Pediatric Neurology
Volume 38, Issue 3 , Pages 177-180 , March 2008

Intravenous Levetiracetam in Children With Epilepsy

This paper was presented as an abstract at the American Epilepsy Society Meeting in Philadelphia, December 3, 2007.

Received 14 August 2007 ,Accepted 6 November 2007.

References 

  1. French J, Edrich P, Cramer JA. A systemic review of the safety profile of levetiracetam: A new antiepileptic drug. Epilepsy Res. 2001;47:77–90
  2. Patsalos PN. Clinical pharmacokinetics of levetiracetam. Clin Pharmacokinet. 2004;43:707–724
  3. Khurana DS, Kothare SV, Valencia I, Melvin JM, Legido A. Levetiracetam monotherapy in children with epilepsy. Pediatr Neurol. 2007;36:227–230
  4. Ramael S, Daoust A, Otoul C, et al. Levetiracetam intravenous infusion: A randomized, placebo-controlled safety and pharmacokinetic study. Epilepsia. 2006;47:1128–1135
  5. Ramael S, De Smedt F, Toublanc N, et al. Single dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multi-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion compared with placebo in healthy subjects. Clin Ther. 2006;28:734–744
  6. Baulac M, Brodie MJ, Elger CE, et al. Levetiracetem intravenous infusion as an alternative to oral dosing in patients with partial-onset seizures. Epilepsia. 2007;48:589–592
  7. Schulze-Bonhage A, Hefft S, Oehl B. Termination of complex partial status epilepticus by intravenous levetiracetam—A case report. J Neurol Neurosurg Psychaitry [published online 12 March 2007; doi:10.1136/jnnp.2006.113951; Epub ahead of print].
  8. Rupprecht S, Frank K, Fitzek S, Witte OW, Hagemann G. Levetiracetam as a treatment option in non-convulsive status epilepticus. Epilepsy Res. 2007;73:238–244
  9. Patel NC, Landan IR, Levin J, Szaflarski J, Wilner AN. The use of levetiracetam in refractory status epilepticus. Seizure. 2006;15:137–141
  10. Rossetti AO, Bromfield EB. Determinants of successful use of oral levetiracetam in status epilepticus. Epilepsy Behav. 2006;86:51–54

PII: S0887-8994(07)00565-6

doi: 10.1016/j.pediatrneurol.2007.11.003

Pediatric Neurology
Volume 38, Issue 3 , Pages 177-180 , March 2008

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