Pediatric Neurology
Volume 42, Issue 2 , Pages 101-106 , February 2010

Diffusion Features of White Matter in Tuberous Sclerosis With Tractography

  • Michelle L. Krishnan, MBBS

      Affiliations

    • Computational Radiology Laboratory, Department of Radiology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts
    • ,
  • Olivier Commowick, PhD

      Affiliations

    • Computational Radiology Laboratory, Department of Radiology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts
    • ,
  • Shafali S. Jeste, MD

      Affiliations

    • Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts
    • ,
  • Neil Weisenfeld, MS

      Affiliations

    • Computational Radiology Laboratory, Department of Radiology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts
    • ,
  • Arne Hans, PhD

      Affiliations

    • Computational Radiology Laboratory, Department of Radiology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts
    • ,
  • Matthew C. Gregas, PhD

      Affiliations

    • Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts
    • ,
  • Mustafa Sahin, MD, PhD

      Affiliations

    • Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationCommunications should be addressed to: Dr. Sahin; Department of Neurology; Children's Hospital; CLSB 13074; Boston, MA 02115.
    • ,
  • Simon K. Warfield, PhD

      Affiliations

    • Computational Radiology Laboratory, Department of Radiology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts

Received 1 June 2009 ,Accepted 6 August 2009.

References 

  1. Crino PB, Nathanson KL, Henske EP. The tuberous sclerosis complex. N Engl J Med. 2006;355:1345–1356
  2. Osborne JP, Fryer A, Webb D. Epidemiology of tuberous sclerosis. Ann N Y Acad Sci. 1991;615:125–127
  3. Curatolo P, Verdecchia M, Bombardieri R. Tuberous sclerosis complex: a review of neurological aspects. Eur J Paediatr Neurol. 2002;6:15–23
  4. Jeste SS, Sahin M, Bolton P, Ploubidis GB, Humphrey A. Characterization of autism in young children with tuberous sclerosis complex. J Child Neurol. 2008;23:520–525
  5. Jansen FE, Vincken KL, Algra A, et al. Cognitive impairment in tuberous sclerosis complex is a multifactorial condition. Neurology. 2008;70:916–923
  6. Walz NC, Byars AW, Egelhoff JC, Franz DN. Supratentorial tuber location and autism in tuberous sclerosis complex. J Child Neurol. 2002;17:830–832
  7. Wong V. Study of the relationship between tuberous sclerosis complex and autistic disorder. J Child Neurol. 2006;21:199–204
  8. Meikle L, Talos DM, Onda H, et al. A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J Neurosci. 2007;27:5546–5558
  9. Sahin M. Neuronal connectivity in TSC. Presented at Tuberous Sclerosis Complex: from Genes to New Therapeutics. International TSC Research Symposium organized by the Tuberous Sclerosis Alliance, September 23-25, 2007, Annapolis, MD.
  10. Chandra PS, Salamon N, Huang J, et al. FDG-PET/MRI coregistration and diffusion-tensor imaging distinguish epileptogenic tubers and cortex in patients with tuberous sclerosis complex: a preliminary report. Epilepsia. 2006;47:1543–1549
  11. Luat AF, Makki M, Chugani HT. Neuroimaging in tuberous sclerosis complex. Curr Opin Neurol. 2007;20:142–150
  12. Makki MI, Chugani DC, Janisse J, Chugani HT. Characteristics of abnormal diffusivity in normal-appearing white matter investigated with diffusion tensor MR imaging in tuberous sclerosis complex. AJNR Am J Neuroradiol. 2007;28:1662–1667
  13. Roach ES, Gomez MR, Northrup H. Tuberous Sclerosis Complex Consensus Conference: revised clinical diagnostic criteria. J Child Neurol. 1998;13:624–628
  14. Lee JE, Bigler ED, Alexander AL, et al. Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism. Neurosci Lett. 2007;424:127–132
  15. Conturo TE, Lori NF, Cull TS, et al. Tracking neuronal fiber pathways in the living human brain. Proc Natl Acad Sci U S A. 1999;96:10422–10427
  16. Mori S, Kaufmann WE, Davatzikos C, et al. Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. Magn Reson Med. 2002;47:215–223
  17. Wakana S, Caprihan A, Panzenboeck MM, et al. Reproducibility of quantitative tractography methods applied to cerebral white matter. Neuroimage. 2007;36:630–644
  18. Behrens TE, Johansen-Berg H, Woolrich MW, et al. Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci. 2003;6:750–757
  19. Yamamoto T, Yamada K, Nishimura T, Kinoshita S. Tractography to depict three layers of visual field trajectories to the calcarine gyri. Am J Ophthalmol. 2005;140:781–785
  20. Friman O, Farnebäck G, Westin CF. A.Bayesian approach for stochastic white matter tractography. IEEE Trans Med Imaging. 2006;25:965–978
  21. Ngo T. A stochastic tractography system and applications [master's thesis]. Cambridge, MA: Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology; 2007;
  22. Provenzale JM, Liang L, DeLong D, White LE. Diffusion tensor imaging assessment of brain white matter maturation during the first postnatal year. AJR Am J Roentgenol. 2007;189:476–486
  23. Beaulieu C, Allen PS. Determinants of anisotropic water diffusion in nerves. Magn Reson Med. 1994;31:394–400
  24. Gulani V, Webb AG, Duncan ID, Lauterbur PC. Apparent diffusion tensor measurements in myelin-deficient rat spinal cords. Magn Reson Med. 2001;45:191–195
  25. Drobyshevsky A, Song SK, Gamkrelidze G, et al. Developmental changes in diffusion anisotropy coincide with immature oligodendrocyte progression and maturation of compound action potential. J Neurosci. 2005;25:5988–5997
  26. Budde MD, Xie M, Cross AH, Song SK. Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci. 2009;29:2805–2813
  27. Neil JJ, Shiran SI, McKinstry RC, et al. Normal brain in human newborns: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MR imaging. Radiology. 1998;209:57–66
  28. Larvaron P, Boespflug-Tanguy O, Renou JP, Bonny JM. In vivo analysis of the post-natal development of normal mouse brain by DTI. NMR Biomed. 2007;20:413–421
  29. Choi YJ, Di Nardo A, Kramvis I, et al. Tuberous sclerosis complex proteins control axon formation. Genes Dev. 2008;22:2485–2495
  30. Gernsbacher MA, Kaschak MP. Neuroimaging studies of language production and comprehension. Annu Rev Psychol. 2003;54:91–114
  31. Pelphrey KA, Viola RJ, McCarthy G. When strangers pass: processing of mutual and averted social gaze in the superior temporal sulcus. Psychol Sci. 2004;15:598–603
  32. Peresson M, Lopez L, Narici L, Curatolo P. Magnetic source imaging and reactivity to rhythmical stimulation in tuberous sclerosis. Brain Dev. 1998;20:512–518
  33. Major P, Rakowski S, Simon MV, et al. Are cortical tubers epileptogenic? Evidence from electrocorticography. Epilepsia. 2009;50:147–154

PII: S0887-8994(09)00389-0

doi: 10.1016/j.pediatrneurol.2009.08.001

Pediatric Neurology
Volume 42, Issue 2 , Pages 101-106 , February 2010

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