37:2535–2539
  43. Schwarz S, Hafner K, Aschoff A, Schwab S. Incidence and prognostic significance of fever following intracerebral hemorrhage. Neurology. 2000;54:354–361
  44. Gebel JM, Jauch EC, Brott TG, et al. Natural history of perihematomal edema in patients with hyperacute spontaneous intracerebral hemorrhage. Stroke. 2002;33:2631–2635
  45. Poungvarin N, Bhoopat W, Viriyavejakul A, et al. Effects of dexamethasone in primary supratentorial intracerebral hemorrhage. N Engl J Med. 1987;316:1229–1233
  46. Tellez H, Bauer RB. Dexamethasone as treatment in cerebrovascular disease (1. A controlled study in intracerebral hemorrhage). Stroke. 1973;4:541–546
  47. Passero S, Ciacci G, Ulivelli M. The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage. Neurology. 2003;61:1351–1356
  48. Weir CJ, Murray GD, Dyker AG, Lees KR. Is hyperglycaemia an independent predictor of poor outcome after acute stroke? (Results of a long-term follow up study). BMJ. 1997;314:1303–1306
  49. Clatterbuck RE, Hsu FP, Spetzler RF. Supratentorial arteriovenous malformations. Neurosurgery. 2005;57(1 Suppl):164–167
  50. Shin M, Kawamoto S, Kurita H, et al. Retrospective analysis of a 10-year experience of stereotactic radio surgery for arteriovenous malformations in children and adolescents. J Neurosurg. 2002;97:779–784
  51. Maruyama K, Kawahara N, Shin M, et al. The risk of hemorrhage after radiosurgery for cerebral arteriovenous malformations. N Engl J Med. 2005;352:146–153
  52. Levy EI, Niranjan A, Thompson TP, et al. Radiosurgery for childhood intracranial arteriovenous malformations. Neurosurgery. 2000;47:834–841
  53. Cohen-Gadol AA, Pollock BE. Radiosurgery for arteriovenous malformations in children. J Neurosurg. 2006;104(6 Suppl):388–391
  54. Choi JH, Mast H, Sciacca RR, et al. Clinical outcome after first and recurrent hemorrhage in patients with untreated brain arteriovenous malformation. Stroke. 2006;37:1243–1247
  55. Stapf C, Mast H, Sciacca RR, et al. The New York Islands AVM Study: Design, study progress, and initial results. Stroke. 2003;34:e29–e33
  56. Vespa P, McArthur D, Miller C, et al. Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduction of hemorrhage volume and neurological improvement. Neurocrit Care. 2005;2:274–281
  57. Cho DY, Chen CC, Chang CS, Lee WY, Tso M. Endoscopic surgery for spontaneous basal ganglia hemorrhage: Comparing endoscopic surgery, stereotactic aspiration, and craniotomy in noncomatose patients. Surg Neurol. 2006;65:547–555
  58. Mayer SA, Brun NC, Begtrup K, et al. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2005;352:777–785
  59. Barrett RJ, Hussain R, Coplin WM, et al. Frameless stereotactic aspiration and thrombolysis of spontaneous intracerebral hemorrhage. Neurocrit Care. 2005;3:237–245
  60. Naff NJ, Hanley DF, Keyl PM, et al. Intraventricular thrombolysis speeds blood clot resolution: Results of a pilot, prospective, randomized, double-blind, controlled trial. Neurosurgery. 2004;54:577–583
  61. Mendelow AD, Gregson BA, Fernandes HM, et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): A randomised trial. Lancet. 2005;365:387–397
  62. Rabinstein AA, Atkinson JL, Wijdicks EF. Emergency craniotomy in patients worsening due to expanded cerebral hematoma: To what purpose?. Neurology. 2002;58:1367–1372
  63. Mathew P, Teasdale G, Bannan A, Oluoch-Olunya D. Neurosurgical management of cerebellar haematoma and infarct. J Neurol Neurosurg Psychiatry. 1995;59:287–292
  64. Mayer SA, Rincon F. Treatment of intracerebral haemorrhage. Lancet Neurol. 2005;4:662–672
  65. O’Connell KA, Wood JJ, Wise RP, Lozier JN, Braun MM. Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA. 2006;295:293–298
  66. Gabis LV, Yangala R, Lenn NJ. Time lag to diagnosis of stroke in children. Pediatrics. 2002;110:924–928
  67. Ganesan V, Hogan A, Shack N, Gordon A, Isaacs E, Kirkham FJ. Outcome after ischaemic stroke in childhood. Dev Med Child Neurol. 2000;42:455–461
  68. De Schryver EL, Kappelle LJ, Jennekens-Schinkel A, Boudewyn Peters AC. Prognosis of ischemic stroke in childhood: A long-term follow-up study. Dev Med Child Neurol. 2000;42:313–318
  69. Hetherington R, Tuff L, Anderson P, Miles B, deVeber G. Short-term intellectual outcome after arterial ischemic stroke and sinovenous thrombosis in childhood and infancy. J Child Neurol. 2005;20:553–559
  70. Broderick JP, Brott TG, Duldner JE, Tomsick T, Huster G. Volume of intracerebral hemorrhage: A powerful and easy-to-use predictor of 30-day mortality. Stroke. 1993;24:987–993
  71. Hemphill JC, Bonovich DC, Besmertis L, Manley GT, Johnston SC. The ICH score: A simple, reliable grading scale for intracerebral hemorrhage. Stroke. 2001;32:891–897
  72. Fullerton HJ, Chetkovich DM, Wu YW, Smith WS, Johnston SC. Deaths from stroke in US children, 1979 to 1998. Neurology. 2002;59:34–39
  73. Visudhiphan P, Chiemchanya S, Wattanasirichaigoon D. Strokes in Thai children: Etiology and outcome. Southeast Asian J Trop Med Public Health. 1996;27:801–805
  74. Nelson MD, Maeder MA, Usner D, et al. Prevalence and incidence of intracranial haemorrhage in a population of children with haemophilia (The Hemophilia Growth and Development Study). Haemophilia. 1999;5:306–312
  75. Fullerton HJ, Achrol AS, Johnston SC, et al. Long-term hemorrhage risk in children versus adults with brain arteriovenous malformations. Stroke. 2005;36:2099–2104
  76. Hanley DF, Hacke W. Critical care and emergency medicine neurology. Stroke. 2004;35:365–366
  77. Rincon F, Mayer SA. Novel therapies for intracerebral hemorrhage. Curr Opin Crit Care. 2004;10:94–100
  78. Schoenberg BS, Mellinger JF, Schoenberg DG. Cerebrovascular disease in infants and children: A study of incidence, clinical features, and survival. Neurology. 1978;28:763–768
  79. Zhu XL, Chan MS, Poon WS. Spontaneous intracranial hemorrhage: Which patients need diagnostic cerebral angiography? (A prospective study of 206 cases and review of the literature). Stroke. 1997;28:1406–1409
  80. Eeg-Olofsson O, Ringheim Y. Stroke in children: Clinical characteristics and prognosis. Acta Paediatr Scand. 1983;72:391–395
  81. Beran-Koehn MA, Brown RD, Mellinger JF, Christianson TJ, O’Fallon WM. Cerebrovascular disease in children: Incidence, etiology and outcome. Neurology. 1999;52(Suppl 2):A43–A44
  82. Zahuranec DB, Brown DL, Lisabeth LD, Morgenstern LB. Is it time for a large, collaborative study of pediatric stroke?. Stroke. 2005;36:1825–1829

PII: S0887-8994(06)00625-4

doi: 10.1016/j.pediatrneurol.2006.09.017

Pediatric Neurology
Volume 36, Issue 2 , Pages 73-80 , February 2007