Pediatric Neurology
Volume 40, Issue 3 , Pages 197-204 , March 2009

A New Look at Outcomes of Infants With Congenital Heart Disease

  • Annette Majnemer, PhD, OT

      Affiliations

    • School of Physical and Occupational Therapy, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada
    • Department of Neurology & Neurosurgery, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada
    • Department of Pediatrics, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada
    • Corresponding Author InformationCommunications should be addressed to: Dr. Majnemer; Division of Pediatric Neurology; Montreal Children's Hospital; 2300 Tupper, Room A-509; Montreal, Quebec, H3H 1P3; Canada.
  • ,
  • Catherine Limperopoulos, PhD, OT

      Affiliations

    • School of Physical and Occupational Therapy, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada
    • Department of Neurology & Neurosurgery, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada
    • Department of Pediatrics, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada
  • ,
  • Michael I. Shevell, MDCM

      Affiliations

    • Department of Neurology & Neurosurgery, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada
    • Department of Pediatrics, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada
  • ,
  • Charles Rohlicek, MDCM

      Affiliations

    • Department of Pediatrics, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada
  • ,
  • Bernard Rosenblatt, MDCM

      Affiliations

    • Department of Neurology & Neurosurgery, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada
    • Department of Pediatrics, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada
  • ,
  • Christo Tchervenkov, MDCM

      Affiliations

    • Department of Cardiovascular Surgery, McGill University, Montreal Children's Hospital–McGill University Health Centre, Montreal, Quebec, Canada

Received 14 May 2008 ,Accepted 7 August 2008.

References 

  1. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002;39:1890–1900
  2. Rudolph AM. Congenital diseases of the heart: clinical-physiological considerations. 2nd ed.. Armonk, NY: Futura Publishing; 2001;
  3. Brown MD, Wernovsky G, Mussatto KA, Berger S. Long-term and developmental outcomes of children with complex congenital heart disease. Clin Perinatol. 2005;32:1043–1057xi
  4. Majnemer A, Limperopoulos C. Developmental progress of children with congenital heart defects requiring open heart surgery. Semin Pediatr Neurol. 1999;6:12–19
  5. du Plessis AJ. Mechanisms of brain injury during infant cardiac surgery. Semin Pediatr Neurol. 1999;6:32–47
  6. Limperopoulos C, du Plessis AJ. Neurological manifestations of congenital heart disease and cardiac surgery in children. Chapter 4. In:  Aminoff MJ editors. Neurology and general medicine. 4th ed.. New York: Churchill Livingstone, Elsevier; 2008;p. 61–74
  7. Wernovsky G. Current insights regarding neurological and developmental abnormalities in children and young adults with complex congenital cardiac disease. Cardiol Young. 2006;16(Suppl 1):92–104
  8. Dittrich H, Bührer C, Grimmer I, Dittrich S, Abdul-Khaliq H, Lange PE. Neurodevelopment at 1 year of age in infants with congenital heart disease. Heart. 2003;89:436–441
  9. Bellinger DC, Wernovsky G, Rappaport LA, et al. Cognitive development of children following early repair of transposition of the great arteries using deep hypothermic circulatory arrest. Pediatrics. 1991;87:701–707
  10. Miller G, Eggli KD, Contant C, Baylen BG, Myers JL. Postoperative neurologic complications after open heart surgery on young infants. Arch Pediatr Adolesc Med. 1995;149:764–768
  11. Wray J. Intellectual development of infants, children and adolescents with congenital heart disease. Dev Sci. 2006;9:368–378
  12. Majnemer A, Mazer B. New directions in the outcome evaluation of children with cerebral palsy. Semin Pediatr Neurol. 2004;11:11–17
  13. Majnemer A, Limperopoulos C. Importance of outcome determination in pediatric rehabilitation. Dev Med Child Neurol. 2002;44:773–777
  14. Folio MR, Fewell RR. Peabody developmental motor scales and activity cards. Allen, Texas: DLM Teaching Resources. 1983;
  15. Sparrow S, Balla DA, Cicchetti DV. Vineland adaptive behavior scales, interview edition, survey form manual: a revision of the Vineland social maturity scale by EA Doll. Circle Pines, MN: American Guidance Service; 1984;
  16. UDSMR Uniform Data System for Medical Rehabilitation. WeeFIM System–Clinical Guide. Version 5.01. Buffalo, NY: University of Buffalo; 1998;
  17. Griffiths R. The abilities of young children: a study in mental measurement. London: University of London Press; 1970;
  18. Psychological Corporation. WPPSI-R: Wechsler preschool and primary scale of intelligence–revised. San Antonio, TX: Harcourt Brace Jovanovich; 1989;
  19. Dunn LM. Peabody Picture Vocabulary Test. 3rd ed.. Circle Pines, MN: American Guidance Service; 1997;
  20. Achenbach TM. Manual for the CBCL/4-18 and 1991 profile. Burlington, VT: University of Vermont, Department of Psychiatry; 1991;
  21. Landgraf JM, Abetz L, Ware JE. The CHQ user's manual. 1st ed.. Boston, MA: The Health Institute, New England Medical Center; 1996;
  22. Abidin RR. Parenting Stress Index short form: test manual. Charlottesville, VA: Pediatric Psychology Press; 1990;
  23. Limperopoulos C, Majnemer A, Shevell MI, Rosenblatt B, Rohlicek C, Tchervenkov C. Neurologic status of newborns with congenital heart defects prior to open heart surgery. Pediatrics. 1999;103:402–408
  24. Limperopoulos C, Majnemer A, Shevell MI, Rosenblatt B, Rohlicek C, Tchervenkov C. Neurodevelopmental status of newborns and infants with congenital heart defects before and after open heart surgery. J Pediatr. 2000;137:638–645
  25. Limperopoulos C, Majnemer A, Rosenblatt B, Shevell M, Rohlicek C, Tchervenkov C. Agreement between the neonatal neurological examination and a standardized assessment of neurobehavioural performance in a group of high-risk newborns. Pediatr Rehabil. 1997;1:9–14
  26. Limperopoulos C, Majnemer A, Shevell M, et al. Predictors of developmental disabilities after open heart surgery in young children with congenital heart defects. J Pediatr. 2002;141:51–58
  27. Limperopoulos C, Majnemer A, Shevell M, et al. Functional limitations in young children with congenital heart defects following cardiac surgery. Pediatrics. 2001;108:1325–1331
  28. Si Y, Gotman J, Pasupathy A, Flanagan D, Rosenblatt B, Gottesman R. An expert system for EEG monitoring in the pediatric intensive care unit. Electroencephalogr Clin Neurophysiol. 1998;106:488–500
  29. Limperopoulos C, Majnemer A, Rosenblatt B, et al. Association between electroencephalographic findings and neurologic status in infants with congenital heart defects. J Child Neurol. 2001;16:471–476
  30. Limperopoulos C, Majnemer A, Rosenblatt B, Shevell M, Rohlicek C, Tchervenkov C. Multimodal evoked potential findings in infants with congenital heart defects. J Child Neurol. 1999;14:702–707
  31. Majnemer A, Limperopoulos C, Shevell M, Rosenblatt B, Rohlicek C, Tchervenkov C. Long-term neuromotor outcome at school entry of infants with congenital heart defects requiring open-heart surgery. J Pediatr. 2006;148:72–77
  32. Majnemer A, Limperopoulos C, Shevell M, Rohlicek C, Rosenblatt B, Tchervenkov C. Developmental and functional outcomes at school entry in children with congenital heart defects. J Pediatr. 2008;153:55–60
  33. Majnemer A, Limperopoulos C, Shevell M, Rohlicek C, Rosenblatt B, Tchervenkov C. Health and well-being of children with congenital cardiac malformations, and their families, following open-heart surgery. Cardiol Young. 2006;16:157–164
  34. Majnemer A, Mazer B, Lecker E, et al. Patterns of use of educational and rehabilitation services at school age for children with congenitally malformed hearts. Cardiol Young. 2008;18:288–296
  35. Donofrio MT, Bremer YA, Schieken RM, et al. Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect. Pediatr Cardiol. 2003;24:436–443
  36. Mahle WT, Tavani F, Zimmerman RA, et al. An MRI study of neurological injury before and after congenital heart surgery. Circulation. 2002;106:I109–I114
  37. Miller SP, McQuillen PS, Hamrick S, et al. Abnormal brain development in newborns with congenital heart disease. N Engl J Med. 2007;357:1928–1938
  38. Ferriero DM. Neonatal brain injury. N Engl J Med. 2004;351:1985–1995
  39. Majnemer A. Benefits of early intervention in children with developmental disabilities. Semin Pediatr Neurol. 1998;5:62–69
  40. Spittle AJ, Orton J, Doyle LW, Boyd R. Early developmental intervention programs post hospital discharge to prevent motor and cognitive impairments in preterm infants (review). Cochrane Database Syst Rev. 2007;(2):CD005495

PII: S0887-8994(08)00471-2

doi: 10.1016/j.pediatrneurol.2008.09.014

Pediatric Neurology
Volume 40, Issue 3 , Pages 197-204 , March 2009