« Previous
Next »
Pediatric Neurology
Volume 38, Issue 3
, Pages 151-162
, March 2008
Choosing the Correct Antiepileptic Drugs: From Animal Studies to the Clinic
References
- . A new series of anticonvulsant drugs tested by experiments on animals. Arch Neurol Psychiatry. 1938;39:1003–1015
- . Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia. 1981;22:249–260
- . Cortical cellular phenomena in experimental epilepsy: Ictal manifestations. Exp Neurol. 1964;25:305–326
- . Cortical cellular phenomena in experimental epilepsy: Interictal manifestations. Exp Neurol. 1964;80:286–304
- . The neurobiology of antiepileptic drugs. Nat Rev Neurosci. 2004;5:553–564
- . Mechanism of action of the anticonvulsant felbamate: Opposing effects on N-methyl-d-aspartate and GABAA receptors. Ann Neurol. 1994;35:229–234
- . An overview of the preclinical aspects of topiramate: Pharmacology, pharmacokinetics, and mechanism of action. Epilepsia. 2000;41(Suppl. 1):S3–S9
- . Preferential action of gabapentin and pregabalin at P/Q-type voltage-sensitive calcium channels: Inhibition of K+-evoked [3H]-norepinephrine release from rat neocortical slices. Synapse. 2002;45:171–190
- . Pharmacological upregulation of H-channels reduces the excitability of pyramidal neuron dendrites. Nat Neurosci. 2002;5:767–774
- . Gabapentin increases the hyperpolarization-activated cation current Ih in rat CA1 pyramidal cells. Epilepsia. 2003;44:150–156
- The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. Br J Pharmacol. 2002;136:659–672
- The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci USA. 2004;101:9861–9866
- . Effects of seizures on developmental processes in the immature brain. Lancet Neurol. 2006;5:1055–1063
- . The multiple facets of gamma-aminobutyric acid dysfunction in epilepsy. Curr Opin Neurol. 2005;18:141–145
- . Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. Eur J Neurosci. 2004;19:590–600
- . Developmental seizures induced by common early-life insults: Short- and long-term effects on seizure susceptibility. Ment Retard Dev Disabil Res Rev. 2000;6:253–257
- Early development of neuronal activity in the primate hippocampus in utero. J Neurosci. 2001;21:9770–9781
- . Giant synaptic potentials in immature rat CA3 hippocampal neurones. J Physiol (Lond). 1989;416:303–325
- . Excitatory actions of GABA during development: The nature of the nurture. Nat Rev Neurosci. 2002;3:728–739
- . Transition from interictal to ictal activity in limbic networks in vitro. J Neurosci. 2003;23:7873–7880
- . Late maturation of GABA(B) synaptic transmission in area CA1 of the rat hippocampus. Neuropharmacology. 1999;38:1733–1742
- . NR2A subunit composition shortens NMDA receptor synaptic currents in developing neocortex. J Neurosci. 1997;17:2469–2476
- Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med. 1999;341:485–489
- NKCC1 transporter facilitates seizures in the developing brain. Nat Med. 2005;11:1205–1213
- . Models for generalized seizures. Clin Neurophysiol. 2004;57(Suppl):415–424
- . A role for GABAB receptors in excitation and inhibition of thalamocortical cells. TINS. 1991;14:16–21
- . Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice. J Neurosci. 2004;24:5249–5257
- . Increased number of GABAB receptors in the lethargic (lh/lh) mouse model of absence epilepsy. Brain Res. 1993;608:101–106
- . Basic mechanisms of generalized absence seizures. Ann Neurol. 1995;37:146–157
- The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice. Science. 1992;257:398–401
- . Clonazepam suppresses GABAB-mediated inhibition in thalamic relay neurons through effects in nucleus reticularis. J Neurophysiol. 1994;71:2576–2581
- . Discovery and preclinical development of antiepileptic drugs. In: Levy RH, Mattson RH, Meldrum BS, Perucca E editor. Antiepileptic drugs. 5th ed.. Philadelphia: Lippincott Williams & Williams; 2002;p. 36–48
- . Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia. 1997;38(Suppl. 1):S9–S17
- . The early identification of anticonvulsant activity: Role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models. Ital J Neurol Sci. 1995;16:73–77
- . The pharmacologic basis of antiepileptic drug action. Epilepsia. 1999;40:1471–1483
- . Antiepileptic drug development: II (Anticonvulsant drug screening). Epilepsia. 1978;19:409–428
- . Antiepileptic drug development: I (History and a program for progress). Epilepsia. 1978;19:393–408
- . Screening of new compounds and the role of the pharmaceutical industry. In: Engel J, Pedley TA editor. Epilepsy: A comprehensive textbook. Philadelphia: Lippincott-Raven; 1997;p. 1417–1434
- . Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. Eur J Pharmacol. 1998;353:191–206
- . Antiepileptogenic effects of the novel anticonvulsant levetiracetam (UCB L059) in the kindling model of temporal lobe epilepsy. J Pharmacol Exp Ther. 1998;284:474–479
- . Pharmacological models of generalized absence seizures in rodents. J Neural Transm. 1992;35(Suppl):7–19
- Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: Summary of the NIH/NINDS/AES Models II Workshop. Epilepsia. 2003;44:1472–1478
- . Kindling model of epilepsy. Adv Neurol. 1986;44:303–318
- . The kindling model of epilepsy: A review. Prog Neurobiol. 1980;15:139–159
- . Development of new pharmacological agents for epilepsy: Lessons from the kindling model. Epilepsia. 1989;30(Suppl. 1):S13–S18
- . Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model. Epilepsy Res. 2003;53:95–106
- . Effects of valproate, phenytoin, and zonisamide on clonic and tonic seizures induced by acute and repeated exposure of mice to flurothyl. Physiol Behav. 2003;78:465–469
- . Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs (A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy). Epilepsy Res. 2002;50:105–123
- . Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 1993;638:36–44
- . The effect of progesterone on kindling: A developmental study. Brain Res. 1984;318:45–53
- . Posture. In: Whishaw IQ, Kolb B editor. The behavior of the laboratory rat (A handbook with tests). Oxford: Oxford University Press; 2005;p. 121–128
- . Locomotion. In: Whishaw IQ, Kolb B editor. The behavior of the laboratory rat (A handbook with tests). Oxford: Oxford University Press; 2005;p. 150–161
- Predictors of lamotrigine-associated rash. Epilepsia. 2006;47:318–322
- . Gabapentin toxicity in children manifesting as behavioral changes. Epilepsia. 1995;36:1203–1205
- . Efficacy of gabapentin therapy in children with refractory partial seizures. J Pediatr. 1996;128:829–833
- . Attention deficit disorder and epilepsy. Pediatr Neurol. 2005;32:1–10
- . Valproic acid hepatic fatalities: A retrospective review. Neurology. 1987;37:379–385
- . Valproic acid hepatic fatalities: US experience since 1984. Neurology. 1989;39:201–207
- . Anticonvulsant action of gabapentin during postnatal development in rats. Epilepsia. 1997;38:893–896
- . Clobazam exerts an anticonvulsant action in immature rats. Physiol Res. 1998;47:301–305
- . Does vigabatrin possess an anticonvulsant action against pentylenetetrazol-induced seizures in developing rats?. Physiol Res. 2002;51:363–370
- . Infantile spasms: Criteria for an animal model. Int Rev Neurobiol. 2002;49:391–411
- Practice parameter: Medical treatment of infantile spasms: Report of the American Academy of Neurology and the Child Neurology Society. Neurology. 2004;62:1668–1681
- . ACTH and prednisone in childhood seizure disorders. Neurology. 1983;33:966–970
- . Quantitative growth and development of human brain. Arch Dis Child. 1973;48:757–767
- . NBQX blocks acute and late epileptogenic effects of perinatal hypoxia. Epilepsia. 1995;36:966–972
- . NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury. Epilepsia. 2004;45:569–575
- . Topiramate blocks perinatal hypoxia-induced seizures in rat pups. Ann Neurol. 2001;50:366–372
- . Febrile seizures in the immature rat model modify neuronal excitability long-term. Nat Med. 1999;5:888–894
- . Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term. Ann Neurol. 2000;47:336–344
- . Seizure-induced neuronal injury: Vulnerability to febrile seizures in an immature rat model. J Neurosci. 1998;18:4285–4294
- . Temporal lobe epilepsy after experimental prolonged febrile seizures: Prospective analysis. Brain. 2006;129:911–922
- . Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. J Neurosci. 2002;22:4591–4599
- . Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. Hippocampus. 2004;13:399–412
- . Serial MRI after experimental febrile seizures: Altered T2 signal without neuronal death. Ann Neurol. 2004;56:709–714
- . Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis. 2005;19:200–207
- . Effects of anticonvulsants on hyperthermia-induced seizures in the rat pup. Epilepsia. 1984;25:96–99
- . Complex febrile seizures—An experimental model in immature rodents. In: Pitkänen A, Schwartzkroin PA, Moshé S editor. Models of seizures and epilepsy. Burlington, MA: Elsevier; 2006;p. 333–340
- . Measurement of brain excitability by use of hexaflurodiethyl ether (Indoklon). J Pharmacol Exp Ther. 1960;129:445–453
- . Developmental aspects of experimental generalized seizures induced by pentylenetetrazol, bicuculline and flurothyl. In: Malafosse A, Genton P, Hirsch E, Marescaux C, Broglin D, Bernasconi R editor. Idiopathic generalized epilepsies. London: John Libbey; 1994;p. 51–64
- . Flurothyl status epilepticus in developing rats: Behavioral, electrographic, histological and electrophysiological studies. Dev Brain Res. 1999;116:59–68
- . Age-related differences in seizure susceptibility to flurothyl. Dev Brain Res. 1988;39:295–297
- . Ontogeny of flurothyl-induced seizures: A behavioral and EEG electroencephalographic analysis. Epilepsia. 1993;34(Suppl. 6):63
- Consequences of recurrent seizures during early brain development. Neuroscience. 1999;92:1443–1454
- . Lack of cell loss following recurrent neonatal seizures. Brain Res Dev Brain Res. 2002;135:101–104
- . Consequences of neonatal seizures in the rat: Morphological and behavioral effects. Ann Neurol. 1998;44:845–857
- Long-term effects of neonatal seizures: A behavioral, electrophysiological, and histological study. Brain Res Dev Brain Res. 1999;118:99–107
- Reduced neurogenesis after neonatal seizures. J Neurosci. 2001;21:2094–2103
- . Effects of neonatal status epilepticus on rat brain development. Neurology. 1976;26:975–986
- . Neonatal seizures and brain growth. Neuropaediatrie. 1978;9:213–228
- . Vulnerability of developing rat brain to electroconvulsive seizures. Arch Neurol. 1973;29:38–45
- Recurrent seizures in immature rats: Effect on auditory and visual discrimination. Dev Brain Res. 1996;95:283–292
- . Long-term effects of seizures in neonatal rats on spatial learning ability and N-methyl-d-aspartate receptor expression in the brain. Brain Res Dev Brain Res. 2004;152:137–142
- Timing of cognitive deficits following neonatal seizures: Relationship to histological changes in the hippocampus. Brain Res Dev Brain Res. 2001;131:73–83
- . Neonatal seizures induced persistent changes in intrinsic properties of CA1 rat hippocampal cells. Ann Neurol. 2000;47:729–738
- . Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures. Eur J Neurosci. 2006;23:1559–1566
- . A model of atypical absence seizures: EEG, pharmacology, and developmental characterization. Neurology. 2001;56:341–349
- . A chronic model of atypical absence seizures: Studies of developmental and gender sensitivity. Epilepsy Res. 2002;48:111–119
- . Learning and memory impairment in rats with chronic atypical absence seizures. Exp Neurol. 2004;190:328–336
- Daily rhythms of seizure activity and behavior in a model of atypical absence epilepsy. Epilepsy Behav. 2006;9:564–572
- . GABAB receptor antagonism abolishes the learning impairments in rats with chronic atypical absence seizures. Eur J Pharmacol. 2006;541:64–72
- . Models of pediatric epilepsies: Strategies and opportunities. Epilepsia. 2006;47:1407–1414
- . Age-specific N-methyl-d-aspartate-induced seizures: Perspectives for the West syndrome model. Epilepsia. 1999;40:1357–1369
- . N-methyl-d-aspartate (NMDA)-induced seizures in developing rats. Brain Res Dev Brain Res. 1992;65:185–189
- . Model of infantile spasms induced by N-methyl-d-aspartic acid in prenatally impaired brain. Ann Neurol. 2007;61:109–119
- . NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility. Epilepsy Res. 2003;53:129–137
- . Pathophysiology of massive infantile spasms: Perspective on the putative role of brain adrenal axis. Ann Neurol. 1993;33:231–236
- . Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: Possible implications for behaviour. Neuroscience. 2001;104:71–79
- . Models for infantile spasms: An arduous journey to the Holy Grail. Ann Neurol. 2007;61:89–91
PII: S0887-8994(07)00459-6
doi: 10.1016/j.pediatrneurol.2007.09.008
© 2008 Elsevier Inc. All rights reserved.
« Previous
Next »
Pediatric Neurology
Volume 38, Issue 3
, Pages 151-162
, March 2008
