Pediatric Neurology
Volume 42, Issue 3 , Pages 181-186 , March 2010

Association Between Prenatal Stress and Infantile Spasms: A Case-Control Study in China

  • Ning-Xiu Shang, MD

      Affiliations

    • Department of Neurology, Capital Institute of Pediatrics, Beijing, China
    • Both authors contributed equally to this work.
    • ,
  • Li-Ping Zou, MD, PhD

      Affiliations

    • Department of Pediatrics, Chinese PLA General Hospital, Beijing, China
    • Corresponding Author InformationCommunications should be addressed to: Dr. Zou; Department of Pediatrics; Chinese PLA General Hospital; 28 Fuxing Road; Beijing 100853, China.
    • Both authors contributed equally to this work.
    • ,
  • Jian-Bo Zhao, MD

      Affiliations

    • Department of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing, China
    • ,
  • Feng Zhang, MD

      Affiliations

    • Child Care Center, Beijing Children's Hospital, Capital Medical University, Beijing, China
    • ,
  • Hua Li, MD

      Affiliations

    • Department of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing, China

Received 1 April 2009 ,Accepted 9 September 2009.

Reference 

  1. Lux AL, Osborne JP. A proposal for case definitions and outcome measures in studies of infantile spasms and West syndrome: consensus statement of the West Delphi group. Epilepsia. 2004;45:1416–1428
  2. Frost JD, Hrachovy RA. Pathogenesis of infantile spasms: a model based on developmental desynchronization. J Clin Neurophysiol. 2005;22:25–36
  3. Velíšek L, Jehle K, Asche S, Velísková J. Model of infantile spasms induced by N-methyl-D-aspartic acid in prenatally impaired brain. Ann Neurol. 2007;61:109–119
  4. Brunson KL, Eghbal-Ahmadi M, Baram TZ. How do the many etiologies of West syndrome lead to excitability and seizures? The corticotropin releasing hormone excess hypothesis. Brain Dev. 2001;23:533–538
  5. Engel J. International League Against Epilepsy (ILAE). A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia. 2001;42:796–803
  6. Gao Y, Yang Y-F, Hong Q, Han T-Z, Yao K-N. Pregnant Woman Life Event Scale. [In Chinese] In: Behavioral Medicine Scale Manual. Beijing: Chinese Medical Electronic Audio-Visual Publishing Houses; 2005;p. 265–266
  7. Baram TZ, Mitchell WG, Snead OC, Horton EJ, Saito M. Brain-adrenal axis hormones are altered in the CSF of infants with massive infantile spasms. Neurology. 1992;42:1171–1175
  8. Baram TZ, Mitchell WG, Hanson RA, Snead OC, Horton EJ. Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms. Pediatr Neurol. 1995;13:108–110
  9. Murmu MS, Salomon S, Biala Y, Weinstock M, Braun K, Bock J. Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy. Eur J Neurosci. 2006;24:1477–1487
  10. Barros VG, Duhalde-Vega M, Caltana L, Brusco A, Antonelli MC. Astrocyte-neuron vulnerability to prenatal stress in the adult rat brain. J Neurosci Res. 2006;83:787–800
  11. Salm AK, Pavelko M, Krouse EM, Webster W, Kraszpulski M, Birkle DL. Lateral amygdaloid nucleus expansion in adult rats is associated with exposure to prenatal stress. Brain Res Dev Brain Res. 2004;148:159–167
  12. Lemaire V, Koehl M, Le Moal M, Abrous DN. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc Natl Acad Sci U S A. 2000;97:11032–11037
  13. Coe CL, Kramer M, Czéh B, et al. Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys. Biol Psychiatry. 2003;54:1025–1034
  14. Barros VG, Berger MA, Martijena ID, et al. Early adoption modifies the effects of prenatal stress on dopamine and glutamate receptors in adult rat brain. J Neurosci Res. 2004;76:488–496
  15. Brunson KL, Khan N, Eghbal-Ahmadi M, Baram TZ. Corticotropin (ACTH) acts directly on amygdala neurons to down-regulate corticotropin-releasing hormone gene expression. Ann Neurol. 2001;49:304–312

PII: S0887-8994(09)00435-4

doi: 10.1016/j.pediatrneurol.2009.09.003

Pediatric Neurology
Volume 42, Issue 3 , Pages 181-186 , March 2010

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