Pediatric Neurology
Volume 38, Issue 5 , Pages 340-344 , May 2008

Discontinuation of Medications After Successful Epilepsy Surgery in Children

  • Deepak K. Lachhwani, MD

      Affiliations

    • Epilepsy Center, Cleveland Clinic Foundation, Cleveland, Ohio
    • Corresponding Author InformationCommunications should be addressed to: Dr. Lachhwani; Section of Pediatric Epilepsy; Epilepsy Center; Neurological Institute; Cleveland Clinic Foundation; 9500 Euclid Ave, S-51; Cleveland, OH 44195.
    • ,
  • Tobias Loddenkemper, MD

      Affiliations

    • Epilepsy Center, Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Katherine D. Holland, MD

      Affiliations

    • Department of Neurology, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
    • ,
  • Prakash Kotagal, MD

      Affiliations

    • Epilepsy Center, Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Edward Mascha, PhD

      Affiliations

    • Department of Quantitative Health Sciences and Outcomes Research, Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • William Bingaman, MD

      Affiliations

    • Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, Ohio
    • ,
  • Elaine Wyllie, MD

      Affiliations

    • Epilepsy Center, Cleveland Clinic Foundation, Cleveland, Ohio

Received 17 October 2007 ,Accepted 28 January 2008.

References 

  1. Gilliam F, Wyllie E, Kashden J, et al. Epilepsy surgery outcome: comprehensive assessment in children. Neurology. 1997;48:1368–1374
  2. Schmidt D, Baumgartner C, Löscher W. Seizure recurrence after planned discontinuation of antiepileptic drugs in seizure-free patients after epilepsy surgery: a review of current clinical experience. Epilepsia. 2004;45:179–186
  3. Al Kaylani M, Konrad P, Lazenby B, Blumenkopf B, Abou-Khalil B. Seizure freedom off antiepileptic drugs after temporal lobe epilepsy surgery. Seizure. 2007;16:95–98
  4. Camfield P, Camfield C. The frequency of intractable seizures after stopping AEDs in seizure-free children with epilepsy. Neurology. 2005;64:973–975
  5. Shinnar S, Berg AT, Moshé SL, et al. Discontinuing antiepileptic drugs in children with epilepsy: a prospective study. Ann Neurol. 1994;35:534–545
  6. Andermann F, Bourgeois BF, Leppik IE, Sherwin AL. Postoperative pharmacotherapy and discontinuation of antiepileptic drugs. In:  Engel J editors. Surgical treatment of the epilepsies. New York: Raven Press; 1993;p. 679–684
  7. Schiller Y, Cascino GD, So EL, Marsh WR. Discontinuation of antiepileptic drugs after successful epilepsy surgery. Neurology. 2000;54:346–349
  8. Verrotti A, Morresi S, Basciani F, Cutarella R, Morgese G, Chiarelli F. Discontinuation of anticonvulsant therapy in children with partial epilepsy. Neurology. 2000;55:1393–1395
  9. Berg AT, Vickrey BG, Langfitt JT, et al. Multicenter Study of Epilepsy Surgery (Reduction of AEDs in postsurgical patients who attain remission). Epilepsia. 2006;47:64–71
  10. Kuzniecky R, Rubin ZK, Faught E, Morawetz R. Antiepileptic drug treatment after temporal lobe epilepsy surgery: a randomized study comparing carbamazepine and polytherapy. Epilepsia. 1992;33:908–912
  11. Hoppe C, Poepel A, Sassen R, Elger CE. Discontinuation of anticonvulsant medication after epilepsy surgery in children. Epilepsia. 2006;47:580–583
  12. Telfeian AE, Philips MF, Crino PB, Judy KD. Postoperative epilepsy in patients undergoing craniotomy for glioblastoma multiforme. J Exp Clin Cancer Res. 2001;20:5–10
  13. Godoy J, Lüders H, Dinner DS, Morris HH, Wyllie E, Murphy D. Significance of sharp waves in routine EEGs after epilepsy surgery. Epilepsia. 1992;33:285–288
  14. So N, Olivier A, Andermann F, Gloor P, Quesney LF. Results of surgical treatment in patients with bitemporal epileptiform abnormalities. Ann Neurol. 1989;25:432–439
  15. Ranganathan LN, Ramaratnam S. Rapid versus slow withdrawal of antiepileptic drugs. Cochrane Database Syst Rev. 2006;(2):CD005003
  16. Téllez-Zenteno JF, Dhar R, Hernandez-Ronquillo L, Wiebe S. Long-term outcomes in epilepsy surgery: antiepileptic drugs, mortality, cognitive and psychosocial aspects. Brain. 2007;130:334–345
  17. Lachhwani D, Wyllie E, Loddenkemper T, Holland K, Kotagal P, Bingaman W. Discontinuation of antiepileptic medications following epilepsy surgery in childhood and adolescence. [Abstract] Neurology. 2003;60(Suppl 1):A259
  18. Maher J, McLachlan RS. Antiepileptic drug treatment following temporal lobectomy. Neurology. 1998;51:305–307
  19. Mani J, Gupta A, Mascha E, et al. Postoperative seizures after extratemporal resections and hemispherectomy in pediatric epilepsy. Neurology. 2006;66:1038–1043

PII: S0887-8994(08)00058-1

doi: 10.1016/j.pediatrneurol.2008.01.010

Pediatric Neurology
Volume 38, Issue 5 , Pages 340-344 , May 2008

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