Pediatric Neurology
Volume 40, Issue 2 , Pages 126-127 , February 2009

The Effect of Constipation on Valproic Acid Dosage in a 17-Year-Old

  • Jennifer E. Madan Cohen, MD

      Affiliations

    • Saul R. Korey Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York
    • Department of Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York
    • Epilepsy Management Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York
    • Corresponding Author InformationCommunications should be addressed to: Dr. Madan Cohen; 282 Washington Street; Department of Neurology, 2A; Connecticut Children's Medical Center; Hartford, CT 06106.
    • ,
  • Solomon L. Moshe, MD

      Affiliations

    • Saul R. Korey Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York
    • Department of Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York
    • Epilepsy Management Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York
    • Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York

Received 30 June 2008 ,Accepted 13 October 2008.

References 

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  4. Bourin M, Guenzet J, Thomare P, Kergueris MF, Ortega A, Larousse C. Effects of administration route on valproate pharmacokinetics in the rabbit. Fundam Clin Pharmacol. 1991;5:331–339
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  11. AHFS drug information. Bethesda, MD: American Society of Health-System Pharmacists; 2002;2170-7
  12. Royer-Morrot MJ, Zhiri A, Jacob F, Necciari J, Lascombes F, Royer RJ. Influence of food intake on the pharmacokinetics of a sustained release formulation of sodium valproate. Biopharm Drug Dispos. 1993;14:511–518
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  14. Hamilton RA, Garnett WR, Kline BJ, Pellock JM. Effects of food on valproic acid absorption. Am J Hosp Pharm. 1981;38:1490–1493
  15. Staiano A, Del Giudice E. Colonic transit and anorectal manometry in children with severe brain damage. Pediatrics. 1994;94:169–173

PII: S0887-8994(08)00536-5

doi: 10.1016/j.pediatrneurol.2008.10.008

Pediatric Neurology
Volume 40, Issue 2 , Pages 126-127 , February 2009

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