Arterial Ischemic Stroke: Experience in Chinese Children

Shi, Kai-Li; Wang, Jian-Jun; Li, Jiu-Wei; Jiang, Li-Qiong; Mix, Eilhard; Fang, Fang; Wu, Hu-Sheng; Jin, Xiao; Jing, Hong; Zou, Li-Ping

doi:10.1016/j.pediatrneurol.2007.11.002

« Previous Next »Pediatric Neurology
Volume 38, Issue 3 , Pages 186-190, March 2008

Arterial Ischemic Stroke: Experience in Chinese Children

Kai-Li Shi, MD
- Department of Neurology, Beijing Children’s Hospital, The Capital Medical University, Beijing, China
Jian-Jun Wang, MD
- Department of Neurology, Beijing Children’s Hospital, The Capital Medical University, Beijing, China
Jiu-Wei Li, MD
- Department of Neurology, Beijing Children’s Hospital, The Capital Medical University, Beijing, China
Li-Qiong Jiang, MD
- Department of Neurology, Beijing Children’s Hospital, The Capital Medical University, Beijing, China
Eilhard Mix, MD, PhD
- Department of Neurology, University of Rostock, Rostock, Germany.
Fang Fang, MD
- Department of Neurology, Beijing Children’s Hospital, The Capital Medical University, Beijing, China
Hu-Sheng Wu, MD
- Department of Neurology, Beijing Children’s Hospital, The Capital Medical University, Beijing, China
Xiao Jin, MD
- Department of Neurology, Beijing Children’s Hospital, The Capital Medical University, Beijing, China
Hong Jing, MD
- Department of Neurology, Beijing Children’s Hospital, The Capital Medical University, Beijing, China
Li-Ping Zou, MD, PhD
- Department of Neurology, Beijing Children’s Hospital, The Capital Medical University, Beijing, China
- Communications should be addressed to: Dr. Zou; Department of Neurology; Beijing Children’s Hospital; The Capital Medical University; Beijing 100045, China.

Received 5 July 2007; accepted 12 November 2007.

The aim of this study was to review cases of pediatric arterial ischemic stroke among Chinese subjects and thereby evaluate risk factors, clinical and neuroimaging features, and treatment, to establish a reasonable guideline for assessment and management of the disease. Between 1996 and 2006, 157 children (male:female ratio, 1.4:1) with arterial ischemic stroke were identified at Beijing Children’s Hospital. The median age at stroke was 32 months (range, 4-192). Among patients with determined etiology, infections (12.1%), moyamoya disease (12.1%), and trauma (10.8%) were the most common. In 51 patients, there were no obvious risk factors (32.5%). Hemiplegia was the most common presenting feature (81.5%). The region of left middle cerebral artery was most frequently affected (36.3%), followed by the right middle cerebral artery (29.9%). Of the 157 patients, 56 were treated by intravenous thrombolytic agents (35.7%), all but one of them successfully (the one exception involving hemorrhagic complication). Randomized controlled trials are needed to establish primary prevention, acute treatment, and secondary prevention of pediatric ischemic stroke.