Pediatric Neurology
Volume 41, Issue 1 , Pages 65-67 , July 2009

Autism and Hypoplastic Corpus Callosum in a Case of Monocentric Marker Chromosome 15

  • Jadranka D. Jovanović-Privrodski, MD, PhD

      Affiliations

    • Institute for Children and Youth Health Care Vojvodina, Center for Medical Genetics, Medical Faculty, 21000 Novi Sad, Serbia
    • Corresponding Author InformationCommunications should be addressed to: Dr. Jovanović-Privrodski; Bulevar Cara Lazara 83; 21000 Novi Sad, Serbia.
    • ,
  • Ivana I. Kavečan, MD, BSc

      Affiliations

    • Institute for Children and Youth Health Care Vojvodina, Center for Medical Genetics, Medical Faculty, 21000 Novi Sad, Serbia
    • ,
  • Milan R. Obrenović, MD

      Affiliations

    • Institute for Children and Youth Health Care Vojvodina, Center for Medical Genetics, Medical Faculty, 21000 Novi Sad, Serbia
    • ,
  • Lucia A. Buonadonna, BSc

      Affiliations

    • Hospital-Bari, Department of Genetics, Bari, Italy
    • ,
  • Nenad M. Bukvić, PhD

      Affiliations

    • University Hospital Foggia, Department of Laboratory, Diagnostics, Section of Cytogenetics and Molecular Biology, Foggia, Italy

Received 22 October 2008 ,Accepted 4 February 2009.

References 

  1. Liehr T, Weise A. Frequency of small supernumerary marker chromosomes in prenatal, newborn, developmentally retarded and infertility diagnostics. Int J Mol Med. 2007;19:719–731
  2. Crolla JA, Youings SA, Ennis S, Jacobs PA. Supernumerary marker chromosomes in man: parental origin, mosaicism and maternal age revisited. Eur J Hum Genet. 2005;13:154–160
  3. Eggermann K, Mau UA, Bujdosó G, et al. Supernumerary marker chromosomes derived from chromosome 15: analysis of 32 new cases. Clin Genet. 2002;62:89–93
  4. In:  Shaffer LG,  Tommerup N editor. ISCN 2005: an international system for human cytogenetic nomenclature (2005). Basel: S. Karger; 2005;
  5. Schroer RJ, Phelan MC, Michaelis RC, et al. Autism and maternally derived aberrations of chromosome 15q. Am J Med Genet. 1998;76:327–336
  6. Woo HY, Cho HJ, Kong SY, et al. Marker chromosomes in Korean patients: incidence, identification and diagnostic approach [Erratum in: J Korean Med Sci 2004;54:1011-1012]. J Korean Med Sci. 2003;18:773–778
  7. Casaubon LK, Melanson M, Lopes-Cendes I, et al. The gene responsible for a severe form of peripheral neuropathy and agenesis of the corpus callosum maps to chromosome 15q. Am J Hum Genet. 1996;58:28–34
  8. Kobayashi E, Facchin D, Steiner CE, et al. Mesial temporal lobe abnormalities in a family with 15q26qter trisomy. Arch Neurol. 2002;59:1476–1479
  9. Ungerleider S. Update and review: supernumerary marker chromosomes. J Genet Couns. 2000;4:347–355
  10. Freitag CM. The genetics of autistic disorders and its clinical relevance: a review of the literature. Mol Psychiatry. 2007;12:2–22
  11. Weiss LA, Shen Y, Korn JM, et al. Autism Consortium. Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med. 2008;358:667–675
  12. Kwasnicka-Crawford DA, Roberts W, Scherer SW. Characterization of an autism-associated segmental maternal heterodisomy of the chromosome 15q11-13 region. J Autism Dev Disord. 2007;37:694–702
  13. Barkovich AJ. Anomalies of the corpus callosum and cortical malformations. In:  Barth PG editors. Disorders of neuronal migration. London: Mac Keith Press; 2003;p. 83–103
  14. Sztriha L. Spectrum of corpus callosum agenesis. Pediatr Neurol. 2005;32:94–101
  15. Mohandas TK, Park JP, Spellman RA, et al. Paternally derived de novo interstitial duplication of proximal 15q in a patient with developmental delay. Am J Med Genet. 1999;82:294–300

PII: S0887-8994(09)00078-2

doi: 10.1016/j.pediatrneurol.2009.02.004

Pediatric Neurology
Volume 41, Issue 1 , Pages 65-67 , July 2009

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