Pediatric Neurology
Volume 38, Issue 3 , Pages 196-199 , March 2008

Childhood Thalidomide Neuropathy: A Clinical and Neurophysiologic Study

  • Tiziana Priolo, MD

      Affiliations

    • Children’s Neuropsychiatry Operative Unit, Department of Neurosciences, Ophthalmology, and Genetics, IRCCS G. Gaslini Institute, University of Genoa, Genoa, Italy
    • ,
  • Laura Doria Lamba, MD

      Affiliations

    • Children’s Neuropsychiatry Operative Unit, Department of Neurosciences, Ophthalmology, and Genetics, IRCCS G. Gaslini Institute, University of Genoa, Genoa, Italy
    • Corresponding Author InformationCommunications should be addressed to: Dr. Lamba; Pediatric Neuropsychiatry Unit, Department of Neurosciences, Ophthalmology, and Genetics; G. Gaslini Institute, University of Genoa; L.go Gaslini 5; 16148 Genova Quarto, Italy.
    • ,
  • Gaia Giribaldi, MD

      Affiliations

    • Children’s Neuropsychiatry Operative Unit, Department of Neurosciences, Ophthalmology, and Genetics, IRCCS G. Gaslini Institute, University of Genoa, Genoa, Italy
    • ,
  • Emanuela De Negri, MD

      Affiliations

    • Children’s Neuropsychiatry Operative Unit, Department of Neurosciences, Ophthalmology, and Genetics, IRCCS G. Gaslini Institute, University of Genoa, Genoa, Italy
    • ,
  • Paolo Grosso, PhD

      Affiliations

    • Children’s Neuropsychiatry Operative Unit, Department of Neurosciences, Ophthalmology, and Genetics, IRCCS G. Gaslini Institute, University of Genoa, Genoa, Italy
    • ,
  • Elisa De Grandis, MD

      Affiliations

    • Children’s Neuropsychiatry Operative Unit, Department of Neurosciences, Ophthalmology, and Genetics, IRCCS G. Gaslini Institute, University of Genoa, Genoa, Italy
    • ,
  • Edvige Veneselli, MD

      Affiliations

    • Children’s Neuropsychiatry Operative Unit, Department of Neurosciences, Ophthalmology, and Genetics, IRCCS G. Gaslini Institute, University of Genoa, Genoa, Italy
    • ,
  • Antonella Buoncompagni, MD

      Affiliations

    • Operative Unit of Pediatrics II, Department of Pediatrics, IRCCS G. Gaslini Institute, University of Genoa, Genoa, Italy
    • ,
  • Stefania Viola, MD

      Affiliations

    • Operative Unit of Pediatrics II, Department of Pediatrics, IRCCS G. Gaslini Institute, University of Genoa, Genoa, Italy
    • ,
  • Maria Giannina Alpigiani, MD

      Affiliations

    • Pediatric Clinic, Department of Pediatrics, University of Genoa, IRCCS G. Gaslini Institute, Genoa, Italy
    • ,
  • Paolo Gandullia, MD

      Affiliations

    • Operative Unit of Pediatrics III, Department of Pediatrics, IRCCS G. Gaslini Institute, University of Genoa, Genoa, Italy
    • ,
  • Maria G. Calevo, PhD

      Affiliations

    • Service of Epidemiology and Biostatistics, IRCCS G. Gaslini Institute, University of Genoa, Genoa, Italy.

Received 23 April 2007 ,Accepted 12 November 2007.

References 

  1. Lafitte E, Revuz J. Thalidomide: An old drug with new clinical applications. Expert Opin Drug Saf. 2004;3:47–56
  2. Strauss RS, Das KM. Thalidomide-induced sensory neuropathy. J Pediatr Gastroenterol Nutr. 2001;32:322–324
  3. Hess CW, Hunziker T, Kupfer A, Ludin HP. Thalidomide-induced peripheral neuropathy (A prospective clinical, neurophysiological and pharmacogenetic evaluation). J Neurol. 1986;233:83–89
  4. Bastuji-Garin S, Ochonisky S, Bouche P, et al. Incidence and risk factors for thalidomide neuropathy: A prospective study of 135 dermatologic patients. J Invest Dermatol. 2002;119:1020–1026
  5. Briani C, Zara G, Rondinone R, et al. Thalidomide neurotoxicity: Prospective study in patients with lupus erythematosus. Neurology. 2004;62:2288–2290
  6. Fleming FJ, Vytopil M, Chaitow J, Jones HR, Darras BT, Ryan MM. Thalidomide neuropathy in childhood. Neuromusc Disord. 2005;15:172–176
  7. Molloy FM, Floeter MK, Syed NA, et al. Thalidomide neuropathy in patients treated for metastatic prostate cancer. Muscle Nerve. 2001;24:1050–1057
  8. Chaudhry V, Cornblath DR, Corse A, Freimer M, Simmons-O’Brien E, Vogelsang G. Thalidomide-induced neuropathy. Neurology. 2002;59:1872–1875
  9. Cavalletti G, Beronio A, Reni L, et al. Thalidomide sensory neurotoxicity: A clinical and neurophysiologic study. Neurology. 2004;62:2291–2293
  10. El Moutawakil B, Rafai MA, Gam I, Tahiri JM, Rhimou A, Slassi I. Crohn’s disease presenting with recurrent acute polyradiculoneuropathy. Rev Neurol (Paris). 2007;163:244–246
  11. Pineda Marfa M. Neurological involvement in rheumatic disorders and vasculitis in childhood. Rev Neurol (Paris). 2002;35:290–296
  12. Kari J, Shah V, Dillon M. Behçet’s disease in UK children: Clinical features and treatment including thalidomide. Rheumatology 200;40:933-8.
  13. Facchini S, Candusso M, Martelossi S, Liubich M, Panfili E, Ventura A. Efficacy of long-term treatment with thalidomide in children and young adults with Crohn’s disease: Preliminary results. J Pediatr Gastroenterol Nutr. 2001;32:178–181
  14. Lehman TJA, Striegel KH, Onel KB. Thalidomide therapy for recalcitrant systemic onset juvenile rheumatoid arthritis. J Pediatr. 2002;140:125–127
  15. Fullerton PM, O’Sullivan DJ. Thalidomide neuropathy: A clinical, electrophysiological, and histological follow-up study. J Neurol Neurosurg Psychiatry. 1968;31:543–551
  16. Giannini F, Volpi N, Rossi S, Passero S, Figiani M, Cerase A. Thalidomide-induced neuropathy: A ganglionopathy?. Neurology. 2003;60:877–878
  17. Isoardo G, Bergui M, Durelli L, et al. Thalidomide neuropathy: Clinical, electrophysiological and neuroradiological features. Acta Neurol Scand. 2004;109:188–193

PII: S0887-8994(07)00566-8

doi: 10.1016/j.pediatrneurol.2007.11.004

Pediatric Neurology
Volume 38, Issue 3 , Pages 196-199 , March 2008

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