Pediatric Neurology
Volume 41, Issue 6 , Pages 451-452, December 2009

Isolated Ptosis as Acute Ophthalmoplegia Without Ataxia, Positive for Anti-GQ1b Immunoglobulin G

Department of Pediatrics, Government Medical College, Sector 32, Chandigarh, India. V.R.P. is currently affiliated with HNB Teaching Hospital, Government Medical College, Srinagar, Uttarakhand, India

Received 2 March 2009; accepted 14 July 2009.

Anti-GQ1b IgG antibody syndrome comprises a wide range of diseases presenting with ophthalmoplegia and ataxia. Anti-GQ1b antibodies have been strongly associated in the literature with Miller Fisher Syndrome, with acute ophthalmoplegia associated with Guillain-Barré syndrome, and with isolated ophthalmoplegia. Acute ophthalmoplegia presents as various combinations of external and internal ophthalmoplegia. Reported here is a novel case of isolated ptosis as a manifestation of ophthalmoplegia. The present finding of bilateral ptosis and areflexia with anti-GQ1b IgG antibody positivity helps confirm the existence of the syndrome. Further research is needed on diagnosis and treatment.

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PII: S0887-8994(09)00358-0

doi:10.1016/j.pediatrneurol.2009.07.008

Pediatric Neurology
Volume 41, Issue 6 , Pages 451-452, December 2009